ENSG00000158411

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289359 ENSG00000158411 HEK293_OSMI2_2hA HEK293_TMG_2hB MITD1 protein_coding protein_coding 19.08794 11.47148 26.98336 1.54062 0.2779498 1.233296 11.386520 7.6371803 17.9686872 1.03499584 0.9394528 1.2332879 0.58987500 0.66550000 0.66596667 0.0004666667 1.00000000 0.005065687 FALSE  
ENST00000413710 ENSG00000158411 HEK293_OSMI2_2hA HEK293_TMG_2hB MITD1 protein_coding nonsense_mediated_decay 19.08794 11.47148 26.98336 1.54062 0.2779498 1.233296 1.017346 1.1476495 1.2708341 0.14622261 0.1459873 0.1458851 0.07014583 0.10243333 0.04723333 -0.0552000000 0.01479038 0.005065687 TRUE  
ENST00000464685 ENSG00000158411 HEK293_OSMI2_2hA HEK293_TMG_2hB MITD1 protein_coding retained_intron 19.08794 11.47148 26.98336 1.54062 0.2779498 1.233296 2.064996 0.7420786 2.3923271 0.09501721 0.1785209 1.6754772 0.10410417 0.06490000 0.08880000 0.0239000000 0.31428530 0.005065687 TRUE  
ENST00000483721 ENSG00000158411 HEK293_OSMI2_2hA HEK293_TMG_2hB MITD1 protein_coding retained_intron 19.08794 11.47148 26.98336 1.54062 0.2779498 1.233296 1.025907 0.6096032 0.8111368 0.33307642 0.1967908 0.4062779 0.05420417 0.04740000 0.02996667 -0.0174333333 0.99123504 0.005065687    
ENST00000487588 ENSG00000158411 HEK293_OSMI2_2hA HEK293_TMG_2hB MITD1 protein_coding processed_transcript 19.08794 11.47148 26.98336 1.54062 0.2779498 1.233296 1.174218 0.2008764 0.9087656 0.20087641 0.4570202 2.1232991 0.05282917 0.02203333 0.03370000 0.0116666667 0.68542417 0.005065687 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158411 E001 0.5911862 0.0183867459 1.390062e-01 2.467238e-01 2 99161159 99161351 193 - 0.291 0.000 -10.981
ENSG00000158411 E002 0.2966881 0.0273362088 4.528379e-01   2 99161352 99161426 75 - 0.169 0.000 -10.437
ENSG00000158411 E003 12.0248929 0.0015037932 7.756129e-01 8.554518e-01 2 99161427 99161668 242 - 1.103 1.128 0.089
ENSG00000158411 E004 1.1008118 0.0128999943 6.593685e-01 7.681948e-01 2 99161947 99162218 272 - 0.291 0.368 0.482
ENSG00000158411 E005 7.4083543 0.0058024169 4.975419e-01 6.340880e-01 2 99167649 99167847 199 - 0.948 0.859 -0.339
ENSG00000158411 E006 0.4448795 0.2172939029 5.604713e-02 1.197847e-01 2 99169263 99169265 3 - 0.000 0.360 12.140
ENSG00000158411 E007 22.1234592 0.0008672544 4.046930e-03 1.327283e-02 2 99169266 99169371 106 - 1.271 1.475 0.709
ENSG00000158411 E008 67.3014120 0.0004309088 3.127016e-02 7.442819e-02 2 99169372 99169444 73 - 1.794 1.883 0.300
ENSG00000158411 E009 64.5155832 0.0004757108 3.477412e-03 1.165950e-02 2 99169445 99169470 26 - 1.762 1.886 0.418
ENSG00000158411 E010 20.6153263 0.0033634770 2.805363e-06 2.113948e-05 2 99169471 99169549 79 - 1.157 1.522 1.273
ENSG00000158411 E011 112.8182935 0.0005322199 3.629083e-02 8.413927e-02 2 99169550 99169610 61 - 2.023 2.090 0.224
ENSG00000158411 E012 0.2998086 0.0279744678 6.449641e-01   2 99170535 99170536 2 - 0.093 0.159 0.895
ENSG00000158411 E013 158.2452047 0.0002119028 3.202207e-01 4.633203e-01 2 99170537 99170652 116 - 2.187 2.211 0.080
ENSG00000158411 E014 7.1837730 0.0075418043 8.614097e-01 9.145967e-01 2 99170653 99170905 253 - 0.911 0.885 -0.101
ENSG00000158411 E015 116.0254306 0.0002669921 9.787400e-01 9.908001e-01 2 99171343 99171429 87 - 2.063 2.061 -0.008
ENSG00000158411 E016 8.1816727 0.0136433205 4.433958e-01 5.849786e-01 2 99171430 99171509 80 - 0.924 1.012 0.328
ENSG00000158411 E017 146.6472614 0.0002336699 5.835236e-01 7.076218e-01 2 99171510 99171646 137 - 2.158 2.170 0.041
ENSG00000158411 E018 79.6643164 0.0005048233 1.666919e-04 8.209660e-04 2 99171647 99173346 1700 - 1.954 1.794 -0.538
ENSG00000158411 E019 12.1168057 0.0016350741 2.222680e-03 7.913701e-03 2 99173347 99173413 67 - 1.211 0.884 -1.196
ENSG00000158411 E020 20.2451984 0.0011697202 6.585922e-03 2.014960e-02 2 99173414 99173502 89 - 1.395 1.169 -0.793
ENSG00000158411 E021 25.8863486 0.0051930312 1.258545e-08 1.523401e-07 2 99173503 99173914 412 - 1.557 1.050 -1.779
ENSG00000158411 E022 110.0588896 0.0031249515 1.719040e-01 2.906839e-01 2 99173915 99174016 102 - 2.062 2.000 -0.209
ENSG00000158411 E023 0.5244761 0.2676027426 1.000000e+00 1.000000e+00 2 99178290 99178335 46 - 0.170 0.162 -0.082
ENSG00000158411 E024 2.8680275 0.0080283018 6.990382e-02 1.432225e-01 2 99180707 99180830 124 - 0.683 0.368 -1.518
ENSG00000158411 E025 98.9984654 0.0039835578 2.829066e-01 4.229701e-01 2 99180831 99181058 228 - 2.013 1.953 -0.201