ENSG00000158669

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396987 ENSG00000158669 HEK293_OSMI2_2hA HEK293_TMG_2hB GPAT4 protein_coding protein_coding 63.24347 58.70249 56.73163 4.35944 1.208411 -0.04925982 13.376042 17.15650 10.748757 0.8851655 0.5044087 -0.6740843 0.2146083 0.2963667 0.1893667 -0.1070 0.02626555 0.005659772 FALSE TRUE
ENST00000519921 ENSG00000158669 HEK293_OSMI2_2hA HEK293_TMG_2hB GPAT4 protein_coding retained_intron 63.24347 58.70249 56.73163 4.35944 1.208411 -0.04925982 5.575573 2.94710 4.659188 0.5134471 0.4494962 0.6589884 0.0864375 0.0505000 0.0819000 0.0314 0.14088653 0.005659772 FALSE FALSE
MSTRG.31440.8 ENSG00000158669 HEK293_OSMI2_2hA HEK293_TMG_2hB GPAT4 protein_coding   63.24347 58.70249 56.73163 4.35944 1.208411 -0.04925982 36.864901 31.29542 34.834144 4.1701334 0.6980406 0.1545036 0.5828833 0.5294667 0.6140667 0.0846 0.22723846 0.005659772 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158669 E001 0.000000       8 41577187 41577435 249 +      
ENSG00000158669 E002 1.543603 0.0089355405 2.646437e-01 4.026047e-01 8 41578114 41578166 53 + 0.513 0.327 -1.010
ENSG00000158669 E003 1.695118 0.0077732233 1.583645e-01 2.729460e-01 8 41578167 41578174 8 + 0.561 0.327 -1.232
ENSG00000158669 E004 5.261937 0.0032977725 5.523022e-03 1.734702e-02 8 41578175 41578187 13 + 0.968 0.612 -1.423
ENSG00000158669 E005 8.603997 0.0067852057 4.835367e-02 1.062526e-01 8 41578188 41578198 11 + 1.090 0.873 -0.805
ENSG00000158669 E006 11.911703 0.0225406827 6.239578e-02 1.306818e-01 8 41578199 41578199 1 + 1.216 1.002 -0.772
ENSG00000158669 E007 32.335591 0.0065104921 1.320218e-03 5.044500e-03 8 41578200 41578214 15 + 1.632 1.407 -0.769
ENSG00000158669 E008 144.142788 0.0058097452 4.104598e-03 1.343646e-02 8 41578215 41578278 64 + 2.224 2.096 -0.428
ENSG00000158669 E009 4.875671 0.0393314444 4.477825e-01 5.891331e-01 8 41578415 41578580 166 + 0.679 0.802 0.499
ENSG00000158669 E010 0.000000       8 41584772 41584772 1 +      
ENSG00000158669 E011 4.812714 0.0095451828 6.224946e-02 1.304215e-01 8 41584773 41584917 145 + 0.891 0.641 -1.008
ENSG00000158669 E012 6.718983 0.0145615460 6.961214e-01 7.965578e-01 8 41596748 41596878 131 + 0.912 0.871 -0.156
ENSG00000158669 E013 384.541526 0.0066214198 1.187886e-03 4.600288e-03 8 41598292 41598476 185 + 2.651 2.518 -0.440
ENSG00000158669 E014 788.422388 0.0025280511 4.475649e-05 2.551451e-04 8 41598477 41598925 449 + 2.945 2.844 -0.337
ENSG00000158669 E015 408.019167 0.0032587114 1.653129e-02 4.391075e-02 8 41598926 41599047 122 + 2.643 2.572 -0.236
ENSG00000158669 E016 507.156986 0.0008113890 5.459587e-03 1.718082e-02 8 41599048 41599233 186 + 2.725 2.675 -0.167
ENSG00000158669 E017 408.820315 0.0012240746 9.383347e-03 2.724113e-02 8 41599234 41599304 71 + 2.634 2.579 -0.186
ENSG00000158669 E018 438.828891 0.0007205001 5.130178e-02 1.114714e-01 8 41609416 41609485 70 + 2.652 2.619 -0.112
ENSG00000158669 E019 526.864298 0.0014056298 1.871674e-01 3.101825e-01 8 41609655 41609809 155 + 2.726 2.702 -0.079
ENSG00000158669 E020 402.333649 0.0012323587 7.003966e-01 7.998826e-01 8 41609810 41609880 71 + 2.595 2.592 -0.010
ENSG00000158669 E021 348.334962 0.0001486536 9.806396e-02 1.875724e-01 8 41609881 41609955 75 + 2.506 2.547 0.137
ENSG00000158669 E022 34.672608 0.0024986467 9.166608e-07 7.670773e-06 8 41610256 41610598 343 + 1.705 1.409 -1.013
ENSG00000158669 E023 15.558539 0.0357917512 3.734442e-02 8.611828e-02 8 41610599 41610621 23 + 1.345 1.115 -0.812
ENSG00000158669 E024 26.021173 0.0112676736 1.118389e-02 3.160528e-02 8 41610622 41610735 114 + 1.539 1.340 -0.686
ENSG00000158669 E025 297.746917 0.0002419860 3.630083e-01 5.074327e-01 8 41610736 41610777 42 + 2.446 2.474 0.093
ENSG00000158669 E026 291.471797 0.0001491228 3.467344e-01 4.908668e-01 8 41610778 41610810 33 + 2.438 2.466 0.095
ENSG00000158669 E027 2.269568 0.1327512325 5.914458e-03 1.838504e-02 8 41610811 41610812 2 + 0.770 0.194 -3.115
ENSG00000158669 E028 421.515039 0.0011536577 5.809839e-01 7.056124e-01 8 41611903 41611992 90 + 2.602 2.623 0.068
ENSG00000158669 E029 472.593184 0.0006090809 3.786557e-01 5.229719e-01 8 41612180 41612273 94 + 2.671 2.661 -0.034
ENSG00000158669 E030 3.896716 0.0300156218 1.082286e-01 2.029195e-01 8 41612786 41612844 59 + 0.823 0.579 -1.014
ENSG00000158669 E031 567.097001 0.0008616999 5.188257e-01 6.529791e-01 8 41612845 41612960 116 + 2.731 2.752 0.070
ENSG00000158669 E032 437.388341 0.0002166543 3.260668e-02 7.701281e-02 8 41614386 41614441 56 + 2.603 2.650 0.158
ENSG00000158669 E033 509.843469 0.0001197168 1.160118e-01 2.142573e-01 8 41614963 41615048 86 + 2.677 2.711 0.114
ENSG00000158669 E034 14.038851 0.0012899061 3.165195e-01 4.593031e-01 8 41618532 41618683 152 + 1.216 1.135 -0.290
ENSG00000158669 E035 367.297318 0.0001865689 3.610250e-01 5.053988e-01 8 41618684 41618705 22 + 2.539 2.566 0.087
ENSG00000158669 E036 585.983686 0.0003875684 1.339049e-01 2.395783e-01 8 41618706 41618812 107 + 2.736 2.770 0.111
ENSG00000158669 E037 1.326422 0.0102074342 3.162061e-01 4.589680e-01 8 41618813 41618813 1 + 0.244 0.429 1.160
ENSG00000158669 E038 284.075219 0.0001853576 8.682148e-01 9.192409e-01 8 41618898 41618901 4 + 2.442 2.446 0.016
ENSG00000158669 E039 507.351038 0.0004222384 2.714722e-02 6.629885e-02 8 41618902 41618977 76 + 2.665 2.714 0.163
ENSG00000158669 E040 6.801551 0.0487250352 7.356681e-02 1.492345e-01 8 41618978 41619220 243 + 1.034 0.759 -1.048
ENSG00000158669 E041 6.379681 0.0159486862 9.415967e-01 9.672860e-01 8 41619221 41619351 131 + 0.847 0.841 -0.022
ENSG00000158669 E042 4.863889 0.0036397732 2.227348e-01 3.536410e-01 8 41620794 41620892 99 + 0.643 0.821 0.728
ENSG00000158669 E043 2306.651254 0.0029014596 6.194345e-06 4.318943e-05 8 41620893 41625001 4109 + 3.280 3.390 0.364