ENSG00000158555

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336898 ENSG00000158555 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD5 protein_coding protein_coding 5.368428 7.47242 3.257688 0.198622 0.2908329 -1.195234 1.8766879 1.8290533 1.80659463 0.14067994 0.07079670 -0.01772676 0.37615833 0.24503333 0.56100000 0.31596667 2.747732e-06 1.589306e-13 FALSE TRUE
ENST00000526177 ENSG00000158555 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD5 protein_coding protein_coding 5.368428 7.47242 3.257688 0.198622 0.2908329 -1.195234 0.2834267 0.3669987 0.10189750 0.05854125 0.02086595 -1.75238182 0.05099167 0.04876667 0.03260000 -0.01616667 6.341888e-01 1.589306e-13 FALSE TRUE
ENST00000527820 ENSG00000158555 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD5 protein_coding nonsense_mediated_decay 5.368428 7.47242 3.257688 0.198622 0.2908329 -1.195234 0.1837230 0.2546833 0.28335400 0.11843292 0.02734268 0.14837529 0.03519167 0.03330000 0.08853333 0.05523333 1.474905e-01 1.589306e-13 FALSE TRUE
ENST00000529721 ENSG00000158555 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD5 protein_coding protein_coding 5.368428 7.47242 3.257688 0.198622 0.2908329 -1.195234 1.0138947 1.6400586 0.14624095 0.14593304 0.14624095 -3.40067268 0.17805417 0.22043333 0.04003333 -0.18040000 9.650088e-02 1.589306e-13 FALSE TRUE
ENST00000531561 ENSG00000158555 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD5 protein_coding retained_intron 5.368428 7.47242 3.257688 0.198622 0.2908329 -1.195234 0.3145422 0.3727860 0.07717083 0.20112191 0.07717083 -2.13462090 0.05595417 0.05133333 0.02113333 -0.03020000 7.218010e-01 1.589306e-13 FALSE FALSE
ENST00000532435 ENSG00000158555 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD5 protein_coding protein_coding 5.368428 7.47242 3.257688 0.198622 0.2908329 -1.195234 0.5207824 0.0000000 0.54357200 0.00000000 0.15414203 5.79069907 0.11212500 0.00000000 0.17073333 0.17073333 4.773150e-08 1.589306e-13 TRUE FALSE
ENST00000533784 ENSG00000158555 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD5 protein_coding protein_coding 5.368428 7.47242 3.257688 0.198622 0.2908329 -1.195234 0.4012148 1.6374646 0.00000000 0.15096909 0.00000000 -7.36410366 0.05845417 0.22016667 0.00000000 -0.22016667 1.589306e-13 1.589306e-13 FALSE TRUE
MSTRG.5998.8 ENSG00000158555 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD5 protein_coding   5.368428 7.47242 3.257688 0.198622 0.2908329 -1.195234 0.1465034 0.5775280 0.00000000 0.26714621 0.00000000 -5.87658565 0.02002083 0.07570000 0.00000000 -0.07570000 1.808456e-02 1.589306e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158555 E001 0.1472490 0.0419726129 1.775022e-01   11 75434640 75434640 1 - 0.182 0.000 -11.347
ENSG00000158555 E002 59.1043772 0.0204816072 1.086735e-02 0.0308497166 11 75434641 75434914 274 - 1.514 1.766 0.857
ENSG00000158555 E003 37.1422870 0.0138607014 3.664816e-03 0.0121956806 11 75434915 75434938 24 - 1.282 1.576 1.014
ENSG00000158555 E004 114.0017496 0.0111489082 4.149912e-04 0.0018318392 11 75434939 75435353 415 - 1.801 2.045 0.820
ENSG00000158555 E005 55.8364278 0.0004655172 2.378341e-03 0.0083936209 11 75435354 75435564 211 - 1.534 1.728 0.659
ENSG00000158555 E006 39.1164105 0.0087496770 7.782769e-02 0.1559909998 11 75435565 75435655 91 - 1.405 1.569 0.564
ENSG00000158555 E007 1.3682388 0.0096765512 8.916702e-01 0.9348014878 11 75435656 75435658 3 - 0.309 0.347 0.237
ENSG00000158555 E008 39.7668076 0.0162821881 4.705094e-01 0.6097394337 11 75436936 75437048 113 - 1.478 1.562 0.290
ENSG00000158555 E009 2.0218912 0.0071449405 3.955327e-01 0.5393387678 11 75437049 75438848 1800 - 0.309 0.483 0.974
ENSG00000158555 E010 0.0000000       11 75439340 75439354 15 -      
ENSG00000158555 E011 35.0266861 0.0006597884 2.202043e-01 0.3506754160 11 75439879 75439961 83 - 1.405 1.511 0.366
ENSG00000158555 E012 45.2662331 0.0031040502 5.770607e-01 0.7023740767 11 75441163 75441310 148 - 1.554 1.611 0.197
ENSG00000158555 E013 24.3089885 0.0008201576 4.391330e-01 0.5809105817 11 75441646 75441689 44 - 1.368 1.330 -0.130
ENSG00000158555 E014 36.6321957 0.0005951745 9.810083e-01 0.9921395193 11 75441690 75441803 114 - 1.493 1.514 0.071
ENSG00000158555 E015 47.9970686 0.0005192606 4.319135e-01 0.5744020632 11 75442363 75442581 219 - 1.566 1.634 0.232
ENSG00000158555 E016 1.2855349 0.0836682020 3.595266e-01 0.5038559290 11 75442582 75442697 116 - 0.182 0.382 1.440
ENSG00000158555 E017 2.0023139 0.0492650308 6.116628e-02 0.1285891903 11 75442764 75443062 299 - 0.666 0.345 -1.585
ENSG00000158555 E018 1.5187101 0.0096125491 2.731113e-01 0.4120912529 11 75443063 75443135 73 - 0.488 0.305 -1.025
ENSG00000158555 E019 40.9383005 0.0006847425 2.521322e-01 0.3884589741 11 75443136 75443286 151 - 1.584 1.538 -0.158
ENSG00000158555 E020 28.7617392 0.0109090972 7.225323e-01 0.8166135289 11 75444413 75444495 83 - 1.358 1.417 0.206
ENSG00000158555 E021 1.3285721 0.3291334284 9.334782e-01 0.9620794726 11 75448492 75448649 158 - 0.309 0.317 0.050
ENSG00000158555 E022 29.6720514 0.0114721213 6.278356e-01 0.7435279428 11 75448977 75449122 146 - 1.422 1.409 -0.045
ENSG00000158555 E023 24.0327087 0.0009225746 6.340795e-01 0.7486488685 11 75449517 75449610 94 - 1.338 1.322 -0.053
ENSG00000158555 E024 26.7641138 0.0009247282 9.207848e-01 0.9540368643 11 75449885 75449983 99 - 1.348 1.378 0.104
ENSG00000158555 E025 7.5082088 0.0023381723 9.344465e-02 0.1805027558 11 75450393 75451233 841 - 0.666 0.921 1.016
ENSG00000158555 E026 8.5469457 0.0087356058 9.520498e-02 0.1831858654 11 75451333 75452331 999 - 1.036 0.855 -0.681
ENSG00000158555 E027 3.3589735 0.0166292381 3.941558e-02 0.0899506495 11 75452816 75452970 155 - 0.792 0.484 -1.344
ENSG00000158555 E028 0.6277178 0.0191115729 4.982049e-02 0.1088407418 11 75455204 75455354 151 - 0.408 0.081 -2.932
ENSG00000158555 E029 0.4031496 0.0247020888 6.316352e-01 0.7466052000 11 75456542 75456756 215 - 0.000 0.149 11.934
ENSG00000158555 E030 22.9501256 0.0013682133 1.917005e-01 0.3158968693 11 75456757 75456816 60 - 1.368 1.287 -0.280
ENSG00000158555 E031 27.7406182 0.0007565894 9.994653e-04 0.0039562412 11 75457693 75457786 94 - 1.534 1.331 -0.703
ENSG00000158555 E032 29.7311019 0.0008017283 1.378702e-03 0.0052374359 11 75462786 75462889 104 - 1.560 1.370 -0.653
ENSG00000158555 E033 36.3847429 0.0006336859 5.369498e-05 0.0003001845 11 75477619 75477795 177 - 1.659 1.440 -0.751
ENSG00000158555 E034 0.1472490 0.0419726129 1.775022e-01   11 75477796 75477851 56 - 0.182 0.000 -13.935
ENSG00000158555 E035 18.6831840 0.0010345768 1.603129e-01 0.2755545016 11 75479244 75479488 245 - 1.294 1.196 -0.346
ENSG00000158555 E036 0.1515154 0.0423794837 1.768860e-01   11 75485305 75485741 437 - 0.182 0.000 -13.935
ENSG00000158555 E037 18.2423594 0.0010261498 2.206693e-02 0.0558203052 11 75490237 75490320 84 - 1.338 1.167 -0.602
ENSG00000158555 E038 0.0000000       11 75490604 75490751 148 -      
ENSG00000158555 E039 0.0000000       11 75492384 75492483 100 -      
ENSG00000158555 E040 0.5169874 0.0198784477 8.058465e-01 0.8765700505 11 75506653 75506825 173 - 0.182 0.149 -0.347
ENSG00000158555 E041 0.0000000       11 75508894 75508963 70 -      
ENSG00000158555 E042 0.0000000       11 75515975 75516092 118 -      
ENSG00000158555 E043 0.0000000       11 75516093 75516166 74 -      
ENSG00000158555 E044 0.1482932 0.0414611313 1.000000e+00   11 75517329 75517426 98 - 0.000 0.080 10.946
ENSG00000158555 E045 15.9726065 0.0057374700 1.416260e-02 0.0385940908 11 75525210 75525283 74 - 1.305 1.096 -0.742
ENSG00000158555 E046 25.2391792 0.0008589472 2.293352e-05 0.0001402145 11 75525284 75525573 290 - 1.541 1.264 -0.959
ENSG00000158555 E047 11.1695059 0.0016501243 7.696887e-05 0.0004137306 11 75525574 75525788 215 - 1.271 0.900 -1.347
ENSG00000158555 E048 5.6381278 0.0049119278 1.090158e-02 0.0309251111 11 75525789 75525941 153 - 0.969 0.651 -1.257