ENSG00000158941

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308511 ENSG00000158941 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR2 protein_coding protein_coding 80.99041 97.65475 71.95791 10.50276 1.952251 -0.4404842 30.710290 52.74906 18.341362 1.722801 0.2603757 -1.5235318 0.36620417 0.5508000 0.2553667 -0.29543333 1.328320e-05 2.669182e-28 FALSE TRUE
ENST00000389279 ENSG00000158941 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR2 protein_coding protein_coding 80.99041 97.65475 71.95791 10.50276 1.952251 -0.4404842 9.911854 13.76864 8.029642 1.707906 0.5184501 -0.7772308 0.12015000 0.1404667 0.1114000 -0.02906667 5.276179e-02 2.669182e-28 FALSE TRUE
ENST00000518989 ENSG00000158941 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR2 protein_coding protein_coding 80.99041 97.65475 71.95791 10.50276 1.952251 -0.4404842 1.701719 0.00000 4.317693 0.000000 0.8135742 8.7574545 0.02404167 0.0000000 0.0595000 0.05950000 2.669182e-28 2.669182e-28 FALSE FALSE
ENST00000521301 ENSG00000158941 HEK293_OSMI2_2hA HEK293_TMG_2hB CCAR2 protein_coding protein_coding 80.99041 97.65475 71.95791 10.50276 1.952251 -0.4404842 28.426702 22.87795 29.770265 6.043709 0.8433849 0.3797684 0.35857500 0.2258667 0.4137000 0.18783333 1.119755e-02 2.669182e-28   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158941 E001 11.4564971 1.555652e-03 4.088586e-02 9.267857e-02 8 22604757 22604762 6 + 1.173 0.975 -0.717
ENSG00000158941 E002 85.5767217 3.895662e-03 1.295043e-02 3.579492e-02 8 22604763 22604790 28 + 1.952 1.839 -0.378
ENSG00000158941 E003 211.9553295 1.623916e-03 1.780026e-04 8.695117e-04 8 22604791 22604842 52 + 2.341 2.233 -0.362
ENSG00000158941 E004 143.0180132 3.341183e-03 2.653869e-04 1.238801e-03 8 22605038 22605418 381 + 2.192 2.053 -0.466
ENSG00000158941 E005 5.1316492 3.687744e-03 1.831409e-02 4.782023e-02 8 22605500 22605559 60 + 0.940 0.633 -1.227
ENSG00000158941 E006 6.3463714 5.842097e-03 1.028321e-02 2.946433e-02 8 22605719 22605735 17 + 1.011 0.692 -1.239
ENSG00000158941 E007 449.3295866 3.551340e-03 4.583410e-05 2.606530e-04 8 22605736 22605831 96 + 2.676 2.555 -0.400
ENSG00000158941 E008 493.7226593 2.796286e-03 4.486969e-06 3.228910e-05 8 22606085 22606176 92 + 2.718 2.595 -0.409
ENSG00000158941 E009 3.1010322 5.117639e-03 9.835639e-01 9.937914e-01 8 22606600 22606606 7 + 0.553 0.566 0.058
ENSG00000158941 E010 449.3854726 2.962999e-03 6.209649e-05 3.417977e-04 8 22606607 22606698 92 + 2.669 2.558 -0.370
ENSG00000158941 E011 0.0000000       8 22606699 22606703 5 +      
ENSG00000158941 E012 0.6256415 1.753343e-02 5.415855e-02 1.165290e-01 8 22606908 22606909 2 + 0.405 0.081 -2.905
ENSG00000158941 E013 468.2460019 2.759734e-03 8.627170e-02 1.694302e-01 8 22606910 22607024 115 + 2.633 2.596 -0.122
ENSG00000158941 E014 319.7797805 1.547597e-04 5.574193e-04 2.375307e-03 8 22607196 22607235 40 + 2.487 2.423 -0.214
ENSG00000158941 E015 492.8615711 3.353773e-04 1.965921e-06 1.531784e-05 8 22607236 22607325 90 + 2.684 2.606 -0.261
ENSG00000158941 E016 562.0322374 2.064218e-04 1.595428e-07 1.558548e-06 8 22607969 22608065 97 + 2.741 2.663 -0.261
ENSG00000158941 E017 0.2924217 2.907852e-02 4.658886e-02   8 22608066 22608077 12 + 0.307 0.000 -12.457
ENSG00000158941 E018 7.1475685 2.845386e-02 9.947895e-04 3.940202e-03 8 22612703 22613016 314 + 1.142 0.707 -1.654
ENSG00000158941 E019 590.0253905 1.269380e-04 2.266599e-03 8.050250e-03 8 22613017 22613136 120 + 2.733 2.695 -0.127
ENSG00000158941 E020 3.3109536 1.308161e-02 4.597368e-02 1.019833e-01 8 22613885 22614091 207 + 0.788 0.486 -1.319
ENSG00000158941 E021 788.6422905 2.076289e-04 1.847130e-07 1.781918e-06 8 22614092 22614314 223 + 2.879 2.813 -0.218
ENSG00000158941 E022 0.5514428 1.966753e-02 3.532104e-01 4.974388e-01 8 22614388 22614389 2 + 0.000 0.209 10.127
ENSG00000158941 E023 545.3481087 1.540767e-04 8.323273e-07 7.032778e-06 8 22614390 22614503 114 + 2.724 2.651 -0.242
ENSG00000158941 E024 2.3917339 6.292574e-03 4.231888e-02 9.530653e-02 8 22614504 22614573 70 + 0.709 0.388 -1.514
ENSG00000158941 E025 625.2426735 1.160821e-04 1.291569e-01 2.330012e-01 8 22614838 22615001 164 + 2.739 2.727 -0.040
ENSG00000158941 E026 608.4437540 4.447131e-04 7.331199e-01 8.244041e-01 8 22615425 22615596 172 + 2.715 2.722 0.024
ENSG00000158941 E027 851.5622754 5.023721e-04 9.727440e-02 1.863218e-01 8 22615682 22615912 231 + 2.877 2.863 -0.046
ENSG00000158941 E028 934.9556985 9.992457e-05 3.362784e-01 4.801077e-01 8 22616012 22616248 237 + 2.905 2.905 0.000
ENSG00000158941 E029 2.5817676 2.354761e-02 8.116441e-01 8.804600e-01 8 22617388 22617419 32 + 0.485 0.539 0.255
ENSG00000158941 E030 801.2107843 1.128229e-04 2.834184e-01 4.235146e-01 8 22617420 22617564 145 + 2.817 2.846 0.096
ENSG00000158941 E031 342.7590199 2.532044e-04 2.526800e-01 3.890720e-01 8 22617696 22617698 3 + 2.442 2.481 0.131
ENSG00000158941 E032 666.8372856 4.893388e-04 1.207682e-01 2.210528e-01 8 22617699 22617778 80 + 2.727 2.770 0.143
ENSG00000158941 E033 6.5114896 6.844309e-02 6.441725e-02 1.340663e-01 8 22618157 22618348 192 + 1.012 0.716 -1.142
ENSG00000158941 E034 808.2979927 8.397338e-04 2.297674e-03 8.143216e-03 8 22618349 22618495 147 + 2.786 2.861 0.250
ENSG00000158941 E035 644.9427942 1.906290e-04 7.160995e-06 4.919143e-05 8 22618617 22618728 112 + 2.674 2.765 0.302
ENSG00000158941 E036 3.0507840 5.303377e-03 3.266715e-01 4.701118e-01 8 22618729 22618826 98 + 0.663 0.514 -0.668
ENSG00000158941 E037 741.5721757 1.362218e-04 3.284741e-13 8.675371e-12 8 22618827 22619015 189 + 2.702 2.833 0.434
ENSG00000158941 E038 745.1709404 1.244471e-03 7.026217e-13 1.767958e-11 8 22619150 22619355 206 + 2.664 2.846 0.604
ENSG00000158941 E039 41.2466594 7.565857e-04 2.947686e-02 7.092349e-02 8 22619356 22619637 282 + 1.645 1.528 -0.399
ENSG00000158941 E040 2252.7425597 2.412458e-03 2.825902e-11 5.467307e-10 8 22619638 22622137 2500 + 3.156 3.326 0.566
ENSG00000158941 E041 0.0000000       8 22622370 22622536 167 +