ENSG00000158122

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375234 ENSG00000158122 HEK293_OSMI2_2hA HEK293_TMG_2hB PRXL2C protein_coding protein_coding 4.311985 3.485333 6.400608 0.5507847 0.1988778 0.8750315 2.8544701 2.23187744 4.8439917 0.43377250 0.28724593 1.1144642 0.66763333 0.640966667 0.75553333 0.1145667 3.921925e-01 3.627913e-25 FALSE TRUE
ENST00000411939 ENSG00000158122 HEK293_OSMI2_2hA HEK293_TMG_2hB PRXL2C protein_coding protein_coding 4.311985 3.485333 6.400608 0.5507847 0.1988778 0.8750315 0.5502656 0.97539677 0.0000000 0.18250899 0.00000000 -6.6226328 0.15939583 0.277366667 0.00000000 -0.2773667 3.627913e-25 3.627913e-25 FALSE FALSE
ENST00000446045 ENSG00000158122 HEK293_OSMI2_2hA HEK293_TMG_2hB PRXL2C protein_coding protein_coding 4.311985 3.485333 6.400608 0.5507847 0.1988778 0.8750315 0.3042772 0.23572055 0.1737724 0.23572055 0.12276447 -0.4190985 0.06107500 0.072333333 0.02843333 -0.0439000 9.051977e-01 3.627913e-25 FALSE TRUE
MSTRG.33072.1 ENSG00000158122 HEK293_OSMI2_2hA HEK293_TMG_2hB PRXL2C protein_coding   4.311985 3.485333 6.400608 0.5507847 0.1988778 0.8750315 0.5259830 0.04233796 1.3828443 0.04233796 0.07538153 4.7340324 0.09865417 0.009333333 0.21603333 0.2067000 3.432177e-11 3.627913e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158122 E001 279.79215 0.0002394185 3.876624e-19 2.244544e-17 9 96639577 96641886 2310 - 2.386 2.519 0.442
ENSG00000158122 E002 60.82109 0.0004154594 5.089851e-01 6.443543e-01 9 96645893 96645989 97 - 1.777 1.800 0.078
ENSG00000158122 E003 33.28817 0.0006513264 5.044832e-01 6.403926e-01 9 96645990 96646024 35 - 1.515 1.549 0.117
ENSG00000158122 E004 72.01553 0.0004749166 1.862062e-02 4.849897e-02 9 96651390 96651495 106 - 1.897 1.794 -0.346
ENSG00000158122 E005 49.53219 0.0005576923 2.746603e-03 9.511841e-03 9 96651659 96651712 54 - 1.754 1.595 -0.539
ENSG00000158122 E006 41.77009 0.0005424425 3.214694e-05 1.898127e-04 9 96654705 96654773 69 - 1.707 1.465 -0.825
ENSG00000158122 E007 0.00000       9 96654774 96654972 199 -      
ENSG00000158122 E008 30.06374 0.0057025118 6.029723e-09 7.757116e-08 9 96655090 96655251 162 - 1.621 1.138 -1.679
ENSG00000158122 E009 10.93293 0.0274371829 4.185527e-10 6.647682e-09 9 96655252 96655353 102 - 1.267 0.159 -5.310