ENSG00000158470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371711 ENSG00000158470 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALT5 protein_coding protein_coding 27.44877 18.97008 32.66078 1.539868 0.1782759 0.783515 23.416820 18.91145 24.727820 1.559431 0.4450527 0.386696 0.87931250 0.9966667 0.7570333 -0.2396333 1.601182e-46 1.601182e-46 FALSE TRUE
MSTRG.20826.1 ENSG00000158470 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALT5 protein_coding   27.44877 18.97008 32.66078 1.539868 0.1782759 0.783515 1.159751 0.00000 3.830717 0.000000 1.0558520 8.585232 0.03466667 0.0000000 0.1172333 0.1172333 3.892667e-11 1.601182e-46 TRUE TRUE
MSTRG.20826.5 ENSG00000158470 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALT5 protein_coding   27.44877 18.97008 32.66078 1.539868 0.1782759 0.783515 2.724985 0.00000 3.987811 0.000000 0.8518726 8.643067 0.08079583 0.0000000 0.1222000 0.1222000 5.535665e-15 1.601182e-46 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158470 E001 0.5932625 0.1637988993 1.101039e-01 2.056842e-01 20 49632065 49632105 41 - 0.292 0.000 -10.364
ENSG00000158470 E002 1826.3162779 0.0050327912 1.952099e-18 1.037070e-16 20 49632945 49635826 2882 - 3.112 3.406 0.980
ENSG00000158470 E003 194.0168861 0.0003987626 1.272788e-04 6.468745e-04 20 49635827 49635980 154 - 2.275 2.295 0.066
ENSG00000158470 E004 118.9190786 0.0010245008 1.264038e-04 6.430219e-04 20 49635981 49635995 15 - 2.079 2.064 -0.050
ENSG00000158470 E005 195.1418774 0.0002547760 2.171474e-05 1.334910e-04 20 49635996 49636086 91 - 2.281 2.293 0.039
ENSG00000158470 E006 391.9388752 0.0017714517 3.024681e-04 1.389569e-03 20 49636087 49636459 373 - 2.576 2.600 0.082
ENSG00000158470 E007 183.1107590 0.0022449936 3.142936e-03 1.068593e-02 20 49637341 49637442 102 - 2.250 2.266 0.055
ENSG00000158470 E008 217.5599507 0.0002593827 3.655004e-09 4.880044e-08 20 49639678 49639800 123 - 2.341 2.317 -0.082
ENSG00000158470 E009 231.0496613 0.0028738154 2.494079e-08 2.853407e-07 20 49640478 49640665 188 - 2.384 2.311 -0.246
ENSG00000158470 E010 153.7378294 0.0017640205 8.376126e-07 7.073650e-06 20 49642468 49642584 117 - 2.201 2.148 -0.177
ENSG00000158470 E011 182.0803507 0.0028915694 1.665475e-09 2.368230e-08 20 49643526 49643650 125 - 2.292 2.188 -0.349
ENSG00000158470 E012 157.6372229 0.0055915100 1.669080e-04 8.218807e-04 20 49646965 49647078 114 - 2.212 2.157 -0.185
ENSG00000158470 E013 1.3244220 0.0400059815 3.588813e-01 5.032493e-01 20 49649497 49649576 80 - 0.386 0.277 -0.686
ENSG00000158470 E014 127.3769358 0.0009656041 1.306265e-08 1.576330e-07 20 49656568 49656702 135 - 2.130 2.053 -0.258
ENSG00000158470 E015 0.6203429 0.0372254592 7.451044e-01 8.332515e-01 20 49679409 49679467 59 - 0.170 0.275 0.888
ENSG00000158470 E016 65.8717966 0.0003475301 1.093307e-20 7.612045e-19 20 49713576 49713904 329 - 1.919 1.597 -1.089