ENSG00000158813

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374552 ENSG00000158813 HEK293_OSMI2_2hA HEK293_TMG_2hB EDA protein_coding protein_coding 6.112702 6.826563 4.842174 0.3357785 0.1105526 -0.4946398 0.6816455 1.0181358 0.000000 1.0181358 0.0000000 -6.6838870 0.11732083 0.1603000 0.0000000 -0.1603000 0.88520603 0.003080301 FALSE TRUE
ENST00000374553 ENSG00000158813 HEK293_OSMI2_2hA HEK293_TMG_2hB EDA protein_coding protein_coding 6.112702 6.826563 4.842174 0.3357785 0.1105526 -0.4946398 1.7208701 0.6488598 2.805157 0.6488598 0.4234873 2.0951718 0.29300833 0.0868000 0.5778333 0.4910333 0.04625484 0.003080301 FALSE TRUE
ENST00000616899 ENSG00000158813 HEK293_OSMI2_2hA HEK293_TMG_2hB EDA protein_coding protein_coding 6.112702 6.826563 4.842174 0.3357785 0.1105526 -0.4946398 2.8093191 3.3481968 1.856457 0.3796056 0.4145339 -0.8473849 0.44908333 0.4907333 0.3859000 -0.1048333 0.64645119 0.003080301 FALSE TRUE
MSTRG.34392.2 ENSG00000158813 HEK293_OSMI2_2hA HEK293_TMG_2hB EDA protein_coding   6.112702 6.826563 4.842174 0.3357785 0.1105526 -0.4946398 0.5777219 1.3558758 0.000000 0.7005914 0.0000000 -7.0936825 0.08655417 0.1942667 0.0000000 -0.1942667 0.17240569 0.003080301 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158813 E001 0.4804688 0.0210543908 3.924864e-01 5.364591e-01 X 69616067 69616112 46 + 0.237 0.111 -1.316
ENSG00000158813 E002 0.6277178 0.0221097837 1.846253e-01 3.070126e-01 X 69616113 69616116 4 + 0.320 0.111 -1.901
ENSG00000158813 E003 10.1518716 0.0017005219 7.767616e-01 8.562565e-01 X 69616117 69616185 69 + 0.987 1.061 0.270
ENSG00000158813 E004 17.3111615 0.0018790123 6.828906e-01 7.862239e-01 X 69616186 69616289 104 + 1.201 1.281 0.282
ENSG00000158813 E005 26.1458606 0.0043589330 6.164732e-01 7.345173e-01 X 69616290 69616495 206 + 1.371 1.454 0.287
ENSG00000158813 E006 33.5364035 0.0125647171 5.740372e-01 6.999045e-01 X 69616496 69616704 209 + 1.523 1.524 0.005
ENSG00000158813 E007 2.0316294 0.3593684556 1.542830e-01 2.674786e-01 X 69616705 69617299 595 + 0.135 0.586 2.970
ENSG00000158813 E008 0.0000000       X 69620410 69620428 19 +      
ENSG00000158813 E009 0.0000000       X 69620429 69620455 27 +      
ENSG00000158813 E010 0.0000000       X 69620456 69620505 50 +      
ENSG00000158813 E011 0.1482932 0.0415431027 6.520668e-01   X 69620896 69620946 51 + 0.000 0.111 8.847
ENSG00000158813 E012 0.4772466 0.0204536348 7.735129e-01 8.538637e-01 X 69670210 69670293 84 + 0.135 0.199 0.683
ENSG00000158813 E013 0.0000000       X 69687613 69687646 34 +      
ENSG00000158813 E014 0.0000000       X 69729143 69729178 36 +      
ENSG00000158813 E015 0.0000000       X 69743009 69743052 44 +      
ENSG00000158813 E016 0.0000000       X 69749705 69749743 39 +      
ENSG00000158813 E017 0.0000000       X 69756875 69756904 30 +      
ENSG00000158813 E018 2.6130628 0.1150965589 2.773075e-01 4.168623e-01 X 69860857 69861193 337 + 0.389 0.627 1.155
ENSG00000158813 E019 0.1515154 0.0429565406 3.589628e-01   X 69957024 69957026 3 + 0.135 0.000 -9.992
ENSG00000158813 E020 23.1294669 0.0008833126 3.543703e-02 8.249190e-02 X 69957027 69957132 106 + 1.428 1.325 -0.357
ENSG00000158813 E021 0.3666179 0.0293068241 8.123102e-01 8.809657e-01 X 69957133 69957504 372 + 0.135 0.111 -0.313
ENSG00000158813 E022 13.0656443 0.0355201899 3.556593e-01 5.000341e-01 X 70023218 70023241 24 + 1.181 1.105 -0.273
ENSG00000158813 E023 25.9531220 0.0068645042 9.416289e-02 1.816401e-01 X 70027857 70028036 180 + 1.467 1.387 -0.278
ENSG00000158813 E024 16.1725843 0.0137821211 6.881339e-02 1.414059e-01 X 70029504 70029538 35 + 1.299 1.168 -0.459
ENSG00000158813 E025 18.9452173 0.0102150045 8.952238e-02 1.744004e-01 X 70030469 70030520 52 + 1.351 1.247 -0.364
ENSG00000158813 E026 12.8705752 0.0017092163 7.548171e-02 1.522841e-01 X 70033398 70033406 9 + 1.201 1.082 -0.425
ENSG00000158813 E027 20.7623390 0.0009493394 1.726628e-02 4.553679e-02 X 70033407 70033486 80 + 1.404 1.274 -0.451
ENSG00000158813 E028 13.1161237 0.0014505871 2.618517e-03 9.122290e-03 X 70033487 70033522 36 + 1.265 1.038 -0.814
ENSG00000158813 E029 2.2529780 0.0831175747 4.739128e-01 6.128002e-01 X 70033523 70033528 6 + 0.549 0.444 -0.513
ENSG00000158813 E030 38.8575879 0.0005923000 1.710666e-03 6.315545e-03 X 70035358 70035589 232 + 1.663 1.538 -0.425
ENSG00000158813 E031 105.4275034 0.0020524357 2.288292e-03 8.114368e-03 X 70035590 70036359 770 + 2.054 1.987 -0.226
ENSG00000158813 E032 558.8785104 0.0039478653 1.225604e-06 9.988684e-06 X 70036360 70039472 3113 + 2.658 2.786 0.429