ENSG00000158796

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368006 ENSG00000158796 HEK293_OSMI2_2hA HEK293_TMG_2hB DEDD protein_coding protein_coding 35.11935 49.34513 27.04584 1.880234 0.873224 -0.8672599 17.4451428 30.178214 11.417032 2.0875999 0.67289824 -1.40153462 0.47496250 0.61190000 0.42236667 -0.18953333 7.472047e-03 1.374184e-25 FALSE TRUE
ENST00000458050 ENSG00000158796 HEK293_OSMI2_2hA HEK293_TMG_2hB DEDD protein_coding protein_coding 35.11935 49.34513 27.04584 1.880234 0.873224 -0.8672599 2.5597019 5.887925 0.000000 0.7943913 0.00000000 -9.20406376 0.05931667 0.11966667 0.00000000 -0.11966667 1.625719e-25 1.374184e-25 FALSE TRUE
ENST00000463227 ENSG00000158796 HEK293_OSMI2_2hA HEK293_TMG_2hB DEDD protein_coding processed_transcript 35.11935 49.34513 27.04584 1.880234 0.873224 -0.8672599 1.9765255 0.000000 2.747706 0.0000000 0.46284627 8.10732501 0.06787500 0.00000000 0.10106667 0.10106667 1.374184e-25 1.374184e-25 FALSE FALSE
ENST00000464113 ENSG00000158796 HEK293_OSMI2_2hA HEK293_TMG_2hB DEDD protein_coding protein_coding 35.11935 49.34513 27.04584 1.880234 0.873224 -0.8672599 0.5075665 0.000000 1.359304 0.0000000 0.41286271 7.09729902 0.01769583 0.00000000 0.05113333 0.05113333 3.208325e-09 1.374184e-25 FALSE FALSE
ENST00000472996 ENSG00000158796 HEK293_OSMI2_2hA HEK293_TMG_2hB DEDD protein_coding processed_transcript 35.11935 49.34513 27.04584 1.880234 0.873224 -0.8672599 2.3111628 1.637543 1.694015 0.2941882 0.35898762 0.04862143 0.07110417 0.03356667 0.06196667 0.02840000 2.274624e-01 1.374184e-25   FALSE
ENST00000486041 ENSG00000158796 HEK293_OSMI2_2hA HEK293_TMG_2hB DEDD protein_coding processed_transcript 35.11935 49.34513 27.04584 1.880234 0.873224 -0.8672599 3.3130262 4.791750 3.748598 0.4677664 0.09636301 -0.35336567 0.09909583 0.09800000 0.13910000 0.04110000 2.109381e-01 1.374184e-25 FALSE TRUE
ENST00000490843 ENSG00000158796 HEK293_OSMI2_2hA HEK293_TMG_2hB DEDD protein_coding protein_coding 35.11935 49.34513 27.04584 1.880234 0.873224 -0.8672599 4.6781609 3.786294 3.857975 1.9483908 0.57801126 0.02698676 0.14054583 0.07463333 0.14290000 0.06826667 6.916156e-01 1.374184e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158796 E001 0.3268771 0.0293492637 4.828300e-01   1 161120974 161120976 3 - 0.183 0.080 -1.378
ENSG00000158796 E002 30.3379519 0.0006831403 3.710022e-01 5.154088e-01 1 161120977 161121143 167 - 1.382 1.451 0.238
ENSG00000158796 E003 446.9049309 0.0003262987 3.237592e-22 2.635806e-20 1 161121144 161121743 600 - 2.415 2.628 0.712
ENSG00000158796 E004 205.9864941 0.0024390129 1.461165e-07 1.437618e-06 1 161121744 161121786 43 - 2.085 2.291 0.688
ENSG00000158796 E005 349.0080988 0.0010070344 6.009051e-09 7.735249e-08 1 161121787 161121929 143 - 2.352 2.512 0.533
ENSG00000158796 E006 257.1043908 0.0039924613 5.138054e-05 2.886510e-04 1 161121930 161122024 95 - 2.214 2.382 0.560
ENSG00000158796 E007 419.4016701 0.0031230462 7.778809e-04 3.179581e-03 1 161122025 161122241 217 - 2.468 2.583 0.381
ENSG00000158796 E008 210.8801544 0.0001852635 5.554849e-01 6.843362e-01 1 161122242 161122262 21 - 2.269 2.257 -0.041
ENSG00000158796 E009 316.7764077 0.0001540400 9.922753e-02 1.893011e-01 1 161122263 161122332 70 - 2.460 2.428 -0.109
ENSG00000158796 E010 224.8697420 0.0003879621 2.292171e-01 3.615051e-01 1 161122333 161122350 18 - 2.310 2.281 -0.096
ENSG00000158796 E011 462.2491676 0.0007921231 5.883900e-01 7.115872e-01 1 161122351 161122523 173 - 2.606 2.598 -0.027
ENSG00000158796 E012 5.6538480 0.0033110835 9.626879e-03 2.784657e-02 1 161122985 161123074 90 - 0.997 0.666 -1.297
ENSG00000158796 E013 343.1516832 0.0001765331 9.046878e-04 3.630537e-03 1 161123075 161123174 100 - 2.521 2.454 -0.220
ENSG00000158796 E014 229.3713489 0.0001846665 4.889946e-05 2.762197e-04 1 161123175 161123221 47 - 2.370 2.270 -0.333
ENSG00000158796 E015 271.9351873 0.0001706859 6.720573e-08 7.058390e-07 1 161123839 161123946 108 - 2.458 2.336 -0.407
ENSG00000158796 E016 0.3332198 0.0296652343 4.821589e-01   1 161124133 161124137 5 - 0.183 0.080 -1.379
ENSG00000158796 E017 194.7356379 0.0012591105 7.459405e-04 3.064164e-03 1 161124138 161124210 73 - 2.301 2.197 -0.346
ENSG00000158796 E018 239.4867452 0.0021178968 5.643221e-02 1.204786e-01 1 161124211 161124339 129 - 2.357 2.298 -0.197
ENSG00000158796 E019 226.5425702 0.0006122777 1.288227e-01 2.325133e-01 1 161124340 161124413 74 - 2.318 2.278 -0.131
ENSG00000158796 E020 249.8133157 0.0041728196 4.806014e-02 1.057351e-01 1 161124414 161124526 113 - 2.385 2.312 -0.244
ENSG00000158796 E021 145.6285877 0.0088860794 7.786605e-02 1.560520e-01 1 161130815 161130843 29 - 2.165 2.072 -0.312
ENSG00000158796 E022 112.1285884 0.0092266492 1.362579e-02 3.736884e-02 1 161130844 161130847 4 - 2.085 1.946 -0.468
ENSG00000158796 E023 6.0777008 0.0026820044 3.017093e-05 1.794428e-04 1 161130954 161131005 52 - 1.116 0.605 -1.995
ENSG00000158796 E024 19.7255030 0.0064546887 4.827557e-07 4.281878e-06 1 161131006 161131182 177 - 1.525 1.099 -1.494
ENSG00000158796 E025 2.9756600 0.0777380130 2.150883e-03 7.692770e-03 1 161132106 161132390 285 - 0.893 0.345 -2.493
ENSG00000158796 E026 18.0011523 0.0022429337 9.970588e-01 1.000000e+00 1 161132391 161132550 160 - 1.210 1.213 0.011
ENSG00000158796 E027 95.8684306 0.0152791533 3.564790e-02 8.290129e-02 1 161132551 161132688 138 - 2.021 1.878 -0.480