ENSG00000157895

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288757 ENSG00000157895 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf43 protein_coding protein_coding 23.58536 24.59881 27.27061 2.356201 1.181713 0.148701 3.591735 4.744629 2.924028 0.4173694 0.2161629 -0.69645016 0.1547000 0.1932333 0.1069333 -0.08630000 1.326476e-06 1.326476e-06 FALSE TRUE
ENST00000445832 ENSG00000157895 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf43 protein_coding protein_coding 23.58536 24.59881 27.27061 2.356201 1.181713 0.148701 9.767142 11.033003 10.706997 1.7649206 0.3093598 -0.04323185 0.4173292 0.4430000 0.3938667 -0.04913333 5.797145e-01 1.326476e-06 FALSE TRUE
MSTRG.8180.3 ENSG00000157895 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf43 protein_coding   23.58536 24.59881 27.27061 2.356201 1.181713 0.148701 9.157389 7.665242 12.404093 0.2666028 0.8362674 0.69369467 0.3821417 0.3173000 0.4538667 0.13656667 1.991767e-02 1.326476e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157895 E001 166.2401773 0.0002811032 2.947799e-15 1.050116e-13 12 121000486 121002421 1936 - 2.067 2.306 0.800
ENSG00000157895 E002 712.3828898 0.0019049443 1.302278e-04 6.598360e-04 12 121002422 121003790 1369 - 2.797 2.885 0.291
ENSG00000157895 E003 77.6176473 0.0003789700 9.950407e-01 1.000000e+00 12 121003791 121003792 2 - 1.887 1.900 0.044
ENSG00000157895 E004 161.0925813 0.0002626537 4.888158e-01 6.263337e-01 12 121003793 121003875 83 - 2.189 2.222 0.109
ENSG00000157895 E005 107.8193116 0.0002802349 9.043509e-01 9.430907e-01 12 121003876 121003891 16 - 2.030 2.040 0.032
ENSG00000157895 E006 341.1920242 0.0001599563 1.493014e-02 4.033009e-02 12 121003892 121004215 324 - 2.552 2.520 -0.106
ENSG00000157895 E007 108.3383117 0.0003276570 2.165224e-02 5.495575e-02 12 121004216 121004241 26 - 2.072 2.008 -0.217
ENSG00000157895 E008 251.0871972 0.0020871381 5.019544e-02 1.095020e-01 12 121004242 121004489 248 - 2.427 2.375 -0.171
ENSG00000157895 E009 50.0585015 0.0004593485 2.643278e-01 4.022856e-01 12 121004490 121004492 3 - 1.729 1.687 -0.142
ENSG00000157895 E010 115.3099211 0.0003108006 3.600922e-03 1.201386e-02 12 121005003 121005060 58 - 2.111 2.029 -0.274
ENSG00000157895 E011 93.2929282 0.0003539338 1.052536e-02 3.003731e-02 12 121005061 121005093 33 - 2.018 1.938 -0.267
ENSG00000157895 E012 5.7432453 0.0032153192 8.319380e-01 8.946927e-01 12 121005924 121006320 397 - 0.843 0.828 -0.057
ENSG00000157895 E013 136.0504707 0.0003370901 1.494325e-03 5.617417e-03 12 121006321 121006394 74 - 2.182 2.100 -0.276
ENSG00000157895 E014 2.1068854 0.7512457849 4.339775e-01 5.763668e-01 12 121006395 121007229 835 - 0.315 0.565 1.329
ENSG00000157895 E015 161.1338074 0.0002253023 1.184470e-03 4.588337e-03 12 121010828 121010926 99 - 2.252 2.176 -0.252
ENSG00000157895 E016 2.6332383 0.0147159915 8.989801e-01 9.395534e-01 12 121011011 121011103 93 - 0.539 0.570 0.145
ENSG00000157895 E017 103.7781179 0.0007206171 1.613674e-01 2.768696e-01 12 121011104 121011146 43 - 2.042 2.006 -0.121
ENSG00000157895 E018 6.8502966 0.0025117414 5.220622e-01 6.559302e-01 12 121012430 121012686 257 - 0.843 0.932 0.339
ENSG00000157895 E019 0.2924217 0.0270021252 1.604439e-01   12 121016259 121016329 71 - 0.231 0.000 -10.699
ENSG00000157895 E020 109.4177399 0.0002596577 9.745474e-01 9.881295e-01 12 121016330 121016502 173 - 2.035 2.047 0.041