ENSG00000158691

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361028 ENSG00000158691 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN12 protein_coding protein_coding 5.023592 1.219739 8.608007 0.1158096 0.3635364 2.809002 0.6482109 0.31467609 0.9811064 0.02353516 0.02729101 1.610039 0.16470833 0.2605333 0.11460000 -0.14593333 0.01366310 0.00453364 FALSE TRUE
ENST00000396827 ENSG00000158691 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN12 protein_coding protein_coding 5.023592 1.219739 8.608007 0.1158096 0.3635364 2.809002 2.1840422 0.53045372 3.4699784 0.11543142 0.22388143 2.686835 0.43272917 0.4257333 0.40243333 -0.02330000 0.87192272 0.00453364 TRUE TRUE
ENST00000684592 ENSG00000158691 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN12 protein_coding protein_coding 5.023592 1.219739 8.608007 0.1158096 0.3635364 2.809002 0.8588927 0.22439110 1.0808294 0.05548564 0.06164388 2.218436 0.20350833 0.1892667 0.12636667 -0.06290000 0.54498681 0.00453364 FALSE TRUE
MSTRG.27894.1 ENSG00000158691 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN12 protein_coding   5.023592 1.219739 8.608007 0.1158096 0.3635364 2.809002 0.4999432 0.07985032 1.1140904 0.02664533 0.06188971 3.645091 0.07526250 0.0685000 0.12930000 0.06080000 0.25249696 0.00453364 TRUE TRUE
MSTRG.27894.5 ENSG00000158691 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN12 protein_coding   5.023592 1.219739 8.608007 0.1158096 0.3635364 2.809002 0.2976294 0.00000000 0.6716684 0.00000000 0.13665701 6.090998 0.04209583 0.0000000 0.07696667 0.07696667 0.00453364 0.00453364 TRUE TRUE
MSTRG.27894.7 ENSG00000158691 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN12 protein_coding   5.023592 1.219739 8.608007 0.1158096 0.3635364 2.809002 0.3227018 0.07036746 1.0451360 0.03542828 0.18195443 3.714674 0.05174583 0.0560000 0.12363333 0.06763333 0.48422365 0.00453364 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158691 E001 0.2966881 0.0290785164 1.000000e+00   6 28375993 28376022 30 - 0.110 0.001 -7.080
ENSG00000158691 E002 20.8049201 0.0010112702 4.142154e-09 5.476055e-08 6 28378955 28379218 264 - 1.101 1.578 1.666
ENSG00000158691 E003 80.1050676 0.0004004657 1.395803e-08 1.674990e-07 6 28379219 28380149 931 - 1.741 2.000 0.870
ENSG00000158691 E004 37.0265083 0.0006369890 7.782636e-01 8.573222e-01 6 28380150 28380337 188 - 1.473 1.505 0.111
ENSG00000158691 E005 34.8315873 0.0006010275 4.636938e-01 6.034703e-01 6 28380338 28380445 108 - 1.440 1.505 0.223
ENSG00000158691 E006 19.0884360 0.0009325656 3.100980e-01 4.524683e-01 6 28380446 28380488 43 - 1.182 1.289 0.377
ENSG00000158691 E007 22.6939566 0.0010278138 8.033977e-01 8.748558e-01 6 28380489 28380525 37 - 1.271 1.305 0.120
ENSG00000158691 E008 30.2873157 0.0022694821 7.177586e-01 8.130372e-01 6 28380526 28380614 89 - 1.387 1.428 0.143
ENSG00000158691 E009 30.5133159 0.0007214823 2.629375e-01 4.007685e-01 6 28380615 28380730 116 - 1.377 1.474 0.335
ENSG00000158691 E010 16.6331136 0.0010933799 9.969204e-01 1.000000e+00 6 28380731 28380758 28 - 1.144 1.155 0.041
ENSG00000158691 E011 29.5152731 0.0006891142 9.703294e-01 9.854247e-01 6 28380759 28380871 113 - 1.382 1.391 0.031
ENSG00000158691 E012 10.0100180 0.0092822974 5.088837e-01 6.442648e-01 6 28380872 28382190 1319 - 0.963 0.883 -0.303
ENSG00000158691 E013 68.8340878 0.0004937446 2.842445e-02 6.886625e-02 6 28382191 28382609 419 - 1.759 1.649 -0.373
ENSG00000158691 E014 23.3449376 0.0283814007 8.447620e-02 1.665643e-01 6 28384738 28386154 1417 - 1.240 1.440 0.697
ENSG00000158691 E015 15.7575554 0.0011569722 1.152954e-01 2.132820e-01 6 28386155 28386236 82 - 1.086 1.255 0.601
ENSG00000158691 E016 74.5309308 0.0362783978 2.070971e-01 3.350492e-01 6 28386237 28390417 4181 - 1.743 1.885 0.480
ENSG00000158691 E017 23.3365928 0.0066575342 1.085855e-01 2.034516e-01 6 28390418 28390595 178 - 1.312 1.155 -0.553
ENSG00000158691 E018 129.1229658 0.0003447067 7.256177e-10 1.104749e-08 6 28390596 28391742 1147 - 2.046 1.794 -0.847
ENSG00000158691 E019 28.4726808 0.0008119734 2.328754e-03 8.239793e-03 6 28392902 28393046 145 - 1.407 1.132 -0.968
ENSG00000158691 E020 50.0582197 0.0005212168 5.094962e-05 2.865786e-04 6 28398004 28398473 470 - 1.644 1.364 -0.959
ENSG00000158691 E021 18.4180403 0.0010211763 1.425051e-02 3.879405e-02 6 28399657 28399747 91 - 1.229 0.960 -0.972