ENSG00000157927

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399583 ENSG00000157927 HEK293_OSMI2_2hA HEK293_TMG_2hB RADIL protein_coding protein_coding 8.825804 14.83366 4.4992 1.418 0.1703043 -1.718903 0.7780617 0.5423259 0.4654626 0.5423259 0.2355192 -0.2161881 0.10291667 0.04273333 0.1059667 0.0632333333 4.984866e-01 5.06243e-12 FALSE TRUE
ENST00000457174 ENSG00000157927 HEK293_OSMI2_2hA HEK293_TMG_2hB RADIL protein_coding protein_coding 8.825804 14.83366 4.4992 1.418 0.1703043 -1.718903 0.4576089 0.2419748 0.5235674 0.1263096 0.2621793 1.0823912 0.06130417 0.01563333 0.1122000 0.0965666667 5.736781e-01 5.06243e-12 FALSE FALSE
ENST00000473130 ENSG00000157927 HEK293_OSMI2_2hA HEK293_TMG_2hB RADIL protein_coding retained_intron 8.825804 14.83366 4.4992 1.418 0.1703043 -1.718903 1.5621147 4.9925311 0.0000000 0.8851409 0.0000000 -8.9665144 0.12240833 0.34153333 0.0000000 -0.3415333333 5.062430e-12 5.06243e-12 FALSE TRUE
MSTRG.29422.1 ENSG00000157927 HEK293_OSMI2_2hA HEK293_TMG_2hB RADIL protein_coding   8.825804 14.83366 4.4992 1.418 0.1703043 -1.718903 0.5250619 1.2771263 0.3782758 0.6431601 0.3782758 -1.7289999 0.05955833 0.08056667 0.0800000 -0.0005666667 7.037141e-01 5.06243e-12 TRUE TRUE
MSTRG.29422.4 ENSG00000157927 HEK293_OSMI2_2hA HEK293_TMG_2hB RADIL protein_coding   8.825804 14.83366 4.4992 1.418 0.1703043 -1.718903 4.9625705 7.1854334 2.8496332 1.2982602 0.1859112 -1.3312515 0.59362500 0.48086667 0.6384000 0.1575333333 4.196107e-01 5.06243e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157927 E001 1.5770116 0.0091320969 9.936906e-01 1.000000e+00 7 4794909 4794942 34 - 0.350 0.342 -0.053
ENSG00000157927 E002 0.0000000       7 4797055 4797055 1 -      
ENSG00000157927 E003 13.5640390 0.0153578672 4.589014e-03 1.478906e-02 7 4797056 4799104 2049 - 1.306 0.980 -1.171
ENSG00000157927 E004 1.1769825 0.0110797849 6.066378e-01 7.267248e-01 7 4799105 4799108 4 - 0.210 0.306 0.723
ENSG00000157927 E005 137.4672191 0.0013758616 2.590471e-01 3.964164e-01 7 4799109 4799483 375 - 2.001 2.035 0.113
ENSG00000157927 E006 110.0576238 0.0002782511 6.673538e-01 7.746303e-01 7 4799630 4799769 140 - 1.925 1.930 0.017
ENSG00000157927 E007 97.0889302 0.0003036093 3.369226e-03 1.134878e-02 7 4800171 4800310 140 - 1.773 1.896 0.416
ENSG00000157927 E008 154.3413849 0.0019915660 2.062228e-05 1.275366e-04 7 4801653 4801995 343 - 1.931 2.102 0.574
ENSG00000157927 E009 120.5890426 0.0003405836 2.779207e-03 9.611400e-03 7 4803546 4803754 209 - 1.874 1.986 0.376
ENSG00000157927 E010 3.0603228 0.0080023857 3.892800e-02 8.905464e-02 7 4803755 4804068 314 - 0.775 0.433 -1.537
ENSG00000157927 E011 1.5823963 0.0132979367 4.924151e-01 6.296042e-01 7 4805245 4805565 321 - 0.210 0.342 0.952
ENSG00000157927 E012 78.1177956 0.0003618536 4.879116e-02 1.070103e-01 7 4805566 4805716 151 - 1.710 1.797 0.296
ENSG00000157927 E013 85.0150461 0.0003299291 8.921573e-03 2.608400e-02 7 4815278 4815450 173 - 1.720 1.837 0.395
ENSG00000157927 E014 105.7836905 0.0006614293 6.479860e-02 1.347135e-01 7 4816228 4816465 238 - 1.856 1.925 0.234
ENSG00000157927 E015 71.8772604 0.0059870253 4.707589e-01 6.099710e-01 7 4817239 4817351 113 - 1.725 1.760 0.118
ENSG00000157927 E016 84.3615481 0.0039572975 5.599175e-01 6.879950e-01 7 4822394 4822550 157 - 1.804 1.825 0.072
ENSG00000157927 E017 38.0515988 0.0006238555 4.614909e-01 6.014382e-01 7 4822551 4822554 4 - 1.530 1.468 -0.213
ENSG00000157927 E018 52.5747418 0.0004331705 1.252965e-01 2.275574e-01 7 4832141 4832178 38 - 1.694 1.594 -0.338
ENSG00000157927 E019 0.0000000       7 4832179 4832219 41 -      
ENSG00000157927 E020 61.3534751 0.0004237654 1.609155e-02 4.294199e-02 7 4834607 4834687 81 - 1.786 1.649 -0.465
ENSG00000157927 E021 81.1986383 0.0009673562 7.916898e-03 2.357026e-02 7 4834688 4835029 342 - 1.908 1.773 -0.456
ENSG00000157927 E022 64.6785914 0.0004284429 3.492726e-01 4.934939e-01 7 4835030 4835234 205 - 1.671 1.710 0.130
ENSG00000157927 E023 26.0769672 0.0008929749 6.178496e-01 7.355883e-01 7 4835235 4835239 5 - 1.292 1.322 0.104
ENSG00000157927 E024 76.3611354 0.0065727986 7.223470e-01 8.164756e-01 7 4836358 4836605 248 - 1.795 1.767 -0.094
ENSG00000157927 E025 64.1161928 0.0167958844 6.113066e-02 1.285366e-01 7 4877605 4877737 133 - 1.817 1.669 -0.500
ENSG00000157927 E026 120.5000395 0.0068386975 1.421267e-06 1.142072e-05 7 4877738 4878203 466 - 2.163 1.914 -0.836
ENSG00000157927 E027 0.9921577 0.0127912119 5.319781e-01 6.643616e-01 7 4882109 4882209 101 - 0.350 0.226 -0.861
ENSG00000157927 E028 21.4282434 0.0049406653 6.502659e-09 8.305753e-08 7 4883596 4883716 121 - 1.582 1.097 -1.695