ENSG00000158552

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289528 ENSG00000158552 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND2B protein_coding protein_coding 26.52494 45.0321 13.42548 1.315497 0.180874 -1.745226 2.218469 5.058864 0.1092657 1.2216332 0.10926574 -5.40941081 0.05994167 0.11350000 0.007933333 -0.10556667 2.029134e-02 4.067504e-06 FALSE TRUE
ENST00000409336 ENSG00000158552 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND2B protein_coding protein_coding 26.52494 45.0321 13.42548 1.315497 0.180874 -1.745226 1.504311 2.450508 1.2547864 1.4447460 0.90008019 -0.96006242 0.06457500 0.05510000 0.091966667 0.03686667 9.745454e-01 4.067504e-06 FALSE TRUE
ENST00000409594 ENSG00000158552 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND2B protein_coding protein_coding 26.52494 45.0321 13.42548 1.315497 0.180874 -1.745226 1.916592 1.277638 1.3130487 0.2526974 0.14536687 0.03913864 0.09247917 0.02826667 0.097533333 0.06926667 1.088452e-04 4.067504e-06 FALSE TRUE
ENST00000444522 ENSG00000158552 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND2B protein_coding protein_coding 26.52494 45.0321 13.42548 1.315497 0.180874 -1.745226 14.868885 27.417680 6.4875175 2.4004149 0.55034054 -2.07767209 0.52421250 0.60693333 0.484200000 -0.12273333 2.763174e-01 4.067504e-06 FALSE TRUE
ENST00000489197 ENSG00000158552 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND2B protein_coding retained_intron 26.52494 45.0321 13.42548 1.315497 0.180874 -1.745226 1.315811 1.008729 1.1093169 0.1896439 0.05645686 0.13584836 0.06307500 0.02253333 0.082666667 0.06013333 4.067504e-06 4.067504e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158552 E001 0.0000000       2 219195237 219195369 133 +      
ENSG00000158552 E002 0.3697384 0.0274424043 1.000000e+00 1.000000e+00 2 219200432 219200642 211 + 0.001 0.125 8.029
ENSG00000158552 E003 0.0000000       2 219203793 219204018 226 +      
ENSG00000158552 E004 0.2214452 0.0388150080 1.000000e+00   2 219206782 219206783 2 + 0.000 0.067 8.949
ENSG00000158552 E005 1.0600242 0.0224595430 8.118275e-01 8.806086e-01 2 219206784 219206792 9 + 0.214 0.263 0.385
ENSG00000158552 E006 3.3818112 0.0050892946 9.697235e-01 9.850444e-01 2 219206793 219206803 11 + 0.550 0.544 -0.030
ENSG00000158552 E007 7.9259595 0.0300075509 3.106456e-01 4.530650e-01 2 219206804 219206806 3 + 0.967 0.814 -0.585
ENSG00000158552 E008 10.1358846 0.0050741815 3.988452e-01 5.425902e-01 2 219206807 219206808 2 + 1.023 0.920 -0.385
ENSG00000158552 E009 14.0786748 0.0056759038 8.755096e-01 9.240363e-01 2 219206809 219206811 3 + 1.049 1.067 0.065
ENSG00000158552 E010 16.6606288 0.0036518003 7.123945e-01 8.091524e-01 2 219206812 219206814 3 + 1.096 1.136 0.143
ENSG00000158552 E011 41.2149317 0.0224315799 3.278775e-01 4.713488e-01 2 219206815 219206845 31 + 1.423 1.522 0.343
ENSG00000158552 E012 0.0000000       2 219206846 219206847 2 +      
ENSG00000158552 E013 0.1482932 0.0414550397 1.000000e+00   2 219206848 219206874 27 + 0.000 0.067 8.922
ENSG00000158552 E014 1.3953073 0.0098806681 7.702277e-01 8.516197e-01 2 219206875 219206879 5 + 0.357 0.301 -0.353
ENSG00000158552 E015 1.9897131 0.0077344545 6.061809e-01 7.263945e-01 2 219206880 219206881 2 + 0.464 0.368 -0.521
ENSG00000158552 E016 30.0546120 0.0201658954 8.725615e-01 9.220344e-01 2 219206882 219206966 85 + 1.367 1.383 0.054
ENSG00000158552 E017 28.5811962 0.0028913529 7.860842e-01 8.630053e-01 2 219206967 219206969 3 + 1.379 1.357 -0.076
ENSG00000158552 E018 110.3112886 0.0103777300 8.791305e-01 9.263768e-01 2 219206970 219207042 73 + 1.923 1.930 0.025
ENSG00000158552 E019 1.5113482 0.0104826178 3.824754e-01 5.266745e-01 2 219207085 219207217 133 + 0.464 0.300 -0.939
ENSG00000158552 E020 2.7291924 0.0057460556 4.018476e-02 9.137797e-02 2 219207218 219207262 45 + 0.737 0.397 -1.575
ENSG00000158552 E021 7.4623923 0.0083278774 4.022027e-02 9.143898e-02 2 219207263 219207326 64 + 1.023 0.754 -1.033
ENSG00000158552 E022 162.0191400 0.0058781092 9.252604e-01 9.569523e-01 2 219207327 219207421 95 + 2.091 2.095 0.014
ENSG00000158552 E023 11.0441297 0.0285370917 2.035425e-06 1.580997e-05 2 219207422 219207647 226 + 1.379 0.792 -2.143
ENSG00000158552 E024 197.8625973 0.0002341813 8.699139e-01 9.203167e-01 2 219207648 219207774 127 + 2.175 2.180 0.020
ENSG00000158552 E025 100.1962150 0.0003012628 3.516132e-01 4.958538e-01 2 219207775 219207779 5 + 1.920 1.881 -0.133
ENSG00000158552 E026 8.4293846 0.0033380570 7.644271e-03 2.288462e-02 2 219207780 219207886 107 + 1.117 0.800 -1.187
ENSG00000158552 E027 284.3368412 0.0001818726 8.767516e-01 9.248937e-01 2 219207887 219208038 152 + 2.333 2.337 0.016
ENSG00000158552 E028 4.1747650 0.0039484397 1.058982e-03 4.162950e-03 2 219208039 219208255 217 + 0.968 0.500 -1.940
ENSG00000158552 E029 243.5419872 0.0001982984 4.210554e-01 5.642036e-01 2 219208256 219208348 93 + 2.251 2.274 0.078
ENSG00000158552 E030 17.0458116 0.0011328514 2.540579e-06 1.932642e-05 2 219208349 219208425 77 + 1.443 1.034 -1.448
ENSG00000158552 E031 196.6075873 0.0002312733 3.564178e-01 5.007956e-01 2 219208426 219208457 32 + 2.152 2.182 0.101
ENSG00000158552 E032 170.9281345 0.0002086283 5.272870e-02 1.140070e-01 2 219208458 219208486 29 + 2.061 2.129 0.227
ENSG00000158552 E033 6.8277841 0.0025128600 2.843876e-04 1.316402e-03 2 219208487 219208571 85 + 1.117 0.668 -1.727
ENSG00000158552 E034 216.7960892 0.0023836583 3.673433e-02 8.496269e-02 2 219208572 219208639 68 + 2.154 2.236 0.273
ENSG00000158552 E035 36.4415585 0.0060934338 3.734238e-07 3.387475e-06 2 219208640 219208976 337 + 1.726 1.368 -1.228
ENSG00000158552 E036 229.2210337 0.0056373132 3.863180e-01 5.305121e-01 2 219208977 219209049 73 + 2.212 2.255 0.143
ENSG00000158552 E037 28.6053628 0.0217772020 8.397415e-06 5.677200e-05 2 219209050 219209261 212 + 1.671 1.248 -1.456
ENSG00000158552 E038 320.6840114 0.0012078897 1.355591e-02 3.720520e-02 2 219209262 219209651 390 + 2.331 2.404 0.243