ENSG00000158106

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000289013 ENSG00000158106 HEK293_OSMI2_2hA HEK293_TMG_2hB RHPN1 protein_coding protein_coding 6.245791 8.302005 3.423806 0.96426 0.08047293 -1.275388 0.2777540 0.8016727 0.0000000 0.40937062 0.00000000 -6.3428262 0.03709167 0.09820000 0.00000000 -0.09820000 2.931088e-01 2.990074e-15 FALSE TRUE
ENST00000522335 ENSG00000158106 HEK293_OSMI2_2hA HEK293_TMG_2hB RHPN1 protein_coding retained_intron 6.245791 8.302005 3.423806 0.96426 0.08047293 -1.275388 0.8839455 0.6648581 0.4506276 0.08647590 0.07554930 -0.5509832 0.14918333 0.08276667 0.13250000 0.04973333 4.084653e-01 2.990074e-15 TRUE TRUE
ENST00000522899 ENSG00000158106 HEK293_OSMI2_2hA HEK293_TMG_2hB RHPN1 protein_coding retained_intron 6.245791 8.302005 3.423806 0.96426 0.08047293 -1.275388 0.8029217 1.2591706 0.2303860 0.04730026 0.23038604 -2.4004609 0.11164583 0.15673333 0.06476667 -0.09196667 2.549525e-01 2.990074e-15 FALSE TRUE
MSTRG.32197.1 ENSG00000158106 HEK293_OSMI2_2hA HEK293_TMG_2hB RHPN1 protein_coding   6.245791 8.302005 3.423806 0.96426 0.08047293 -1.275388 0.3506844 0.3015671 0.5640628 0.18519010 0.08116863 0.8816657 0.06413750 0.04040000 0.16390000 0.12350000 1.787305e-01 2.990074e-15 FALSE TRUE
MSTRG.32197.11 ENSG00000158106 HEK293_OSMI2_2hA HEK293_TMG_2hB RHPN1 protein_coding   6.245791 8.302005 3.423806 0.96426 0.08047293 -1.275388 1.3591670 1.7336273 0.7857031 0.51107155 0.10549750 -1.1317896 0.21534583 0.20070000 0.23020000 0.02950000 8.474547e-01 2.990074e-15 FALSE FALSE
MSTRG.32197.2 ENSG00000158106 HEK293_OSMI2_2hA HEK293_TMG_2hB RHPN1 protein_coding   6.245791 8.302005 3.423806 0.96426 0.08047293 -1.275388 0.5017029 0.8902784 0.1018497 0.19362353 0.05200136 -3.0088099 0.07558333 0.10553333 0.03046667 -0.07506667 3.605872e-02 2.990074e-15 FALSE TRUE
MSTRG.32197.3 ENSG00000158106 HEK293_OSMI2_2hA HEK293_TMG_2hB RHPN1 protein_coding   6.245791 8.302005 3.423806 0.96426 0.08047293 -1.275388 1.0824724 1.4935513 0.7707490 0.19358964 0.10363920 -0.9454433 0.17480417 0.18043333 0.22573333 0.04530000 6.455894e-01 2.990074e-15 FALSE TRUE
MSTRG.32197.5 ENSG00000158106 HEK293_OSMI2_2hA HEK293_TMG_2hB RHPN1 protein_coding   6.245791 8.302005 3.423806 0.96426 0.08047293 -1.275388 0.6275606 0.0000000 0.4765189 0.00000000 0.02886010 5.6044239 0.11695417 0.00000000 0.13970000 0.13970000 2.990074e-15 2.990074e-15 TRUE TRUE
MSTRG.32197.8 ENSG00000158106 HEK293_OSMI2_2hA HEK293_TMG_2hB RHPN1 protein_coding   6.245791 8.302005 3.423806 0.96426 0.08047293 -1.275388 0.1270042 0.5937066 0.0000000 0.26744870 0.00000000 -5.9157757 0.01448333 0.06713333 0.00000000 -0.06713333 1.052213e-02 2.990074e-15 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158106 E001 0.9556391 0.0130577427 3.002089e-01 4.418660e-01 8 143368839 143368856 18 + 0.396 0.215 -1.220
ENSG00000158106 E002 3.7182573 0.0046409189 2.557723e-02 6.307312e-02 8 143368857 143368866 10 + 0.843 0.524 -1.346
ENSG00000158106 E003 4.9673622 0.0156122698 1.686364e-02 4.463087e-02 8 143368867 143368875 9 + 0.952 0.622 -1.316
ENSG00000158106 E004 11.4870175 0.0188565768 1.043800e-02 2.983447e-02 8 143368876 143368954 79 + 1.228 0.942 -1.037
ENSG00000158106 E005 12.5616901 0.0014166784 8.707407e-03 2.555408e-02 8 143368955 143368987 33 + 1.240 0.998 -0.872
ENSG00000158106 E006 13.8589539 0.0013575928 1.543841e-02 4.148774e-02 8 143368988 143369047 60 + 1.265 1.051 -0.765
ENSG00000158106 E007 13.1395312 0.0027640031 4.262254e-01 5.690866e-01 8 143375553 143375573 21 + 1.144 1.075 -0.248
ENSG00000158106 E008 28.9922884 0.0034603173 7.665447e-02 1.541380e-01 8 143375574 143375668 95 + 1.503 1.385 -0.405
ENSG00000158106 E009 37.1147207 0.0031779877 4.643327e-03 1.494021e-02 8 143376525 143376653 129 + 1.646 1.477 -0.577
ENSG00000158106 E010 37.9679093 0.0007991846 2.171999e-01 3.470076e-01 8 143377380 143377455 76 + 1.577 1.513 -0.220
ENSG00000158106 E011 34.7716951 0.0007290064 8.786385e-01 9.260437e-01 8 143378269 143378346 78 + 1.474 1.496 0.073
ENSG00000158106 E012 22.2924608 0.0052620359 2.358742e-02 5.896216e-02 8 143378451 143378695 245 + 1.421 1.249 -0.599
ENSG00000158106 E013 35.6992943 0.0009819123 8.432301e-03 2.486612e-02 8 143378696 143378758 63 + 1.610 1.458 -0.519
ENSG00000158106 E014 27.3188202 0.0014219773 3.567995e-01 5.011833e-01 8 143378759 143378820 62 + 1.429 1.373 -0.191
ENSG00000158106 E015 47.7770894 0.0005088614 5.236057e-01 6.572457e-01 8 143378912 143379078 167 + 1.641 1.616 -0.083
ENSG00000158106 E016 20.4124223 0.0009866745 3.564366e-01 5.008147e-01 8 143379315 143379324 10 + 1.201 1.291 0.316
ENSG00000158106 E017 21.4422169 0.0010227181 2.303440e-01 3.628727e-01 8 143379325 143379336 12 + 1.201 1.314 0.397
ENSG00000158106 E018 62.1973667 0.0005054933 4.150369e-02 9.381635e-02 8 143379337 143379508 172 + 1.646 1.762 0.394
ENSG00000158106 E019 62.2287283 0.0003895433 7.074764e-01 8.053870e-01 8 143379829 143379985 157 + 1.717 1.747 0.099
ENSG00000158106 E020 11.9509241 0.0017917450 2.471702e-02 6.129654e-02 8 143379986 143380061 76 + 1.202 0.989 -0.769
ENSG00000158106 E021 15.4714570 0.0016787843 4.863355e-01 6.240846e-01 8 143380062 143380064 3 + 1.094 1.172 0.280
ENSG00000158106 E022 47.6600222 0.0034485193 6.091206e-01 7.286577e-01 8 143380065 143380175 111 + 1.641 1.620 -0.070
ENSG00000158106 E023 49.1240606 0.0005258232 1.846947e-03 6.748934e-03 8 143380176 143380588 413 + 1.742 1.589 -0.519
ENSG00000158106 E024 34.9622838 0.0007167736 9.593012e-01 9.784680e-01 8 143380589 143380623 35 + 1.482 1.496 0.048
ENSG00000158106 E025 71.4686125 0.0014689009 8.203899e-01 8.866979e-01 8 143380624 143380783 160 + 1.793 1.794 0.004
ENSG00000158106 E026 50.8242781 0.0011815283 2.914785e-01 4.323499e-01 8 143381268 143381344 77 + 1.687 1.641 -0.159
ENSG00000158106 E027 107.5047590 0.0003011819 9.868520e-01 9.958387e-01 8 143381572 143381718 147 + 1.966 1.976 0.035
ENSG00000158106 E028 108.4610823 0.0002954152 1.150128e-02 3.235212e-02 8 143381807 143381968 162 + 1.895 2.003 0.362
ENSG00000158106 E029 284.7134269 0.0029714168 1.934404e-07 1.858729e-06 8 143382436 143384221 1786 + 2.260 2.438 0.596