ENSG00000158711

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289703 ENSG00000158711 HEK293_OSMI2_2hA HEK293_TMG_2hB ELK4 protein_coding protein_coding 4.505894 2.072889 5.998208 0.1355289 0.4965185 1.528348 0.5047121 0.58269608 0.4848908 0.034225477 0.1116908 -0.2601823 0.14847083 0.28203333 0.07920000 -0.2028333 1.759495e-05 1.759495e-05 FALSE TRUE
ENST00000357992 ENSG00000158711 HEK293_OSMI2_2hA HEK293_TMG_2hB ELK4 protein_coding protein_coding 4.505894 2.072889 5.998208 0.1355289 0.4965185 1.528348 2.6476735 1.01286104 3.9108898 0.025166641 0.1635033 1.9385709 0.58139583 0.49406667 0.65736667 0.1633000 1.227191e-01 1.759495e-05 FALSE TRUE
ENST00000468523 ENSG00000158711 HEK293_OSMI2_2hA HEK293_TMG_2hB ELK4 protein_coding protein_coding 4.505894 2.072889 5.998208 0.1355289 0.4965185 1.528348 0.7502085 0.08454002 0.5595642 0.084540020 0.2812632 2.5908615 0.11947917 0.03606667 0.08866667 0.0526000 7.432522e-01 1.759495e-05 FALSE FALSE
ENST00000616704 ENSG00000158711 HEK293_OSMI2_2hA HEK293_TMG_2hB ELK4 protein_coding nonsense_mediated_decay 4.505894 2.072889 5.998208 0.1355289 0.4965185 1.528348 0.2490174 0.14013046 0.4594277 0.008842107 0.1330371 1.6446864 0.06172917 0.06820000 0.07460000 0.0064000 1.000000e+00 1.759495e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158711 E001 2.9056008 0.0055150628 9.602528e-02 1.844028e-01 1 205597511 205597555 45 - 0.464 0.735 1.210
ENSG00000158711 E002 8.8853504 0.0019420017 7.286249e-01 8.210553e-01 1 205597556 205597789 234 - 0.947 0.994 0.174
ENSG00000158711 E003 6.5825760 0.0028209812 4.403544e-01 5.820320e-01 1 205597790 205597862 73 - 0.875 0.777 -0.386
ENSG00000158711 E004 10.6508926 0.0016590877 5.838838e-01 7.079136e-01 1 205598455 205598649 195 - 1.016 1.081 0.238
ENSG00000158711 E005 5.4732921 0.0034914941 1.542780e-01 2.674734e-01 1 205599825 205599925 101 - 0.717 0.913 0.772
ENSG00000158711 E006 0.8136755 0.0145928713 4.998096e-01 6.360785e-01 1 205599926 205600194 269 - 0.197 0.324 0.947
ENSG00000158711 E007 7.5669325 0.0165686765 6.336586e-01 7.483199e-01 1 205600651 205600794 144 - 0.876 0.942 0.250
ENSG00000158711 E008 4.5346921 0.0666892110 4.859473e-01 6.237720e-01 1 205603201 205603353 153 - 0.667 0.780 0.461
ENSG00000158711 E009 400.2290597 0.0003027489 2.814545e-01 4.213586e-01 1 205607943 205613099 5157 - 2.556 2.580 0.079
ENSG00000158711 E010 11.9715490 0.0014651180 2.978321e-05 1.773826e-04 1 205613100 205613302 203 - 1.175 0.636 -2.073
ENSG00000158711 E011 155.1170399 0.0003675379 3.313780e-18 1.710588e-16 1 205613303 205616477 3175 - 2.219 1.936 -0.950
ENSG00000158711 E012 41.1907060 0.0005218293 7.369915e-01 8.272846e-01 1 205616478 205616644 167 - 1.588 1.574 -0.046
ENSG00000158711 E013 33.1488689 0.0009300390 6.295834e-01 7.449421e-01 1 205618957 205619073 117 - 1.500 1.474 -0.089
ENSG00000158711 E014 22.9076177 0.0135682125 9.956700e-11 1.757446e-09 1 205619268 205619965 698 - 1.083 1.659 2.006
ENSG00000158711 E015 122.1364118 0.0016734927 3.255132e-04 1.482891e-03 1 205619966 205620613 648 - 2.007 2.144 0.457
ENSG00000158711 E016 49.6625033 0.0009469242 7.621180e-02 1.534466e-01 1 205620614 205620838 225 - 1.636 1.738 0.343
ENSG00000158711 E017 35.9642696 0.0006445866 4.680734e-01 6.075080e-01 1 205623676 205623891 216 - 1.538 1.498 -0.138
ENSG00000158711 E018 0.1515154 0.0423779699 1.000000e+00   1 205625632 205625667 36 - 0.076 0.000 -7.486
ENSG00000158711 E019 15.6388120 0.0018898630 3.630880e-01 5.075104e-01 1 205631632 205633055 1424 - 1.202 1.120 -0.294