ENSG00000158473

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368171 ENSG00000158473 HEK293_OSMI2_2hA HEK293_TMG_2hB CD1D protein_coding protein_coding 0.1352647 0.1211939 0.1683839 0.03719339 0.009790834 0.443285 0.031904195 0.003915021 0.06094382 0.003915021 0.06094382 2.350034 0.24655000 0.07636667 0.3333333 0.2569667 0.95889986 0.00774524 FALSE TRUE
ENST00000673623 ENSG00000158473 HEK293_OSMI2_2hA HEK293_TMG_2hB CD1D protein_coding protein_coding 0.1352647 0.1211939 0.1683839 0.03719339 0.009790834 0.443285 0.004348119 0.010884133 0.00000000 0.010884133 0.00000000 -1.062407 0.05570833 0.08110000 0.0000000 -0.0811000 0.71186228 0.00774524 FALSE TRUE
ENST00000673701 ENSG00000158473 HEK293_OSMI2_2hA HEK293_TMG_2hB CD1D protein_coding protein_coding 0.1352647 0.1211939 0.1683839 0.03719339 0.009790834 0.443285 0.031040399 0.078510322 0.00000000 0.040356696 0.00000000 -3.145846 0.25090000 0.50296667 0.0000000 -0.5029667 0.00774524 0.00774524 FALSE TRUE
ENST00000673723 ENSG00000158473 HEK293_OSMI2_2hA HEK293_TMG_2hB CD1D protein_coding protein_coding 0.1352647 0.1211939 0.1683839 0.03719339 0.009790834 0.443285 0.007191964 0.000000000 0.05753571 0.000000000 0.05753571 2.755651 0.04166667 0.00000000 0.3333333 0.3333333 0.95892058 0.00774524 FALSE TRUE
ENST00000674023 ENSG00000158473 HEK293_OSMI2_2hA HEK293_TMG_2hB CD1D protein_coding retained_intron 0.1352647 0.1211939 0.1683839 0.03719339 0.009790834 0.443285 0.010785613 0.014711769 0.00000000 0.014711769 0.00000000 -1.305198 0.04531250 0.08260000 0.0000000 -0.0826000 0.55750677 0.00774524 FALSE TRUE
ENST00000674047 ENSG00000158473 HEK293_OSMI2_2hA HEK293_TMG_2hB CD1D protein_coding retained_intron 0.1352647 0.1211939 0.1683839 0.03719339 0.009790834 0.443285 0.012233842 0.013172666 0.00000000 0.013172666 0.00000000 -1.212424 0.07426667 0.25696667 0.0000000 -0.2569667 0.83981640 0.00774524 FALSE TRUE
ENST00000674085 ENSG00000158473 HEK293_OSMI2_2hA HEK293_TMG_2hB CD1D protein_coding protein_coding 0.1352647 0.1211939 0.1683839 0.03719339 0.009790834 0.443285 0.037760544 0.000000000 0.04990440 0.000000000 0.04990440 2.582662 0.28560000 0.00000000 0.3333333 0.3333333 0.96640902 0.00774524 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158473 E001 0.1472490 0.050997817 1.00000000   1 158178030 158178068 39 + 0.095 0.000 -8.763
ENSG00000158473 E002 0.0000000       1 158179947 158180162 216 +      
ENSG00000158473 E003 0.6717251 0.022882463 0.73039490 0.82236004 1 158180819 158180888 70 + 0.239 0.157 -0.756
ENSG00000158473 E004 0.6717251 0.022882463 0.73039490 0.82236004 1 158180889 158180894 6 + 0.239 0.157 -0.756
ENSG00000158473 E005 1.5594976 0.010515761 0.74313930 0.83187884 1 158180895 158181035 141 + 0.433 0.362 -0.396
ENSG00000158473 E006 0.8908930 0.019570189 0.45192660 0.59283976 1 158181036 158181050 15 + 0.239 0.361 0.822
ENSG00000158473 E007 1.3306775 0.017123331 0.90988202 0.94672410 1 158181051 158181162 112 + 0.392 0.361 -0.177
ENSG00000158473 E008 0.8815316 0.017546985 0.04993747 0.10905856 1 158181455 158181489 35 + 0.392 0.000 -12.168
ENSG00000158473 E009 1.9564208 0.009377607 0.10500124 0.19809959 1 158181490 158181721 232 + 0.567 0.271 -1.633
ENSG00000158473 E010 2.6227586 0.007243862 0.96989094 0.98516395 1 158182032 158182310 279 + 0.567 0.556 -0.049
ENSG00000158473 E011 0.2214452 0.520680307 0.27237841   1 158182311 158182525 215 + 0.000 0.161 10.673
ENSG00000158473 E012 0.3729606 0.034886245 0.61765472 0.73542099 1 158182526 158182846 321 + 0.095 0.157 0.831
ENSG00000158473 E013 2.6195244 0.006769522 0.61621954 0.73432138 1 158182878 158183156 279 + 0.595 0.501 -0.436
ENSG00000158473 E014 1.2512830 0.012768124 0.54931443 0.67905573 1 158183936 158184035 100 + 0.392 0.271 -0.757
ENSG00000158473 E015 5.2721667 0.004218942 0.01355531 0.03720465 1 158184129 158186427 2299 + 0.691 0.944 0.994