ENSG00000158402

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323760 ENSG00000158402 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC25C protein_coding protein_coding 14.5116 11.62041 16.45544 2.282969 0.2879418 0.5015383 6.8604398 6.5685746 6.092352 1.37158876 0.2439728 -0.1084097 0.48843333 0.5614000 0.37086667 -0.19053333 0.004480084 0.004480084 FALSE TRUE
ENST00000415130 ENSG00000158402 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC25C protein_coding protein_coding 14.5116 11.62041 16.45544 2.282969 0.2879418 0.5015383 2.0823918 1.0930235 1.255753 0.06117792 0.6898673 0.1985320 0.14832500 0.1011000 0.07766667 -0.02343333 0.795442438 0.004480084 FALSE TRUE
ENST00000503022 ENSG00000158402 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC25C protein_coding protein_coding 14.5116 11.62041 16.45544 2.282969 0.2879418 0.5015383 2.1890311 0.5036436 4.609751 0.50364361 0.3394953 3.1689756 0.13237917 0.0443000 0.27956667 0.23526667 0.071535834 0.004480084 FALSE FALSE
MSTRG.26994.2 ENSG00000158402 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC25C protein_coding   14.5116 11.62041 16.45544 2.282969 0.2879418 0.5015383 0.7054808 1.8500735 0.000000 0.94184646 0.0000000 -7.5392158 0.05765833 0.1709333 0.00000000 -0.17093333 0.128903626 0.004480084 FALSE TRUE
MSTRG.26994.3 ENSG00000158402 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC25C protein_coding   14.5116 11.62041 16.45544 2.282969 0.2879418 0.5015383 1.7740906 1.0666386 2.741562 0.61491935 0.9770531 1.3537171 0.11176667 0.0766000 0.16460000 0.08800000 0.660912467 0.004480084 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158402 E001 25.5575451 0.0008055389 4.525813e-05 2.577411e-04 5 138285269 138285354 86 - 1.251 1.535 0.987
ENSG00000158402 E002 87.9800800 0.0003946786 9.905927e-07 8.225141e-06 5 138285355 138285572 218 - 1.847 2.030 0.617
ENSG00000158402 E003 38.6555007 0.0005636046 5.061736e-02 1.102549e-01 5 138285573 138285576 4 - 1.543 1.651 0.367
ENSG00000158402 E004 38.8352305 0.0005567102 7.852484e-02 1.571204e-01 5 138285577 138285579 3 - 1.552 1.648 0.328
ENSG00000158402 E005 89.0292799 0.0003505036 5.595671e-03 1.754349e-02 5 138285580 138285691 112 - 1.901 2.001 0.338
ENSG00000158402 E006 71.5282300 0.0003698406 8.648952e-03 2.540653e-02 5 138285692 138285743 52 - 1.805 1.911 0.359
ENSG00000158402 E007 89.8239278 0.0003539151 3.205711e-01 4.637134e-01 5 138285744 138285841 98 - 1.945 1.979 0.115
ENSG00000158402 E008 90.5151661 0.0004153169 1.096831e-01 2.050963e-01 5 138286022 138286133 112 - 1.936 1.993 0.190
ENSG00000158402 E009 97.3493628 0.0003540284 2.248568e-01 3.562637e-01 5 138286497 138286630 134 - 1.978 2.018 0.136
ENSG00000158402 E010 85.6804602 0.0003156158 6.559091e-01 7.657068e-01 5 138287169 138287267 99 - 1.955 1.937 -0.062
ENSG00000158402 E011 2.4034664 0.0059637709 7.525902e-05 4.054830e-04 5 138289480 138289500 21 - 0.788 0.117 -4.058
ENSG00000158402 E012 67.6811701 0.0004133457 4.134330e-01 5.569205e-01 5 138289501 138289563 63 - 1.865 1.830 -0.120
ENSG00000158402 E013 71.1304509 0.0003652087 1.125673e-01 2.093038e-01 5 138290639 138290740 102 - 1.901 1.834 -0.224
ENSG00000158402 E014 33.5740309 0.0006659700 9.784516e-01 9.906499e-01 5 138291970 138291984 15 - 1.543 1.539 -0.014
ENSG00000158402 E015 82.8343164 0.0003351911 4.558274e-02 1.012631e-01 5 138291985 138292116 132 - 1.973 1.896 -0.258
ENSG00000158402 E016 0.1482932 0.0411597534 5.158552e-01   5 138303547 138303682 136 - 0.000 0.117 9.508
ENSG00000158402 E017 0.1451727 0.0445095218 4.735151e-01   5 138316932 138317086 155 - 0.128 0.000 -10.089
ENSG00000158402 E018 107.6685509 0.0002837083 8.900921e-05 4.703503e-04 5 138319219 138319374 156 - 2.113 1.982 -0.438
ENSG00000158402 E019 75.3884913 0.0003834131 4.340314e-02 9.730075e-02 5 138325815 138325904 90 - 1.935 1.853 -0.275
ENSG00000158402 E020 4.0211758 0.0039130970 1.554144e-01 2.689502e-01 5 138325918 138326020 103 - 0.812 0.611 -0.831
ENSG00000158402 E021 56.6956744 0.0004543125 1.341189e-01 2.398832e-01 5 138326021 138326054 34 - 1.809 1.740 -0.234
ENSG00000158402 E022 72.8362600 0.0023231227 1.959700e-01 3.211701e-01 5 138328484 138328529 46 - 1.910 1.851 -0.198
ENSG00000158402 E023 1.5844897 0.0087668676 1.573411e-01 2.715651e-01 5 138328530 138328882 353 - 0.532 0.285 -1.373
ENSG00000158402 E024 74.6742794 0.0004269229 7.458290e-01 8.337481e-01 5 138329553 138329647 95 - 1.891 1.875 -0.053
ENSG00000158402 E025 138.8204999 0.0003023048 7.010798e-01 8.003928e-01 5 138330987 138331214 228 - 2.158 2.144 -0.047
ENSG00000158402 E026 19.7612518 0.0375333086 6.630713e-01 7.712186e-01 5 138331215 138331218 4 - 1.348 1.307 -0.143
ENSG00000158402 E027 103.4921594 0.0035625493 2.429330e-02 6.041974e-02 5 138331595 138331872 278 - 2.081 1.973 -0.360
ENSG00000158402 E028 2.5828884 0.0059433264 7.699420e-01 8.514622e-01 5 138337956 138338355 400 - 0.532 0.577 0.210