ENSG00000157985

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304032 ENSG00000157985 HEK293_OSMI2_2hA HEK293_TMG_2hB AGAP1 protein_coding protein_coding 9.015605 8.791148 10.70129 0.6284877 0.6591838 0.2833681 0.3279337 0.02910544 0.7805890 0.02910544 0.2370621 4.33748660 0.03775417 0.003133333 0.07370000 0.07056667 0.004387202 0.004387202 FALSE TRUE
ENST00000409538 ENSG00000157985 HEK293_OSMI2_2hA HEK293_TMG_2hB AGAP1 protein_coding protein_coding 9.015605 8.791148 10.70129 0.6284877 0.6591838 0.2833681 0.5355795 0.36820409 0.7981509 0.07979623 0.1090530 1.09545975 0.05773333 0.040933333 0.07426667 0.03333333 0.172444239 0.004387202 FALSE TRUE
ENST00000428334 ENSG00000157985 HEK293_OSMI2_2hA HEK293_TMG_2hB AGAP1 protein_coding protein_coding 9.015605 8.791148 10.70129 0.6284877 0.6591838 0.2833681 2.1070277 2.07265177 2.0895369 0.16935029 0.2861836 0.01164949 0.23512917 0.238133333 0.19466667 -0.04346667 0.619949111 0.004387202 FALSE TRUE
ENST00000614409 ENSG00000157985 HEK293_OSMI2_2hA HEK293_TMG_2hB AGAP1 protein_coding protein_coding 9.015605 8.791148 10.70129 0.6284877 0.6591838 0.2833681 2.7590095 3.67961706 2.9571940 0.72803803 0.2070733 -0.31437186 0.31097500 0.416333333 0.28100000 -0.13533333 0.333395684 0.004387202 FALSE TRUE
ENST00000635100 ENSG00000157985 HEK293_OSMI2_2hA HEK293_TMG_2hB AGAP1 protein_coding nonsense_mediated_decay 9.015605 8.791148 10.70129 0.6284877 0.6591838 0.2833681 0.5010467 1.10704591 0.0000000 0.57494675 0.0000000 -6.80354467 0.05833333 0.130700000 0.00000000 -0.13070000 0.133185243 0.004387202 FALSE TRUE
MSTRG.20106.4 ENSG00000157985 HEK293_OSMI2_2hA HEK293_TMG_2hB AGAP1 protein_coding   9.015605 8.791148 10.70129 0.6284877 0.6591838 0.2833681 2.4455162 1.32652235 3.8624408 0.35290032 0.4793850 1.53475921 0.26131667 0.146433333 0.35810000 0.21166667 0.010926657 0.004387202 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157985 E001 1.6283858 0.0133403783 1.930768e-04 9.342038e-04 2 235494043 235494088 46 + 0.638 0.000 -13.523
ENSG00000157985 E002 1.9616056 0.0102435916 9.865848e-04 3.912913e-03 2 235494089 235494106 18 + 0.667 0.130 -3.388
ENSG00000157985 E003 2.8558226 0.0146082147 2.684359e-05 1.615348e-04 2 235494107 235494178 72 + 0.811 0.130 -3.973
ENSG00000157985 E004 13.1428757 0.0319875389 4.158421e-06 3.012045e-05 2 235494179 235494701 523 + 1.342 0.799 -1.986
ENSG00000157985 E005 38.1677538 0.0021327525 2.611922e-04 1.221418e-03 2 235494702 235494849 148 + 1.660 1.511 -0.509
ENSG00000157985 E006 0.0000000       2 235524324 235524539 216 +      
ENSG00000157985 E007 22.4852875 0.0100508708 2.651873e-03 9.228498e-03 2 235669604 235671057 1454 + 1.452 1.260 -0.668
ENSG00000157985 E008 0.2214452 0.0393934403 4.978337e-01   2 235709177 235709177 1 + 0.000 0.130 11.696
ENSG00000157985 E009 0.2214452 0.0393934403 4.978337e-01   2 235709178 235709178 1 + 0.000 0.130 11.696
ENSG00000157985 E010 53.7629116 0.0004423516 1.170066e-02 3.282135e-02 2 235709179 235709237 59 + 1.760 1.709 -0.172
ENSG00000157985 E011 61.2297308 0.0003816037 3.117451e-03 1.061166e-02 2 235717557 235717633 77 + 1.822 1.759 -0.211
ENSG00000157985 E012 39.2401269 0.0005733113 5.529937e-02 1.185102e-01 2 235717634 235717644 11 + 1.620 1.583 -0.127
ENSG00000157985 E013 0.1817044 0.0399331383 4.987901e-01   2 235718381 235718392 12 + 0.000 0.130 11.687
ENSG00000157985 E014 67.5767876 0.0026998314 5.722615e-02 1.218537e-01 2 235740963 235741048 86 + 1.845 1.822 -0.078
ENSG00000157985 E015 102.3105863 0.0116116842 1.051534e-02 3.001326e-02 2 235744698 235744839 142 + 2.057 1.967 -0.301
ENSG00000157985 E016 102.0831651 0.0074734498 3.374179e-03 1.136224e-02 2 235750354 235750488 135 + 2.054 1.967 -0.290
ENSG00000157985 E017 95.1008531 0.0035501965 2.301530e-04 1.092339e-03 2 235797759 235797886 128 + 2.026 1.930 -0.323
ENSG00000157985 E018 85.4885404 0.0029645313 3.520076e-02 8.202556e-02 2 235799367 235799522 156 + 1.946 1.922 -0.079
ENSG00000157985 E019 76.3164342 0.0004020020 4.612420e-01 6.012255e-01 2 235807239 235807331 93 + 1.862 1.902 0.136
ENSG00000157985 E020 0.5180316 0.0236378173 8.845648e-02 1.727645e-01 2 235852686 235853202 517 + 0.000 0.311 13.465
ENSG00000157985 E021 53.7413877 0.0004569076 5.466161e-02 1.174065e-01 2 235883345 235883394 50 + 1.746 1.724 -0.075
ENSG00000157985 E022 50.6182072 0.0004887908 1.149462e-02 3.233673e-02 2 235883395 235883449 55 + 1.734 1.679 -0.187
ENSG00000157985 E023 72.7711652 0.0004585181 6.249889e-03 1.926963e-02 2 235908738 235908841 104 + 1.888 1.845 -0.145
ENSG00000157985 E024 71.9511814 0.0003386645 5.381675e-02 1.159361e-01 2 235908842 235908906 65 + 1.865 1.856 -0.032
ENSG00000157985 E025 24.1308920 0.0008197312 2.938028e-01 4.348476e-01 2 235930765 235930923 159 + 1.403 1.399 -0.016
ENSG00000157985 E026 88.3821284 0.0003906565 1.406409e-02 3.836992e-02 2 235968462 235968623 162 + 1.959 1.937 -0.075
ENSG00000157985 E027 0.4407149 0.0214598159 5.518932e-01 6.812967e-01 2 236014805 236014879 75 + 0.206 0.130 -0.805
ENSG00000157985 E028 91.4307547 0.0003655250 1.764901e-01 2.966904e-01 2 236036561 236036715 155 + 1.950 1.970 0.068
ENSG00000157985 E029 0.5159433 0.2122700574 6.203702e-01 7.375530e-01 2 236040612 236040750 139 + 0.206 0.131 -0.781
ENSG00000157985 E030 89.1483008 0.0003464836 3.059688e-01 4.481173e-01 2 236040751 236040841 91 + 1.935 1.967 0.107
ENSG00000157985 E031 0.0000000       2 236045937 236046031 95 +      
ENSG00000157985 E032 143.6342883 0.0002644385 7.166124e-02 1.461121e-01 2 236049059 236049281 223 + 2.151 2.168 0.060
ENSG00000157985 E033 1.4266447 0.0942865410 3.432042e-01 4.872674e-01 2 236049282 236049831 550 + 0.451 0.312 -0.796
ENSG00000157985 E034 118.8588648 0.0002701155 5.963031e-01 7.182777e-01 2 236120192 236120447 256 + 2.028 2.116 0.294
ENSG00000157985 E035 1442.8386548 0.0049296611 9.660083e-09 1.194877e-07 2 236123919 236131800 7882 + 3.052 3.241 0.628