ENSG00000157954

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288828 ENSG00000157954 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPI2 protein_coding protein_coding 73.92832 88.99284 67.04545 8.226251 1.845356 -0.4084968 14.287743 18.43476 10.930987 1.7612043 0.4937914 -0.7534679 0.19231250 0.2116667 0.1633333 -0.048333333 0.516497638 0.001689005 FALSE TRUE
ENST00000382384 ENSG00000157954 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPI2 protein_coding protein_coding 73.92832 88.99284 67.04545 8.226251 1.845356 -0.4084968 11.460925 17.28866 9.735557 1.8620930 0.5516713 -0.8278434 0.15229583 0.1945667 0.1451333 -0.049433333 0.104077580 0.001689005 FALSE TRUE
ENST00000401525 ENSG00000157954 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPI2 protein_coding protein_coding 73.92832 88.99284 67.04545 8.226251 1.845356 -0.4084968 6.697314 10.75691 5.904550 2.4997029 0.4959086 -0.8642643 0.08814583 0.1181667 0.0881000 -0.030066667 0.425941967 0.001689005 FALSE TRUE
ENST00000465102 ENSG00000157954 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPI2 protein_coding retained_intron 73.92832 88.99284 67.04545 8.226251 1.845356 -0.4084968 12.382190 5.51961 13.738119 0.9240965 1.8311678 1.3139846 0.17373750 0.0645000 0.2041667 0.139666667 0.001689005 0.001689005 FALSE TRUE
ENST00000480238 ENSG00000157954 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPI2 protein_coding processed_transcript 73.92832 88.99284 67.04545 8.226251 1.845356 -0.4084968 16.687185 20.99413 15.253143 3.1989272 1.2751136 -0.4606211 0.22505833 0.2352667 0.2270333 -0.008233333 0.961665509 0.001689005 FALSE FALSE
ENST00000496867 ENSG00000157954 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPI2 protein_coding processed_transcript 73.92832 88.99284 67.04545 8.226251 1.845356 -0.4084968 10.131620 14.06856 8.923594 3.5362152 0.7292936 -0.6561871 0.13686667 0.1537333 0.1338000 -0.019933333 0.810598712 0.001689005 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157954 E001 3.0323225 0.1318539669 7.758373e-01 8.556246e-01 7 5190196 5190232 37 + 0.603 0.551 -0.234
ENSG00000157954 E002 10.8759684 0.1259432127 4.163039e-02 9.405788e-02 7 5190233 5190245 13 + 1.260 0.875 -1.403
ENSG00000157954 E003 15.7755513 0.0675086798 1.038828e-02 2.971507e-02 7 5190246 5190254 9 + 1.406 1.030 -1.331
ENSG00000157954 E004 17.0300540 0.0852840366 2.415450e-02 6.013136e-02 7 5190255 5190258 4 + 1.428 1.073 -1.249
ENSG00000157954 E005 18.2049602 0.0617630377 2.645627e-02 6.486090e-02 7 5190259 5190264 6 + 1.434 1.122 -1.095
ENSG00000157954 E006 20.5793956 0.0611358092 4.806761e-03 1.539260e-02 7 5190265 5190272 8 + 1.527 1.130 -1.386
ENSG00000157954 E007 31.6580243 0.0626229010 2.751326e-05 1.651293e-04 7 5190273 5190282 10 + 1.786 1.197 -2.026
ENSG00000157954 E008 242.3114491 0.0014671285 3.046225e-13 8.078083e-12 7 5190283 5190493 211 + 2.485 2.281 -0.679
ENSG00000157954 E009 0.9578041 0.0121989077 1.848139e-02 4.818932e-02 7 5190693 5190843 151 + 0.497 0.096 -3.114
ENSG00000157954 E010 107.7024569 0.0004568452 2.561510e-05 1.548949e-04 7 5193118 5193171 54 + 2.099 1.961 -0.463
ENSG00000157954 E011 5.6454064 0.0029101850 8.357038e-04 3.386485e-03 7 5193172 5193345 174 + 1.036 0.625 -1.617
ENSG00000157954 E012 382.6513142 0.0009779658 2.579061e-02 6.351004e-02 7 5199576 5199658 83 + 2.586 2.543 -0.143
ENSG00000157954 E013 8.1905125 0.0213890975 1.410709e-01 2.495049e-01 7 5213110 5213402 293 + 1.052 0.871 -0.679
ENSG00000157954 E014 0.5244761 0.3008338342 3.917430e-01 5.356671e-01 7 5214186 5214268 83 + 0.270 0.098 -1.770
ENSG00000157954 E015 0.6727692 0.1021581886 5.999901e-01 7.212899e-01 7 5214269 5214534 266 + 0.269 0.175 -0.793
ENSG00000157954 E016 308.6194088 0.0005554238 6.844641e-01 7.874334e-01 7 5214535 5214560 26 + 2.465 2.466 0.004
ENSG00000157954 E017 701.9177542 0.0007346731 4.584620e-03 1.477767e-02 7 5214561 5214704 144 + 2.849 2.807 -0.139
ENSG00000157954 E018 0.1515154 0.0436157769 2.823152e-01   7 5216172 5216250 79 + 0.155 0.000 -10.958
ENSG00000157954 E019 325.9073945 0.0001629102 7.446955e-04 3.059846e-03 7 5216563 5216564 2 + 2.529 2.470 -0.194
ENSG00000157954 E020 433.2372572 0.0001423945 1.225905e-02 3.415505e-02 7 5216565 5216590 26 + 2.636 2.602 -0.112
ENSG00000157954 E021 626.9057426 0.0001220612 4.932507e-03 1.574206e-02 7 5216591 5216659 69 + 2.793 2.762 -0.104
ENSG00000157954 E022 0.3697384 0.0252787873 4.029922e-01 5.467947e-01 7 5216749 5216863 115 + 0.000 0.175 10.737
ENSG00000157954 E023 650.9990119 0.0005836297 1.581022e-01 2.725907e-01 7 5217090 5217187 98 + 2.798 2.782 -0.055
ENSG00000157954 E024 1.5791025 0.0088125262 7.915285e-01 8.666433e-01 7 5217188 5217921 734 + 0.434 0.395 -0.210
ENSG00000157954 E025 672.9434616 0.0005341663 1.017331e-01 1.931359e-01 7 5217922 5218014 93 + 2.815 2.795 -0.065
ENSG00000157954 E026 3.5270025 0.0793588372 1.094289e-01 2.047207e-01 7 5218015 5219031 1017 + 0.817 0.535 -1.197
ENSG00000157954 E027 574.4183883 0.0001259159 1.430026e-01 2.521243e-01 7 5222602 5222672 71 + 2.742 2.730 -0.041
ENSG00000157954 E028 7.8899905 0.0020617075 3.087242e-03 1.052239e-02 7 5222673 5222812 140 + 1.114 0.792 -1.208
ENSG00000157954 E029 595.2943748 0.0001870917 1.358155e-01 2.422336e-01 7 5225823 5225930 108 + 2.725 2.759 0.115
ENSG00000157954 E030 2.7145455 0.1001562587 2.043672e-01 3.316183e-01 7 5225931 5225949 19 + 0.686 0.442 -1.122
ENSG00000157954 E031 24.3214606 0.0234143499 8.910740e-02 1.737692e-01 7 5225950 5227179 1230 + 1.479 1.310 -0.586
ENSG00000157954 E032 769.8373592 0.0001343500 2.935060e-03 1.007261e-02 7 5227180 5227344 165 + 2.824 2.877 0.175
ENSG00000157954 E033 644.9576459 0.0001077139 1.468180e-02 3.977245e-02 7 5228104 5228211 108 + 2.753 2.801 0.160
ENSG00000157954 E034 6.5570080 0.0035377598 7.751272e-02 1.554678e-01 7 5229408 5229607 200 + 0.981 0.774 -0.793
ENSG00000157954 E035 676.9950651 0.0002258023 4.476832e-02 9.978379e-02 7 5229608 5229705 98 + 2.778 2.820 0.141
ENSG00000157954 E036 305.5131797 0.0002660362 1.257220e-01 2.281756e-01 7 5229706 5229738 33 + 2.431 2.477 0.153
ENSG00000157954 E037 4.8724232 0.0033058509 8.302442e-01 8.934838e-01 7 5230802 5230834 33 + 0.757 0.736 -0.083
ENSG00000157954 E038 2653.9304654 0.0009179724 3.059250e-11 5.883319e-10 7 5230835 5233840 3006 + 3.328 3.425 0.322