ENSG00000157870

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378427 ENSG00000157870 HEK293_OSMI2_2hA HEK293_TMG_2hB PRXL2B protein_coding protein_coding 21.57799 38.41034 15.04268 1.649875 0.05451917 -1.35185 8.3141523 16.629109 4.748993 1.7799649 0.3056678 -1.8058498 0.36512917 0.43046667 0.3156667 -0.11480000 0.07827254 4.385582e-05 FALSE TRUE
ENST00000419916 ENSG00000157870 HEK293_OSMI2_2hA HEK293_TMG_2hB PRXL2B protein_coding protein_coding 21.57799 38.41034 15.04268 1.649875 0.05451917 -1.35185 6.6363280 9.569941 4.269789 2.4987274 0.6440501 -1.1624771 0.30847917 0.24426667 0.2836000 0.03933333 0.83264179 4.385582e-05 FALSE TRUE
ENST00000464043 ENSG00000157870 HEK293_OSMI2_2hA HEK293_TMG_2hB PRXL2B protein_coding processed_transcript 21.57799 38.41034 15.04268 1.649875 0.05451917 -1.35185 0.6590054 3.188346 0.000000 3.1883461 0.0000000 -8.3211822 0.03844583 0.09076667 0.0000000 -0.09076667 0.93913770 4.385582e-05 FALSE FALSE
ENST00000493183 ENSG00000157870 HEK293_OSMI2_2hA HEK293_TMG_2hB PRXL2B protein_coding processed_transcript 21.57799 38.41034 15.04268 1.649875 0.05451917 -1.35185 1.5270081 1.678948 2.161023 0.7579639 0.2128451 0.3622507 0.06714583 0.04333333 0.1437333 0.10040000 0.02349689 4.385582e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157870 E001 2.8367257 0.0054846122 4.066662e-01 5.502939e-01 1 2586491 2586539 49 + 0.617 0.509 -0.493
ENSG00000157870 E002 4.3062448 0.0383043684 1.080687e-01 2.026678e-01 1 2586540 2586591 52 + 0.829 0.607 -0.920
ENSG00000157870 E003 0.1472490 0.0429504307 1.660117e-01   1 2586750 2586776 27 + 0.183 0.000 -16.126
ENSG00000157870 E004 0.1472490 0.0429504307 1.660117e-01   1 2586777 2586779 3 + 0.183 0.000 -16.126
ENSG00000157870 E005 0.6192988 0.0212585585 4.400017e-02 9.838305e-02 1 2586780 2586795 16 + 0.410 0.080 -2.951
ENSG00000157870 E006 0.7708142 0.0153327607 1.275102e-02 3.532725e-02 1 2586796 2586797 2 + 0.490 0.080 -3.367
ENSG00000157870 E007 10.8278725 0.0016129362 2.066128e-01 3.344855e-01 1 2586798 2586816 19 + 1.078 0.978 -0.366
ENSG00000157870 E008 18.5430449 0.0021197016 9.223668e-02 1.786182e-01 1 2586817 2586832 16 + 1.297 1.188 -0.384
ENSG00000157870 E009 65.1977509 0.0235823484 6.345242e-01 7.489593e-01 1 2586833 2586873 41 + 1.672 1.773 0.340
ENSG00000157870 E010 66.6964122 0.0261481569 6.121409e-01 7.311414e-01 1 2586874 2586876 3 + 1.677 1.784 0.362
ENSG00000157870 E011 90.8519000 0.0173380232 3.476102e-01 4.918140e-01 1 2586877 2586948 72 + 1.794 1.920 0.427
ENSG00000157870 E012 1.3254792 0.0100931595 3.278208e-02 7.737138e-02 1 2587042 2587077 36 + 0.558 0.206 -2.103
ENSG00000157870 E013 1.7286288 0.0112558611 1.129495e-01 2.098476e-01 1 2587078 2587084 7 + 0.558 0.304 -1.364
ENSG00000157870 E014 2.4284665 0.0548494095 8.614317e-02 1.692251e-01 1 2587085 2587090 6 + 0.668 0.387 -1.348
ENSG00000157870 E015 82.0721364 0.0152492208 3.761042e-01 5.204813e-01 1 2587091 2587113 23 + 1.755 1.875 0.403
ENSG00000157870 E016 209.0082187 0.0045209870 2.321982e-01 3.650530e-01 1 2587114 2587295 182 + 2.255 2.251 -0.012
ENSG00000157870 E017 137.0398709 0.0016614494 1.906448e-02 4.947682e-02 1 2587741 2587792 52 + 2.104 2.057 -0.157
ENSG00000157870 E018 3.2566767 0.0867966864 5.907336e-02 1.250351e-01 1 2588336 2588389 54 + 0.794 0.480 -1.373
ENSG00000157870 E019 162.4055353 0.0002870836 2.916473e-04 1.345797e-03 1 2588390 2588453 64 + 2.197 2.126 -0.235
ENSG00000157870 E020 4.1532117 0.0430344144 8.766076e-05 4.640747e-04 1 2588454 2588529 76 + 1.018 0.419 -2.535
ENSG00000157870 E021 13.0523731 0.0014629043 2.437711e-01 3.786099e-01 1 2588530 2588549 20 + 1.148 1.069 -0.284
ENSG00000157870 E022 134.1513000 0.0016502645 2.090290e-01 3.373651e-01 1 2588550 2588593 44 + 2.070 2.064 -0.022
ENSG00000157870 E023 117.1509667 0.0003051368 5.329272e-01 6.652049e-01 1 2588594 2588625 32 + 1.992 2.010 0.060
ENSG00000157870 E024 8.1948571 0.0081022437 3.316734e-06 2.459662e-05 1 2588626 2588921 296 + 1.222 0.720 -1.882
ENSG00000157870 E025 65.3288765 0.0004648531 7.654954e-02 1.539728e-01 1 2588922 2588953 32 + 1.790 1.744 -0.154
ENSG00000157870 E026 91.3277935 0.0003121765 6.177585e-01 7.354937e-01 1 2588954 2588956 3 + 1.879 1.899 0.066
ENSG00000157870 E027 181.9778115 0.0002750135 5.342070e-01 6.662941e-01 1 2588957 2589040 84 + 2.174 2.197 0.075
ENSG00000157870 E028 1594.0523226 0.0051358060 1.574891e-02 4.216960e-02 1 2589410 2591469 2060 + 3.065 3.156 0.302