ENSG00000157890

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395614 ENSG00000157890 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF11 protein_coding protein_coding 2.84091 4.324475 1.717572 0.4885856 0.3140817 -1.327112 0.72816721 1.05742637 0.46316685 0.06472291 0.05743384 -1.1737157 0.28994583 0.24776667 0.28030000 0.03253333 0.85219401 0.01413354 FALSE TRUE
ENST00000422354 ENSG00000157890 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF11 protein_coding protein_coding 2.84091 4.324475 1.717572 0.4885856 0.3140817 -1.327112 0.04375035 0.03346302 0.07382271 0.03346302 0.07382271 0.9475526 0.01888333 0.00670000 0.06066667 0.05396667 0.87983530 0.01413354 FALSE TRUE
ENST00000455812 ENSG00000157890 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF11 protein_coding protein_coding 2.84091 4.324475 1.717572 0.4885856 0.3140817 -1.327112 0.38994425 0.91261642 0.15829368 0.46800996 0.15829368 -2.4547500 0.10098333 0.18940000 0.09656667 -0.09283333 0.66532714 0.01413354 FALSE FALSE
ENST00000478590 ENSG00000157890 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF11 protein_coding retained_intron 2.84091 4.324475 1.717572 0.4885856 0.3140817 -1.327112 0.10168263 0.00000000 0.11910418 0.00000000 0.11910418 3.6904638 0.03965417 0.00000000 0.09786667 0.09786667 0.71023443 0.01413354 FALSE FALSE
ENST00000484618 ENSG00000157890 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF11 protein_coding processed_transcript 2.84091 4.324475 1.717572 0.4885856 0.3140817 -1.327112 0.03469314 0.00000000 0.27754512 0.00000000 0.27754512 4.8457165 0.01510833 0.00000000 0.12086667 0.12086667 0.65645962 0.01413354 FALSE FALSE
ENST00000493192 ENSG00000157890 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF11 protein_coding processed_transcript 2.84091 4.324475 1.717572 0.4885856 0.3140817 -1.327112 0.23208925 0.25169705 0.08790374 0.13266199 0.08790374 -1.4184618 0.07883750 0.06653333 0.03826667 -0.02826667 0.81291566 0.01413354 FALSE FALSE
ENST00000562154 ENSG00000157890 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF11 protein_coding nonsense_mediated_decay 2.84091 4.324475 1.717572 0.4885856 0.3140817 -1.327112 0.59882998 0.89035301 0.10351822 0.15730215 0.03761299 -2.9875669 0.19574583 0.20963333 0.05736667 -0.15226667 0.01413354 0.01413354   FALSE
ENST00000564573 ENSG00000157890 HEK293_OSMI2_2hA HEK293_TMG_2hB MEGF11 protein_coding protein_coding 2.84091 4.324475 1.717572 0.4885856 0.3140817 -1.327112 0.46602795 0.99821767 0.17665928 0.08498850 0.09383406 -2.4333280 0.15879167 0.23323333 0.09553333 -0.13770000 0.22033615 0.01413354   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157890 E001 0.0000000       15 65895079 65895295 217 -      
ENSG00000157890 E002 0.0000000       15 65895296 65895298 3 -      
ENSG00000157890 E003 25.2771183 0.0009540920 3.022579e-10 4.916024e-09 15 65895299 65898094 2796 - 1.631 1.210 -1.455
ENSG00000157890 E004 1.0653228 0.0480909784 7.529811e-01 8.390684e-01 15 65898728 65898732 5 - 0.313 0.257 -0.392
ENSG00000157890 E005 12.0118531 0.0087751268 7.370121e-01 8.273003e-01 15 65898733 65898934 202 - 1.083 1.049 -0.124
ENSG00000157890 E006 0.3268771 0.0292440774 4.755925e-01   15 65901772 65902195 424 - 0.184 0.079 -1.399
ENSG00000157890 E007 0.9264943 0.0260855171 2.485053e-01 3.841707e-01 15 65902196 65902495 300 - 0.413 0.204 -1.404
ENSG00000157890 E008 0.2998086 0.0301888670 4.751301e-01   15 65902496 65902537 42 - 0.184 0.079 -1.402
ENSG00000157890 E009 9.4300517 0.0243273965 3.739188e-03 1.240809e-02 15 65905274 65905783 510 - 0.561 1.027 1.868
ENSG00000157890 E010 2.5691798 0.0062990924 5.353959e-03 1.689416e-02 15 65905784 65905836 53 - 0.000 0.581 13.307
ENSG00000157890 E011 1.4297626 0.0098592463 3.127132e-01 4.552499e-01 15 65905837 65905874 38 - 0.184 0.381 1.409
ENSG00000157890 E012 15.1293541 0.0047419658 3.113975e-01 4.538513e-01 15 65906085 65906141 57 - 1.063 1.170 0.385
ENSG00000157890 E013 2.1670770 0.0079260531 7.278913e-01 8.204530e-01 15 65906625 65906670 46 - 0.413 0.477 0.337
ENSG00000157890 E014 15.8661004 0.0310781094 3.112206e-01 4.536731e-01 15 65909034 65909121 88 - 1.063 1.196 0.476
ENSG00000157890 E015 7.4485250 0.0100455409 9.948349e-01 1.000000e+00 15 65909122 65909135 14 - 0.866 0.870 0.016
ENSG00000157890 E016 11.7535911 0.0016320137 6.959801e-02 1.426870e-01 15 65909740 65909806 67 - 0.866 1.080 0.798
ENSG00000157890 E017 1.1457494 0.0111501042 3.852490e-01 5.294398e-01 15 65909916 65909986 71 - 0.413 0.256 -0.985
ENSG00000157890 E018 15.3159754 0.0013525088 7.815976e-02 1.565087e-01 15 65912082 65912200 119 - 0.999 1.183 0.663
ENSG00000157890 E019 0.9641442 0.1465721849 7.484746e-01 8.357180e-01 15 65912437 65912478 42 - 0.184 0.260 0.628
ENSG00000157890 E020 0.6759915 0.5961082560 2.322581e-01 3.651200e-01 15 65913526 65913736 211 - 0.415 0.082 -2.944
ENSG00000157890 E021 26.0705952 0.0009006728 5.336310e-01 6.658026e-01 15 65913737 65913973 237 - 1.324 1.374 0.174
ENSG00000157890 E022 0.9504423 0.2834734667 1.126952e-01 2.094809e-01 15 65913974 65914118 145 - 0.493 0.147 -2.388
ENSG00000157890 E023 18.2888583 0.0010552544 8.741271e-03 2.563916e-02 15 65915470 65915598 129 - 0.999 1.261 0.940
ENSG00000157890 E024 13.0584318 0.0014771652 3.860137e-01 5.302056e-01 15 65916148 65916276 129 - 0.999 1.095 0.347
ENSG00000157890 E025 0.6537541 0.4107393127 4.472290e-01 5.886344e-01 15 65916598 65916827 230 - 0.312 0.147 -1.382
ENSG00000157890 E026 8.9457246 0.0038393321 8.263038e-01 8.906964e-01 15 65916828 65916956 129 - 0.896 0.926 0.113
ENSG00000157890 E027 12.6224845 0.0587711200 4.524733e-01 5.933186e-01 15 65917966 65918094 129 - 0.951 1.091 0.512
ENSG00000157890 E028 7.2354687 0.0024105632 5.196013e-02 1.126577e-01 15 65921692 65922107 416 - 0.620 0.904 1.146
ENSG00000157890 E029 15.5871520 0.0020525554 4.442221e-02 9.915136e-02 15 65922338 65922472 135 - 0.976 1.189 0.772
ENSG00000157890 E030 15.3134865 0.0012410881 9.811944e-01 9.922775e-01 15 65922823 65922969 147 - 1.136 1.141 0.017
ENSG00000157890 E031 12.7390227 0.0023165325 2.599998e-01 3.974803e-01 15 65928425 65928527 103 - 1.153 1.042 -0.399
ENSG00000157890 E032 6.3688948 0.0033810158 5.698843e-01 6.963999e-01 15 65929720 65929720 1 - 0.866 0.793 -0.284
ENSG00000157890 E033 13.3905802 0.0014162855 3.158939e-01 4.586714e-01 15 65929721 65929883 163 - 0.999 1.108 0.397
ENSG00000157890 E034 11.9565392 0.0017282547 8.626837e-01 9.154568e-01 15 65930823 65930943 121 - 1.022 1.043 0.076
ENSG00000157890 E035 21.9644631 0.0330560294 5.851646e-01 7.089175e-01 15 65957547 65957721 175 - 1.227 1.302 0.264
ENSG00000157890 E036 16.7712346 0.0049067216 6.405858e-01 7.538079e-01 15 65964908 65964951 44 - 1.136 1.184 0.172
ENSG00000157890 E037 18.1906802 0.0188259005 6.377446e-01 7.515664e-01 15 65964952 65965046 95 - 1.240 1.196 -0.156
ENSG00000157890 E038 12.5945136 0.0033503228 7.433021e-01 8.319655e-01 15 65965047 65965120 74 - 1.083 1.051 -0.116
ENSG00000157890 E039 0.1482932 0.0425615954 1.000000e+00   15 65965175 65965383 209 - 0.000 0.079 9.495
ENSG00000157890 E040 0.0000000       15 65967072 65967136 65 -      
ENSG00000157890 E041 15.0427563 0.0012717152 1.770833e-02 4.650518e-02 15 65970553 65970689 137 - 1.290 1.080 -0.747
ENSG00000157890 E042 0.0000000       15 65970690 65971165 476 -      
ENSG00000157890 E043 0.0000000       15 65971166 65971203 38 -      
ENSG00000157890 E044 0.0000000       15 65971204 65971264 61 -      
ENSG00000157890 E045 11.6528005 0.0023046142 1.300406e-01 2.342193e-01 15 65980778 65980898 121 - 1.153 1.001 -0.552
ENSG00000157890 E046 11.2851969 0.0018909788 4.286773e-01 5.714002e-01 15 65982242 65982488 247 - 1.083 1.001 -0.299
ENSG00000157890 E047 9.8052112 0.0018292642 2.372509e-01 3.709924e-01 15 66094402 66094494 93 - 1.063 0.935 -0.473
ENSG00000157890 E048 11.7779088 0.0015312309 9.761226e-01 9.890803e-01 15 66119086 66119186 101 - 1.043 1.042 -0.003
ENSG00000157890 E049 11.1887754 0.0016773471 7.994449e-01 8.720752e-01 15 66123899 66124000 102 - 1.043 1.018 -0.093
ENSG00000157890 E050 8.6102682 0.0020471253 9.210537e-01 9.541784e-01 15 66128306 66128411 106 - 0.924 0.915 -0.036
ENSG00000157890 E051 0.2987644 0.0271169975 4.365714e-02   15 66128412 66128433 22 - 0.313 0.000 -13.573
ENSG00000157890 E052 8.0372696 0.0542046782 5.400280e-01 6.712289e-01 15 66253605 66253786 182 - 0.952 0.864 -0.331