ENSG00000158717

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312838 ENSG00000158717 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF166 protein_coding protein_coding 37.53786 53.97152 21.76421 3.893165 0.5622939 -1.309845 26.416428 38.2308931 14.924686 3.86014397 0.38579209 -1.3564494 0.6859875 0.70563333 0.68640000 -0.01923333 8.708593e-01 2.275872e-11 FALSE TRUE
ENST00000537718 ENSG00000158717 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF166 protein_coding protein_coding 37.53786 53.97152 21.76421 3.893165 0.5622939 -1.309845 1.510984 6.6933552 0.000000 1.66087749 0.00000000 -9.3887396 0.0329250 0.12780000 0.00000000 -0.12780000 2.275872e-11 2.275872e-11 FALSE TRUE
ENST00000564894 ENSG00000158717 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF166 protein_coding processed_transcript 37.53786 53.97152 21.76421 3.893165 0.5622939 -1.309845 3.782445 3.9814895 2.418796 0.36667716 0.15936047 -0.7166860 0.1070417 0.07356667 0.11093333 0.03736667 6.391231e-03 2.275872e-11 FALSE FALSE
ENST00000568683 ENSG00000158717 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF166 protein_coding protein_coding 37.53786 53.97152 21.76421 3.893165 0.5622939 -1.309845 1.842307 1.3929586 1.158309 0.06171094 0.07011616 -0.2640501 0.0549500 0.02593333 0.05320000 0.02726667 4.117859e-04 2.275872e-11 FALSE TRUE
ENST00000569478 ENSG00000158717 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF166 protein_coding processed_transcript 37.53786 53.97152 21.76421 3.893165 0.5622939 -1.309845 1.880051 0.9507132 1.753209 0.95071321 0.89752038 0.8760256 0.0515875 0.01586667 0.08236667 0.06650000 4.334732e-01 2.275872e-11   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158717 E001 0.7394768 0.0203869696 2.767060e-01 4.161760e-01 16 88696499 88696500 2 - 0.001 0.245 9.122
ENSG00000158717 E002 0.7394768 0.0203869696 2.767060e-01 4.161760e-01 16 88696501 88696501 1 - 0.000 0.245 11.280
ENSG00000158717 E003 8.8961371 0.0018641810 7.146457e-05 3.872751e-04 16 88696502 88696535 34 - 0.326 0.996 2.996
ENSG00000158717 E004 183.3062192 0.0007775896 1.040162e-15 3.917606e-14 16 88696536 88696638 103 - 1.926 2.232 1.026
ENSG00000158717 E005 271.7668503 0.0016269293 2.667329e-13 7.141287e-12 16 88696639 88696709 71 - 2.141 2.396 0.852
ENSG00000158717 E006 324.7455095 0.0028166303 1.358418e-11 2.769238e-10 16 88696710 88696793 84 - 2.223 2.473 0.837
ENSG00000158717 E007 524.8007745 0.0004894701 7.800592e-12 1.653680e-10 16 88696794 88697133 340 - 2.515 2.664 0.498
ENSG00000158717 E008 252.0086583 0.0015636597 5.146223e-01 6.493536e-01 16 88697134 88697295 162 - 2.296 2.323 0.090
ENSG00000158717 E009 196.5857305 0.0029098505 6.011585e-01 7.222938e-01 16 88697296 88697393 98 - 2.188 2.215 0.091
ENSG00000158717 E010 228.1117137 0.0025259229 8.804268e-01 9.273146e-01 16 88697394 88697478 85 - 2.272 2.274 0.008
ENSG00000158717 E011 306.5614618 0.0002579341 5.509601e-01 6.805084e-01 16 88697479 88697633 155 - 2.408 2.399 -0.030
ENSG00000158717 E012 14.0483857 0.0124147129 1.809662e-03 6.629829e-03 16 88697634 88697933 300 - 1.325 1.005 -1.144
ENSG00000158717 E013 17.8700702 0.0039561816 3.347009e-03 1.128278e-02 16 88697934 88698501 568 - 1.389 1.136 -0.889
ENSG00000158717 E014 270.3244163 0.0002023650 2.632848e-01 4.011623e-01 16 88698502 88698609 108 - 2.322 2.356 0.113
ENSG00000158717 E015 279.6031234 0.0006351249 4.071762e-01 5.507833e-01 16 88698971 88699070 100 - 2.377 2.362 -0.053
ENSG00000158717 E016 177.2296236 0.0004408485 1.691203e-01 2.870420e-01 16 88699071 88699085 15 - 2.196 2.158 -0.126
ENSG00000158717 E017 251.6332380 0.0001942996 3.672364e-02 8.494626e-02 16 88699620 88699687 68 - 2.354 2.306 -0.161
ENSG00000158717 E018 215.4018432 0.0002646149 3.425967e-03 1.151338e-02 16 88699688 88699732 45 - 2.309 2.234 -0.253
ENSG00000158717 E019 26.5903204 0.0014384560 1.053290e-08 1.292710e-07 16 88699733 88700056 324 - 1.627 1.229 -1.375
ENSG00000158717 E020 9.0558969 0.0033826170 3.793892e-04 1.694945e-03 16 88700547 88700603 57 - 1.191 0.800 -1.452
ENSG00000158717 E021 17.2448473 0.0012264055 7.388164e-05 3.987424e-04 16 88700756 88700940 185 - 1.417 1.086 -1.169
ENSG00000158717 E022 191.5121426 0.0002491440 1.611698e-04 7.971876e-04 16 88701262 88701296 35 - 2.277 2.173 -0.348
ENSG00000158717 E023 172.2525729 0.0002712873 1.409444e-05 9.043383e-05 16 88701297 88701316 20 - 2.249 2.123 -0.422
ENSG00000158717 E024 216.7879924 0.0002726207 1.727818e-04 8.471929e-04 16 88701317 88701418 102 - 2.327 2.229 -0.326
ENSG00000158717 E025 33.4681502 0.0006351793 1.152771e-03 4.480603e-03 16 88701419 88701650 232 - 1.603 1.396 -0.711
ENSG00000158717 E026 12.9289004 0.0290105384 3.509115e-03 1.175249e-02 16 88702773 88702789 17 - 1.312 0.963 -1.255
ENSG00000158717 E027 40.0575052 0.0152305958 7.805430e-05 4.187928e-04 16 88702790 88703134 345 - 1.750 1.437 -1.067
ENSG00000158717 E028 46.6830498 0.0069044938 2.832085e-07 2.634698e-06 16 88703135 88703617 483 - 1.829 1.498 -1.125
ENSG00000158717 E029 106.7689555 0.0007647334 5.382285e-04 2.303062e-03 16 88706171 88706211 41 - 2.046 1.914 -0.441
ENSG00000158717 E030 96.1957725 0.0072841002 6.589559e-07 5.691753e-06 16 88706212 88706408 197 - 2.093 1.828 -0.892