ENSG00000157851

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288699 ENSG00000157851 HEK293_OSMI2_2hA HEK293_TMG_2hB DPYSL5 protein_coding protein_coding 35.64198 49.57292 31.7411 2.661904 1.390472 -0.6430369 26.910261 38.27854 21.5243079 4.848063 0.5933616 -0.8302756 0.7348708 0.7667000 0.6823667 -0.08433333 6.358928e-01 4.792488e-33 FALSE TRUE
ENST00000401478 ENSG00000157851 HEK293_OSMI2_2hA HEK293_TMG_2hB DPYSL5 protein_coding protein_coding 35.64198 49.57292 31.7411 2.661904 1.390472 -0.6430369 3.913462 11.01121 0.7544901 2.556764 0.3056596 -3.8496413 0.1007667 0.2276333 0.0234000 -0.20423333 1.040346e-03 4.792488e-33 FALSE TRUE
ENST00000434719 ENSG00000157851 HEK293_OSMI2_2hA HEK293_TMG_2hB DPYSL5 protein_coding protein_coding 35.64198 49.57292 31.7411 2.661904 1.390472 -0.6430369 4.473982 0.00000 9.1966407 0.000000 1.7722887 9.8465310 0.1534042 0.0000000 0.2859667 0.28596667 4.792488e-33 4.792488e-33 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157851 E001 0.000000       2 26847747 26847867 121 +      
ENSG00000157851 E002 78.765948 0.0113556680 1.766263e-08 2.080411e-07 2 26848132 26848254 123 + 2.045 1.754 -0.979
ENSG00000157851 E003 5.542549 0.0105014487 3.892991e-01 5.334072e-01 2 26848289 26848359 71 + 0.833 0.776 -0.227
ENSG00000157851 E004 0.000000       2 26848424 26848497 74 +      
ENSG00000157851 E005 0.000000       2 26848508 26848539 32 +      
ENSG00000157851 E006 331.537493 0.0006038672 3.432905e-21 2.517822e-19 2 26898496 26898760 265 + 2.576 2.435 -0.472
ENSG00000157851 E007 376.553299 0.0008210530 4.346829e-18 2.215479e-16 2 26924887 26925045 159 + 2.622 2.498 -0.411
ENSG00000157851 E008 401.111062 0.0017865093 6.164861e-09 7.913236e-08 2 26927253 26927432 180 + 2.622 2.542 -0.269
ENSG00000157851 E009 237.588342 0.0002932522 3.174410e-04 1.450547e-03 2 26928255 26928323 69 + 2.354 2.335 -0.063
ENSG00000157851 E010 196.932764 0.0031106277 6.342548e-03 1.951499e-02 2 26931640 26931684 45 + 2.280 2.252 -0.094
ENSG00000157851 E011 241.067439 0.0031707222 2.976027e-03 1.019179e-02 2 26933258 26933333 76 + 2.370 2.336 -0.115
ENSG00000157851 E012 398.025248 0.0012246427 2.955257e-04 1.361766e-03 2 26934578 26934734 157 + 2.575 2.558 -0.055
ENSG00000157851 E013 13.504168 0.0013796080 1.528926e-03 5.730545e-03 2 26938459 26940030 1572 + 1.266 1.040 -0.809
ENSG00000157851 E014 416.994284 0.0022514169 1.466723e-02 3.974230e-02 2 26940031 26940172 142 + 2.582 2.585 0.011
ENSG00000157851 E015 370.096924 0.0007536660 7.613633e-01 8.452568e-01 2 26941950 26942092 143 + 2.484 2.550 0.220
ENSG00000157851 E016 419.761155 0.0013915612 8.829001e-01 9.290755e-01 2 26942543 26942750 208 + 2.535 2.605 0.234
ENSG00000157851 E017 362.712061 0.0010348305 8.932257e-01 9.357746e-01 2 26944656 26944824 169 + 2.467 2.544 0.256
ENSG00000157851 E018 3667.192158 0.0024993995 1.698646e-16 7.103827e-15 2 26946910 26950351 3442 + 3.384 3.579 0.646