ENSG00000157881

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378466 ENSG00000157881 HEK293_OSMI2_2hA HEK293_TMG_2hB PANK4 protein_coding protein_coding 36.74925 43.61291 28.50803 0.9472138 0.4503157 -0.6132116 18.8696247 27.884975 11.824832 1.6552780 0.6999272 -1.2369661 0.4990375 0.6407000 0.4154667 -0.22523333 0.008408004 0.008408004 FALSE TRUE
ENST00000486396 ENSG00000157881 HEK293_OSMI2_2hA HEK293_TMG_2hB PANK4 protein_coding nonsense_mediated_decay 36.74925 43.61291 28.50803 0.9472138 0.4503157 -0.6132116 0.9212966 0.761747 2.067524 0.3145034 0.3544637 1.4286649 0.0280750 0.0173000 0.0722000 0.05490000 0.058418199 0.008408004 FALSE FALSE
ENST00000515423 ENSG00000157881 HEK293_OSMI2_2hA HEK293_TMG_2hB PANK4 protein_coding retained_intron 36.74925 43.61291 28.50803 0.9472138 0.4503157 -0.6132116 5.1885309 4.923661 4.388320 0.6883395 0.4051169 -0.1657062 0.1443458 0.1125667 0.1536333 0.04106667 0.310541444 0.008408004   FALSE
MSTRG.146.3 ENSG00000157881 HEK293_OSMI2_2hA HEK293_TMG_2hB PANK4 protein_coding   36.74925 43.61291 28.50803 0.9472138 0.4503157 -0.6132116 6.4454849 5.415185 5.911282 1.2211670 0.3230292 0.1262371 0.1847000 0.1232667 0.2072667 0.08400000 0.113868498 0.008408004 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157881 E001 40.6140427 0.0011047769 1.557024e-03 5.819857e-03 1 2508537 2508657 121 - 1.410 1.625 0.738
ENSG00000157881 E002 123.9825645 0.0013368529 3.834836e-04 1.710736e-03 1 2508658 2508794 137 - 1.943 2.094 0.509
ENSG00000157881 E003 279.4639265 0.0083908815 6.543595e-03 2.003757e-02 1 2508795 2509060 266 - 2.294 2.444 0.501
ENSG00000157881 E004 8.4475433 0.0022088444 2.600496e-01 3.975310e-01 1 2509793 2509861 69 - 1.014 0.893 -0.450
ENSG00000157881 E005 163.9037618 0.0100286703 4.745114e-02 1.046383e-01 1 2509862 2509930 69 - 2.079 2.209 0.435
ENSG00000157881 E006 240.7531315 0.0050948417 5.881412e-02 1.246015e-01 1 2510057 2510157 101 - 2.273 2.366 0.313
ENSG00000157881 E007 19.4260322 0.0128283341 1.636682e-02 4.353554e-02 1 2510293 2510677 385 - 1.410 1.197 -0.744
ENSG00000157881 E008 194.8125733 0.0014355777 4.782006e-01 6.166458e-01 1 2510678 2510748 71 - 2.226 2.260 0.114
ENSG00000157881 E009 115.0807011 0.0056502861 9.097959e-02 1.766815e-01 1 2510749 2510782 34 - 1.952 2.050 0.331
ENSG00000157881 E010 178.1788178 0.0056632718 5.096089e-01 6.449157e-01 1 2511338 2511387 50 - 2.182 2.224 0.142
ENSG00000157881 E011 197.2368389 0.0002089225 3.493927e-01 4.936010e-01 1 2511628 2511683 56 - 2.228 2.264 0.120
ENSG00000157881 E012 4.4774287 0.0230070669 1.201914e-01 2.202693e-01 1 2512406 2512887 482 - 0.848 0.622 -0.923
ENSG00000157881 E013 287.8434095 0.0048805452 8.075290e-01 8.777249e-01 1 2512888 2513039 152 - 2.403 2.422 0.061
ENSG00000157881 E014 240.8311199 0.0016501480 8.588785e-01 9.129479e-01 1 2514002 2514089 88 - 2.329 2.344 0.050
ENSG00000157881 E015 199.8262619 0.0002111813 1.879849e-01 3.111816e-01 1 2514354 2514412 59 - 2.226 2.272 0.155
ENSG00000157881 E016 148.6877849 0.0002661215 2.949988e-01 4.361135e-01 1 2514413 2514432 20 - 2.098 2.142 0.146
ENSG00000157881 E017 163.9798522 0.0004318510 1.934102e-01 3.180669e-01 1 2514433 2514466 34 - 2.135 2.186 0.169
ENSG00000157881 E018 8.7275620 0.0441156247 5.239763e-02 1.134284e-01 1 2515258 2515401 144 - 1.118 0.855 -0.976
ENSG00000157881 E019 279.0150454 0.0001860771 4.487850e-02 9.998116e-02 1 2515562 2515717 156 - 2.361 2.418 0.191
ENSG00000157881 E020 29.4708630 0.0108549196 9.205394e-03 2.679831e-02 1 2515718 2515937 220 - 1.572 1.372 -0.689
ENSG00000157881 E021 186.9999954 0.0024105080 8.359140e-03 2.468765e-02 1 2518164 2518264 101 - 2.149 2.257 0.361
ENSG00000157881 E022 180.4465299 0.0002269843 3.887158e-01 5.327969e-01 1 2518516 2518597 82 - 2.188 2.223 0.117
ENSG00000157881 E023 172.9196309 0.0002343594 2.689164e-01 4.073808e-01 1 2519143 2519203 61 - 2.210 2.188 -0.075
ENSG00000157881 E024 193.8053688 0.0009047745 8.488957e-01 9.062147e-01 1 2519204 2519324 121 - 2.233 2.249 0.052
ENSG00000157881 E025 219.8053532 0.0007793370 8.991055e-01 9.396248e-01 1 2519801 2519954 154 - 2.295 2.301 0.021
ENSG00000157881 E026 197.5719573 0.0002336758 4.839977e-02 1.063292e-01 1 2520322 2520414 93 - 2.283 2.240 -0.146
ENSG00000157881 E027 235.3652700 0.0009739647 3.920633e-03 1.291968e-02 1 2520723 2520833 111 - 2.378 2.307 -0.236
ENSG00000157881 E028 109.1196878 0.0002766724 3.973249e-02 9.052883e-02 1 2520834 2520839 6 - 2.043 1.979 -0.215
ENSG00000157881 E029 185.0100729 0.0002530506 7.414250e-02 1.501700e-01 1 2520840 2520906 67 - 2.254 2.214 -0.134
ENSG00000157881 E030 156.2590773 0.0013349263 7.083013e-02 1.447244e-01 1 2521101 2521144 44 - 2.187 2.135 -0.174
ENSG00000157881 E031 253.5786294 0.0007781075 5.746212e-05 3.188976e-04 1 2521145 2521260 116 - 2.426 2.330 -0.319
ENSG00000157881 E032 185.1368143 0.0002118412 3.724657e-04 1.667553e-03 1 2521261 2521315 55 - 2.286 2.198 -0.294
ENSG00000157881 E033 2.3594686 0.0064146266 3.012848e-02 7.221710e-02 1 2521316 2521366 51 - 0.715 0.374 -1.621
ENSG00000157881 E034 5.5088683 0.0032959037 1.603164e-05 1.016472e-04 1 2521367 2521717 351 - 1.086 0.544 -2.161
ENSG00000157881 E035 193.8308402 0.0003285805 3.475917e-06 2.565959e-05 1 2521718 2521800 83 - 2.324 2.207 -0.390
ENSG00000157881 E036 0.5503986 0.0208948479 1.000000e+00 1.000000e+00 1 2521801 2521941 141 - 0.166 0.163 -0.033
ENSG00000157881 E037 3.3161478 0.0051705640 5.746929e-01 7.004667e-01 1 2525601 2526187 587 - 0.522 0.622 0.451
ENSG00000157881 E038 157.7916544 0.0008774178 3.316489e-05 1.951299e-04 1 2526464 2526602 139 - 2.239 2.116 -0.412