ENSG00000159082

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382491 ENSG00000159082 HEK293_OSMI2_2hA HEK293_TMG_2hB SYNJ1 protein_coding protein_coding 4.405655 2.647425 4.600856 0.3586458 0.05492532 0.7950056 0.2703193 0.05225318 0.2109167 0.05225318 0.2109167 1.827283 0.0514125 0.0262000 0.0451 0.0189000 9.625002e-01 1.268178e-12 FALSE TRUE
ENST00000438952 ENSG00000159082 HEK293_OSMI2_2hA HEK293_TMG_2hB SYNJ1 protein_coding protein_coding 4.405655 2.647425 4.600856 0.3586458 0.05492532 0.7950056 0.7694035 1.30145199 0.0000000 0.25912808 0.0000000 -7.035021 0.2547833 0.5011333 0.0000 -0.5011333 1.268178e-12 1.268178e-12 FALSE TRUE
ENST00000630077 ENSG00000159082 HEK293_OSMI2_2hA HEK293_TMG_2hB SYNJ1 protein_coding protein_coding 4.405655 2.647425 4.600856 0.3586458 0.05492532 0.7950056 3.0263047 1.19334138 3.8919807 0.35165022 0.1056042 1.697161 0.6225875 0.4402667 0.8460 0.4057333 2.320566e-03 1.268178e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159082 E001 0.0000000       21 32628759 32628762 4 -      
ENSG00000159082 E002 271.9151866 0.0148619665 9.676019e-09 1.196614e-07 21 32628763 32631378 2616 - 2.261 2.608 1.157
ENSG00000159082 E003 32.4189429 0.0006347596 9.835030e-01 9.937436e-01 21 32631379 32631537 159 - 1.456 1.534 0.265
ENSG00000159082 E004 43.4344471 0.0005173016 5.758344e-01 7.013591e-01 21 32631538 32631777 240 - 1.569 1.676 0.366
ENSG00000159082 E005 16.1076489 0.0012365804 8.410859e-01 9.008689e-01 21 32631778 32631801 24 - 1.176 1.231 0.195
ENSG00000159082 E006 0.0000000       21 32634861 32634881 21 -      
ENSG00000159082 E007 0.1515154 0.0430276963 1.000000e+00   21 32634882 32634884 3 - 0.076 0.000 -9.688
ENSG00000159082 E008 30.4934507 0.0007011397 4.332771e-01 5.756861e-01 21 32638908 32639125 218 - 1.451 1.473 0.078
ENSG00000159082 E009 16.2902757 0.0011478357 2.070277e-01 3.349770e-01 21 32639671 32639779 109 - 1.213 1.171 -0.151
ENSG00000159082 E010 12.1656677 0.0016318163 3.294411e-01 4.729515e-01 21 32641896 32641966 71 - 1.090 1.061 -0.108
ENSG00000159082 E011 0.9609246 0.0123364980 8.324624e-01 8.950178e-01 21 32642095 32642133 39 - 0.247 0.323 0.527
ENSG00000159082 E012 0.2944980 0.3952510445 6.861239e-01   21 32643410 32643457 48 - 0.141 0.000 -10.517
ENSG00000159082 E013 0.1451727 0.0433592581 1.000000e+00   21 32644968 32645006 39 - 0.076 0.000 -9.687
ENSG00000159082 E014 13.9985679 0.0014523877 9.694157e-01 9.848766e-01 21 32645646 32645789 144 - 1.110 1.187 0.274
ENSG00000159082 E015 20.3126832 0.0009774318 4.532410e-01 5.939964e-01 21 32646393 32646602 210 - 1.284 1.296 0.045
ENSG00000159082 E016 21.9822305 0.0347681381 7.606124e-01 8.446505e-01 21 32650184 32650346 163 - 1.301 1.360 0.203
ENSG00000159082 E017 15.5559808 0.0926606977 6.436806e-01 7.561658e-01 21 32653288 32653366 79 - 1.172 1.185 0.047
ENSG00000159082 E018 0.6685028 0.0169770598 3.904836e-01 5.344503e-01 21 32653367 32654101 735 - 0.141 0.323 1.527
ENSG00000159082 E019 9.7598629 0.0757530732 5.077239e-01 6.431660e-01 21 32656687 32656690 4 - 1.002 0.951 -0.189
ENSG00000159082 E020 29.3680738 0.0038118209 4.157707e-01 5.591274e-01 21 32656691 32656902 212 - 1.433 1.450 0.058
ENSG00000159082 E021 21.0631845 0.0010248152 3.086720e-01 4.509434e-01 21 32657003 32657120 118 - 1.305 1.296 -0.029
ENSG00000159082 E022 26.4013755 0.0056220857 4.214190e-02 9.498359e-02 21 32657716 32657872 157 - 1.423 1.332 -0.316
ENSG00000159082 E023 0.0000000       21 32658471 32658561 91 -      
ENSG00000159082 E024 25.6311562 0.0008920274 2.960189e-02 7.117483e-02 21 32664913 32665071 159 - 1.410 1.320 -0.314
ENSG00000159082 E025 13.6715395 0.0080636219 9.529246e-01 9.745297e-01 21 32665943 32665985 43 - 1.104 1.172 0.244
ENSG00000159082 E026 23.1229113 0.0106549075 1.327770e-01 2.379705e-01 21 32665986 32666135 150 - 1.359 1.298 -0.211
ENSG00000159082 E027 20.1347066 0.0010084428 8.747150e-03 2.565344e-02 21 32666433 32666573 141 - 1.325 1.171 -0.543
ENSG00000159082 E028 17.9785750 0.0052030440 8.198349e-02 1.626559e-01 21 32670288 32670372 85 - 1.262 1.171 -0.319
ENSG00000159082 E029 26.2667374 0.0020001447 1.268457e-01 2.297550e-01 21 32673340 32673531 192 - 1.404 1.364 -0.138
ENSG00000159082 E030 0.7322062 0.2710129836 2.207102e-01 3.512654e-01 21 32676332 32676355 24 - 0.291 0.000 -11.890
ENSG00000159082 E031 25.1042560 0.0008910879 4.131358e-01 5.566627e-01 21 32678645 32678801 157 - 1.370 1.384 0.050
ENSG00000159082 E032 10.3860510 0.0276227756 9.940718e-01 1.000000e+00 21 32678802 32678810 9 - 0.992 1.064 0.265
ENSG00000159082 E033 21.3356331 0.0017309668 2.893614e-01 4.300439e-01 21 32681496 32681648 153 - 1.309 1.297 -0.042
ENSG00000159082 E034 14.1248792 0.0013048157 7.897934e-02 1.578828e-01 21 32684038 32684119 82 - 1.165 1.061 -0.374
ENSG00000159082 E035 23.8432506 0.0008185224 3.408046e-02 7.991271e-02 21 32685748 32685917 170 - 1.377 1.284 -0.323
ENSG00000159082 E036 20.3040525 0.0219249798 1.312460e-01 2.358872e-01 21 32686978 32687074 97 - 1.316 1.218 -0.346
ENSG00000159082 E037 21.1211643 0.0175072870 7.726492e-02 1.551021e-01 21 32688306 32688367 62 - 1.332 1.220 -0.393
ENSG00000159082 E038 17.7691467 0.0049872390 3.223876e-02 7.630985e-02 21 32694228 32694311 84 - 1.270 1.137 -0.472
ENSG00000159082 E039 27.1894486 0.0007689572 5.893940e-04 2.494614e-03 21 32695057 32695225 169 - 1.459 1.271 -0.653
ENSG00000159082 E040 15.8042714 0.0078294649 3.363827e-02 7.903987e-02 21 32695226 32695282 57 - 1.228 1.081 -0.527
ENSG00000159082 E041 23.6593918 0.0118967253 1.040957e-01 1.967454e-01 21 32699838 32700105 268 - 1.373 1.298 -0.262
ENSG00000159082 E042 15.3048616 0.0062298881 1.622880e-02 4.322973e-02 21 32701961 32702047 87 - 1.218 1.040 -0.641
ENSG00000159082 E043 19.5163211 0.0050277400 1.650281e-01 2.817345e-01 21 32726772 32726917 146 - 1.283 1.232 -0.181
ENSG00000159082 E044 0.0000000       21 32726918 32726942 25 -      
ENSG00000159082 E045 0.0000000       21 32727205 32727266 62 -      
ENSG00000159082 E046 5.0585790 0.0031270023 1.441879e-01 2.537007e-01 21 32727837 32727939 103 - 0.791 0.635 -0.643
ENSG00000159082 E047 3.8460046 0.0044968464 2.945827e-01 4.356785e-01 21 32727946 32728040 95 - 0.684 0.575 -0.473