ENSG00000158792

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289805 ENSG00000158792 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA2L protein_coding protein_coding 17.85513 33.33606 10.38725 2.590279 0.1766005 -1.681314 14.94574 28.595661 7.999190 2.0915710 0.1032074 -1.8365724 0.8246375 0.8587333 0.7704 -0.08833333 0.01026204 0.01026204 FALSE  
ENST00000569918 ENSG00000158792 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA2L protein_coding protein_coding 17.85513 33.33606 10.38725 2.590279 0.1766005 -1.681314 2.90154 4.740399 2.388063 0.6461858 0.1592860 -0.9861788 0.1751125 0.1412667 0.2296 0.08833333 0.01029058 0.01026204 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158792 E001 385.59173 0.0038662715 0.007313627 0.02203404 16 89696357 89696864 508 - 2.392 2.487 0.316
ENSG00000158792 E002 820.05323 0.0001677533 0.111297627 0.20745603 16 89696865 89698067 1203 - 2.775 2.799 0.079
ENSG00000158792 E003 124.05965 0.0015149355 0.694504415 0.79531280 16 89698068 89698194 127 - 1.959 1.981 0.073
ENSG00000158792 E004 125.49955 0.0003832209 0.004323607 0.01405157 16 89698195 89698305 111 - 2.061 1.959 -0.343
ENSG00000158792 E005 153.42188 0.0038635849 0.010314990 0.02954333 16 89700930 89701233 304 - 2.150 2.049 -0.338
ENSG00000158792 E006 38.67078 0.0005971518 0.005996743 0.01860158 16 89701491 89701627 137 - 1.619 1.446 -0.594
ENSG00000158792 E007 53.78692 0.0205729785 0.078122611 0.15645747 16 89701628 89701705 78 - 1.729 1.593 -0.464