ENSG00000158062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357089 ENSG00000158062 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN11 protein_coding protein_coding 29.11996 47.97244 17.42882 3.132865 0.06551206 -1.460204 3.724517 6.857913 2.3016601 4.29118029 1.15109389 -1.5709424 0.12530417 0.13423333 0.13160000 -0.0026333333 1.000000e+00 1.348108e-06 FALSE  
ENST00000374222 ENSG00000158062 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN11 protein_coding protein_coding 29.11996 47.97244 17.42882 3.132865 0.06551206 -1.460204 2.738124 6.026007 1.7091761 3.11622255 1.70917612 -1.8118772 0.09705833 0.13426667 0.09880000 -0.0354666667 5.469619e-01 1.348108e-06 FALSE  
ENST00000374223 ENSG00000158062 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN11 protein_coding protein_coding 29.11996 47.97244 17.42882 3.132865 0.06551206 -1.460204 1.784967 3.037370 1.8277635 0.36185805 0.07432675 -0.7296134 0.06348333 0.06470000 0.10490000 0.0402000000 1.569649e-01 1.348108e-06 FALSE  
ENST00000472155 ENSG00000158062 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN11 protein_coding retained_intron 29.11996 47.97244 17.42882 3.132865 0.06551206 -1.460204 2.960037 2.289839 2.6745123 2.28983907 1.34216815 0.2231271 0.11796250 0.04223333 0.15290000 0.1106666667 4.187904e-01 1.348108e-06 TRUE  
ENST00000475591 ENSG00000158062 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN11 protein_coding retained_intron 29.11996 47.97244 17.42882 3.132865 0.06551206 -1.460204 2.291708 2.791737 1.0971403 1.96867390 1.09714035 -1.3394834 0.08674167 0.06203333 0.06343333 0.0014000000 6.506017e-01 1.348108e-06 TRUE  
ENST00000494942 ENSG00000158062 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN11 protein_coding retained_intron 29.11996 47.97244 17.42882 3.132865 0.06551206 -1.460204 1.661853 2.869288 0.4594586 0.58286157 0.24440047 -2.6166421 0.05307917 0.05876667 0.02640000 -0.0323666667 5.259097e-01 1.348108e-06 FALSE  
MSTRG.609.19 ENSG00000158062 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN11 protein_coding   29.11996 47.97244 17.42882 3.132865 0.06551206 -1.460204 1.552123 2.443790 0.8791077 0.96839462 0.06693366 -1.4645815 0.05657500 0.05130000 0.05046667 -0.0008333333 9.198617e-01 1.348108e-06 TRUE  
MSTRG.609.7 ENSG00000158062 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN11 protein_coding   29.11996 47.97244 17.42882 3.132865 0.06551206 -1.460204 4.442812 8.472148 2.1053163 0.49162646 0.22954437 -2.0035562 0.13683750 0.17736667 0.12073333 -0.0566333333 9.459356e-02 1.348108e-06 FALSE  
MSTRG.609.9 ENSG00000158062 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN11 protein_coding   29.11996 47.97244 17.42882 3.132865 0.06551206 -1.460204 2.589406 5.039174 0.6149231 0.03935459 0.09056196 -3.0142968 0.07240000 0.10583333 0.03533333 -0.0705000000 1.348108e-06 1.348108e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000158062 E001 4.6436772 0.0036180230 1.624728e-01 0.2783679945 1 26281328 26282078 751 - 0.829 0.617 -0.872
ENSG00000158062 E002 0.1482932 0.0411846635 1.000000e+00   1 26282079 26282081 3 - 0.000 0.073 9.276
ENSG00000158062 E003 0.2965864 0.2050427119 8.106598e-01   1 26282082 26282110 29 - 0.000 0.134 9.603
ENSG00000158062 E004 1.0684302 0.0122783957 6.390714e-01 0.7525447394 1 26282111 26282280 170 - 0.197 0.284 0.684
ENSG00000158062 E005 0.6986918 0.0166933613 1.000000e+00 1.0000000000 1 26282281 26282281 1 - 0.197 0.191 -0.053
ENSG00000158062 E006 1.9916005 0.0316947149 1.630273e-01 0.2790858336 1 26282282 26282283 2 - 0.197 0.479 1.810
ENSG00000158062 E007 6.2351573 0.0035597922 4.232283e-02 0.0953140207 1 26282284 26282291 8 - 0.518 0.839 1.360
ENSG00000158062 E008 17.3549245 0.0068490025 1.924664e-04 0.0009316314 1 26282292 26282304 13 - 0.790 1.245 1.681
ENSG00000158062 E009 235.9800249 0.0013140556 1.820546e-05 0.0001140118 1 26282305 26282569 265 - 2.177 2.310 0.446
ENSG00000158062 E010 318.3435730 0.0031240670 7.948493e-03 0.0236487890 1 26282649 26282789 141 - 2.346 2.432 0.287
ENSG00000158062 E011 260.0516829 0.0010864819 1.715231e-02 0.0452785054 1 26282864 26282937 74 - 2.276 2.339 0.212
ENSG00000158062 E012 325.4961653 0.0015209702 1.222845e-01 0.2232027266 1 26284142 26284245 104 - 2.393 2.431 0.125
ENSG00000158062 E013 5.4500886 0.0448587526 8.492304e-01 0.9064204029 1 26284246 26284281 36 - 0.748 0.711 -0.151
ENSG00000158062 E014 346.4629841 0.0001399807 5.052227e-01 0.6410346466 1 26284362 26284482 121 - 2.445 2.449 0.016
ENSG00000158062 E015 271.6068601 0.0065020429 2.504239e-03 0.0087763017 1 26284483 26285459 977 - 2.446 2.313 -0.443
ENSG00000158062 E016 25.0548161 0.0413497781 2.524156e-01 0.3887690639 1 26285460 26285463 4 - 1.420 1.290 -0.452
ENSG00000158062 E017 251.0864483 0.0002772857 3.048345e-01 0.4468567952 1 26285464 26285541 78 - 2.337 2.300 -0.124
ENSG00000158062 E018 210.5116812 0.0002594019 9.603627e-01 0.9790341074 1 26285823 26285875 53 - 2.240 2.231 -0.029
ENSG00000158062 E019 197.0604809 0.0002368294 3.640982e-01 0.5085022841 1 26285876 26285942 67 - 2.190 2.207 0.058
ENSG00000158062 E020 204.5850562 0.0002138079 4.738232e-01 0.6127220470 1 26285943 26286027 85 - 2.214 2.225 0.037
ENSG00000158062 E021 115.3334676 0.0002665870 2.497586e-01 0.3856398175 1 26286028 26286037 10 - 1.946 1.981 0.119
ENSG00000158062 E022 227.8492231 0.0003144210 2.785585e-01 0.4182318503 1 26294205 26294331 127 - 2.252 2.273 0.070
ENSG00000158062 E023 127.7651542 0.0003330990 8.812736e-01 0.9278969088 1 26296919 26296946 28 - 2.023 2.019 -0.015
ENSG00000158062 E024 139.7316920 0.0003814196 7.269855e-01 0.8198692559 1 26296947 26296995 49 - 2.077 2.054 -0.075
ENSG00000158062 E025 157.7513875 0.0002759574 7.721314e-01 0.8529149362 1 26297427 26297481 55 - 2.124 2.104 -0.066
ENSG00000158062 E026 193.1540138 0.0039037022 2.332379e-01 0.3662651113 1 26297962 26298062 101 - 2.241 2.183 -0.193
ENSG00000158062 E027 80.1896708 0.0111273856 9.703778e-04 0.0038571401 1 26300926 26301024 99 - 1.986 1.760 -0.764
ENSG00000158062 E028 10.9868646 0.0038089569 1.483165e-02 0.0401109329 1 26301025 26301053 29 - 1.186 0.914 -0.995
ENSG00000158062 E029 88.9201908 0.0098659605 1.639878e-03 0.0060890171 1 26301694 26301722 29 - 2.014 1.810 -0.686
ENSG00000158062 E030 93.2515069 0.0123346253 4.868940e-03 0.0155648838 1 26302813 26302918 106 - 2.024 1.833 -0.639
ENSG00000158062 E031 0.2998086 0.0297052295 4.166985e-01   1 26302919 26303016 98 - 0.197 0.073 -1.642
ENSG00000158062 E032 10.7890355 0.0081538594 2.178205e-01 0.3477854620 1 26303043 26303167 125 - 1.096 0.943 -0.563
ENSG00000158062 E033 17.2528377 0.0029043899 3.257052e-01 0.4691480087 1 26306288 26306591 304 - 1.247 1.144 -0.364
ENSG00000158062 E034 116.9943179 0.0100936361 7.982261e-01 0.8712088936 1 26306592 26306704 113 - 1.973 1.982 0.029
ENSG00000158062 E035 2.1994440 0.0973908890 6.556263e-01 0.7654731541 1 26306705 26306755 51 - 0.518 0.425 -0.466
ENSG00000158062 E036 0.1482932 0.0411846635 1.000000e+00   1 26306856 26306989 134 - 0.000 0.073 9.276
ENSG00000158062 E037 0.1451727 0.0425071035 1.528692e-01   1 26318047 26318363 317 - 0.197 0.000 -12.328