ENSG00000158863

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289921 ENSG00000158863 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2B protein_coding protein_coding 14.85326 18.34027 10.30166 1.34374 0.4874492 -0.8315256 3.3791756 5.8682395 1.9532695 0.2679226 0.18614059 -1.58212587 0.21828333 0.32136667 0.18893333 -0.13243333 0.0001092319 8.807611e-05 FALSE TRUE
ENST00000462914 ENSG00000158863 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2B protein_coding retained_intron 14.85326 18.34027 10.30166 1.34374 0.4874492 -0.8315256 1.0210793 0.5815170 0.8934689 0.2918766 0.24634229 0.61105532 0.07275833 0.03423333 0.08516667 0.05093333 0.5263258649 8.807611e-05 FALSE FALSE
ENST00000477614 ENSG00000158863 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2B protein_coding retained_intron 14.85326 18.34027 10.30166 1.34374 0.4874492 -0.8315256 1.3207611 1.0975961 1.0445115 0.2759033 0.08142463 -0.07085708 0.09374167 0.05840000 0.10136667 0.04296667 0.1423415238 8.807611e-05 FALSE FALSE
ENST00000498344 ENSG00000158863 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2B protein_coding retained_intron 14.85326 18.34027 10.30166 1.34374 0.4874492 -0.8315256 0.9248508 0.4990421 0.7635075 0.2656776 0.21741455 0.60363013 0.06479583 0.02566667 0.07330000 0.04763333 0.4754746053 8.807611e-05 FALSE TRUE
ENST00000523633 ENSG00000158863 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2B protein_coding retained_intron 14.85326 18.34027 10.30166 1.34374 0.4874492 -0.8315256 4.6077969 7.1174562 2.6788037 0.5877316 0.12748991 -1.40642285 0.29713750 0.38843333 0.26196667 -0.12646667 0.0186231510 8.807611e-05 FALSE FALSE
MSTRG.31241.7 ENSG00000158863 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP2B protein_coding   14.85326 18.34027 10.30166 1.34374 0.4874492 -0.8315256 1.6835654 1.5178287 1.6433453 0.3177242 0.07530159 0.11390527 0.12216667 0.08136667 0.16090000 0.07953333 0.0257609165 8.807611e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158863 E001 0.2966881 0.0295462963 5.366284e-02   8 22089149 22089149 1 + 0.301 0.000 -12.151
ENSG00000158863 E002 0.8450104 0.0158995546 1.667144e-01 2.839174e-01 8 22089150 22089158 9 + 0.398 0.154 -1.822
ENSG00000158863 E003 1.1416985 0.0447410311 3.050969e-02 7.296651e-02 8 22089159 22089164 6 + 0.544 0.154 -2.556
ENSG00000158863 E004 1.8372698 0.0281979337 2.717114e-02 6.634367e-02 8 22089165 22089171 7 + 0.653 0.267 -2.039
ENSG00000158863 E005 4.1537739 0.0179413576 2.989416e-02 7.175756e-02 8 22089172 22089183 12 + 0.875 0.550 -1.350
ENSG00000158863 E006 4.3354783 0.0455606585 6.372904e-02 1.329070e-01 8 22089184 22089185 2 + 0.875 0.577 -1.228
ENSG00000158863 E007 5.1030702 0.0472540149 3.507540e-02 8.179280e-02 8 22089186 22089202 17 + 0.954 0.623 -1.323
ENSG00000158863 E008 5.2503193 0.0417898839 2.083858e-02 5.324727e-02 8 22089203 22089207 5 + 0.977 0.623 -1.411
ENSG00000158863 E009 5.4320236 0.0648316090 4.138500e-02 9.359944e-02 8 22089208 22089210 3 + 0.977 0.645 -1.314
ENSG00000158863 E010 18.2390012 0.0174063318 6.612001e-02 1.369110e-01 8 22089211 22089298 88 + 1.352 1.167 -0.649
ENSG00000158863 E011 6.3753179 0.0034199126 6.942397e-04 2.877872e-03 8 22089761 22089788 28 + 1.079 0.663 -1.610
ENSG00000158863 E012 7.1449836 0.0028292957 9.859969e-03 2.841927e-02 8 22089789 22089854 66 + 1.061 0.753 -1.171
ENSG00000158863 E013 1.3651314 0.0237227232 6.475239e-01 7.591760e-01 8 22093742 22093794 53 + 0.398 0.314 -0.501
ENSG00000158863 E014 29.9115351 0.0078520056 6.039985e-01 7.246581e-01 8 22094440 22094518 79 + 1.455 1.415 -0.136
ENSG00000158863 E015 2.0574779 0.0072438620 1.042747e-02 2.981097e-02 8 22094519 22094595 77 + 0.000 0.523 14.483
ENSG00000158863 E016 5.7057632 0.0048808753 8.425287e-01 9.018789e-01 8 22094596 22094853 258 + 0.740 0.770 0.118
ENSG00000158863 E017 2.7969587 0.0114066644 6.253635e-01 7.415237e-01 8 22094854 22096336 1483 + 0.602 0.522 -0.366
ENSG00000158863 E018 42.2054389 0.0005019848 7.172703e-01 8.127088e-01 8 22096337 22096509 173 + 1.591 1.571 -0.069
ENSG00000158863 E019 1.1886253 0.2147469018 2.577962e-01 3.949659e-01 8 22096510 22096543 34 + 0.478 0.259 -1.298
ENSG00000158863 E020 16.2566307 0.0131251942 1.438250e-04 7.201969e-04 8 22096544 22097045 502 + 1.415 1.043 -1.318
ENSG00000158863 E021 23.4346318 0.0009472200 5.830476e-01 7.072437e-01 8 22097516 22097565 50 + 1.362 1.320 -0.144
ENSG00000158863 E022 22.6021432 0.0060611607 5.347141e-01 6.667236e-01 8 22097566 22097620 55 + 1.352 1.299 -0.184
ENSG00000158863 E023 2.3562595 0.0148319057 6.484304e-02 1.347792e-01 8 22097621 22097716 96 + 0.699 0.394 -1.434
ENSG00000158863 E024 37.4961533 0.0243726657 6.395728e-01 7.529434e-01 8 22097717 22097839 123 + 1.567 1.519 -0.166
ENSG00000158863 E025 0.4396707 0.0239136828 1.406550e-02 3.837312e-02 8 22097935 22098067 133 + 0.398 0.000 -14.999
ENSG00000158863 E026 73.1028743 0.0004231560 3.492437e-01 4.934751e-01 8 22098068 22098310 243 + 1.842 1.801 -0.137
ENSG00000158863 E027 69.6858147 0.0003793742 6.710492e-02 1.385473e-01 8 22098423 22098619 197 + 1.848 1.767 -0.275
ENSG00000158863 E028 53.5455572 0.0004251150 6.643190e-04 2.768074e-03 8 22098948 22099056 109 + 1.796 1.626 -0.574
ENSG00000158863 E029 0.9297165 0.0935278982 8.661597e-02 1.699847e-01 8 22099057 22099124 68 + 0.478 0.153 -2.247
ENSG00000158863 E030 50.2944592 0.0004878100 4.294552e-05 2.457857e-04 8 22099284 22099360 77 + 1.792 1.583 -0.710
ENSG00000158863 E031 53.1868212 0.0083618356 5.292744e-01 6.620718e-01 8 22099704 22099818 115 + 1.695 1.660 -0.117
ENSG00000158863 E032 44.4443466 0.0107689003 4.010235e-01 5.446969e-01 8 22099819 22099893 75 + 1.538 1.612 0.254
ENSG00000158863 E033 1.7767756 0.0103879794 1.864020e-01 3.092288e-01 8 22100138 22100593 456 + 0.544 0.314 -1.236
ENSG00000158863 E034 77.1567007 0.0021441979 4.028860e-01 5.466856e-01 8 22100594 22100739 146 + 1.857 1.819 -0.129
ENSG00000158863 E035 88.8196139 0.0003067206 8.828359e-02 1.724995e-01 8 22100844 22100972 129 + 1.942 1.875 -0.226
ENSG00000158863 E036 6.4001210 0.0045318948 8.910331e-03 2.605797e-02 8 22100973 22101181 209 + 1.041 0.719 -1.240
ENSG00000158863 E037 11.3384983 0.0026891456 6.551281e-04 2.734710e-03 8 22101190 22101439 250 + 1.255 0.914 -1.237
ENSG00000158863 E038 58.3474867 0.0037466229 1.214657e-01 2.220205e-01 8 22101440 22101482 43 + 1.775 1.689 -0.289
ENSG00000158863 E039 59.4689066 0.0005500357 5.613850e-01 6.892146e-01 8 22101483 22101530 48 + 1.744 1.716 -0.094
ENSG00000158863 E040 94.9433932 0.0003482293 7.936987e-01 8.681315e-01 8 22101708 22101851 144 + 1.914 1.926 0.040
ENSG00000158863 E041 11.1360409 0.0020335075 2.290974e-03 8.122204e-03 8 22101852 22102174 323 + 1.230 0.925 -1.109
ENSG00000158863 E042 89.2817533 0.0008317060 1.017799e-02 2.920217e-02 8 22102175 22102315 141 + 1.803 1.919 0.390
ENSG00000158863 E043 0.6255398 0.0188625573 8.472066e-01 9.050914e-01 8 22102527 22102527 1 + 0.176 0.213 0.343
ENSG00000158863 E044 86.5968713 0.0003307517 1.887776e-03 6.876114e-03 8 22102528 22102628 101 + 1.775 1.912 0.465
ENSG00000158863 E045 186.7018604 0.0062166457 1.007797e-01 1.916427e-01 8 22102793 22103185 393 + 2.152 2.235 0.277
ENSG00000158863 E046 278.4348394 0.0002048340 1.210760e-08 1.470823e-07 8 22103186 22103943 758 + 2.281 2.418 0.456
ENSG00000158863 E047 111.6783114 0.0003106024 4.021403e-03 1.320145e-02 8 22103944 22104068 125 + 1.908 2.020 0.373
ENSG00000158863 E048 111.7507235 0.0021329225 9.008261e-06 6.052160e-05 8 22104069 22105207 1139 + 1.839 2.040 0.675