ENSG00000157837

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353487 ENSG00000157837 HEK293_OSMI2_2hA HEK293_TMG_2hB SPPL3 protein_coding protein_coding 48.91908 63.07779 42.44757 2.652193 1.449447 -0.571339 6.122874 8.371663 5.912517 1.9888468 0.9082559 -0.5010260 0.12544583 0.1354333 0.14103333 0.00560000 9.557203e-01 1.374576e-31 FALSE  
ENST00000545209 ENSG00000157837 HEK293_OSMI2_2hA HEK293_TMG_2hB SPPL3 protein_coding retained_intron 48.91908 63.07779 42.44757 2.652193 1.449447 -0.571339 7.488400 10.117901 6.119752 0.7929995 0.9110097 -0.7244345 0.15120833 0.1601667 0.14363333 -0.01653333 7.869826e-01 1.374576e-31 FALSE  
MSTRG.8176.2 ENSG00000157837 HEK293_OSMI2_2hA HEK293_TMG_2hB SPPL3 protein_coding   48.91908 63.07779 42.44757 2.652193 1.449447 -0.571339 8.506588 11.285106 6.987839 2.3440273 0.9773289 -0.6907164 0.17239583 0.1772000 0.16376667 -0.01343333 9.428354e-01 1.374576e-31 TRUE  
MSTRG.8176.3 ENSG00000157837 HEK293_OSMI2_2hA HEK293_TMG_2hB SPPL3 protein_coding   48.91908 63.07779 42.44757 2.652193 1.449447 -0.571339 1.190311 0.000000 3.549279 0.0000000 0.4090935 8.4754410 0.02659167 0.0000000 0.08376667 0.08376667 1.374576e-31 1.374576e-31 FALSE  
MSTRG.8176.4 ENSG00000157837 HEK293_OSMI2_2hA HEK293_TMG_2hB SPPL3 protein_coding   48.91908 63.07779 42.44757 2.652193 1.449447 -0.571339 24.771025 32.998572 18.969160 2.1245983 0.8191906 -0.7984246 0.50712083 0.5221000 0.44666667 -0.07543333 1.819080e-02 1.374576e-31 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157837 E001 7.2563923 0.0833532229 9.933856e-01 1.000000e+00 12 120762510 120762590 81 - 0.892 0.913 0.080
ENSG00000157837 E002 23.1634864 0.0693984552 8.665161e-01 9.180630e-01 12 120762591 120762703 113 - 1.338 1.374 0.126
ENSG00000157837 E003 42.5585090 0.0422118781 9.345532e-01 9.627894e-01 12 120762704 120762836 133 - 1.616 1.617 0.002
ENSG00000157837 E004 728.9032294 0.0042149011 7.613046e-03 2.280663e-02 12 120762837 120764464 1628 - 2.777 2.861 0.280
ENSG00000157837 E005 329.5475781 0.0007949837 1.054719e-07 1.067037e-06 12 120764465 120764614 150 - 2.400 2.527 0.423
ENSG00000157837 E006 782.6963946 0.0004486451 1.675241e-06 1.325022e-05 12 120764615 120764890 276 - 2.815 2.887 0.239
ENSG00000157837 E007 588.2479576 0.0001541947 1.406095e-04 7.061115e-04 12 120764891 120765070 180 - 2.703 2.759 0.185
ENSG00000157837 E008 345.4382964 0.0001358581 4.881435e-02 1.070513e-01 12 120766263 120766372 110 - 2.487 2.522 0.117
ENSG00000157837 E009 544.4521495 0.0001861177 9.712755e-01 9.860681e-01 12 120767394 120767593 200 - 2.711 2.705 -0.017
ENSG00000157837 E010 397.4969213 0.0012693859 9.618850e-01 9.799585e-01 12 120768325 120768437 113 - 2.572 2.569 -0.009
ENSG00000157837 E011 297.1438455 0.0004169493 9.690698e-01 9.846519e-01 12 120768438 120768488 51 - 2.446 2.442 -0.013
ENSG00000157837 E012 0.6955713 0.0164597344 6.085448e-01 7.282587e-01 12 120768489 120768631 143 - 0.267 0.176 -0.768
ENSG00000157837 E013 192.0181950 0.0002306883 1.940094e-01 3.188246e-01 12 120768953 120768957 5 - 2.281 2.241 -0.133
ENSG00000157837 E014 312.1963397 0.0004696162 3.544490e-02 8.250719e-02 12 120768958 120768996 39 - 2.500 2.447 -0.174
ENSG00000157837 E015 339.6133703 0.0001762761 1.670609e-01 2.843746e-01 12 120768997 120769059 63 - 2.525 2.492 -0.109
ENSG00000157837 E016 4.8681728 0.0248774105 2.417028e-01 3.761963e-01 12 120769060 120770137 1078 - 0.868 0.695 -0.690
ENSG00000157837 E017 261.0417941 0.0001951732 3.731905e-01 5.176402e-01 12 120782655 120782689 35 - 2.408 2.382 -0.084
ENSG00000157837 E018 328.0728164 0.0021058787 1.450171e-01 2.548544e-01 12 120782690 120782767 78 - 2.520 2.474 -0.154
ENSG00000157837 E019 361.0022196 0.0003811051 3.701915e-02 8.550556e-02 12 120783674 120783752 79 - 2.562 2.514 -0.160
ENSG00000157837 E020 0.7739347 0.0148380512 3.079345e-01 4.501746e-01 12 120784203 120784473 271 - 0.357 0.175 -1.357
ENSG00000157837 E021 391.8698481 0.0017036453 1.666014e-02 4.419185e-02 12 120784474 120784593 120 - 2.609 2.542 -0.223
ENSG00000157837 E022 252.7705301 0.0019221523 1.882989e-02 4.895720e-02 12 120791469 120791557 89 - 2.425 2.348 -0.255
ENSG00000157837 E023 0.3299976 0.0274424043 3.819672e-01   12 120791558 120791945 388 - 0.000 0.175 10.488
ENSG00000157837 E024 163.8724579 0.0095333051 1.321377e-02 3.640964e-02 12 120810809 120810886 78 - 2.274 2.138 -0.455
ENSG00000157837 E025 0.0000000       12 120811199 120811442 244 -      
ENSG00000157837 E026 0.0000000       12 120835439 120835657 219 -      
ENSG00000157837 E027 1.3640716 0.0371831442 2.362613e-02 5.904023e-02 12 120866519 120866556 38 - 0.000 0.440 12.242
ENSG00000157837 E028 1.0393871 0.0271047370 5.368081e-01 6.685161e-01 12 120901878 120901948 71 - 0.357 0.243 -0.768
ENSG00000157837 E029 0.0000000       12 120903316 120903439 124 -      
ENSG00000157837 E030 0.2934659 0.0292881293 7.021791e-01   12 120903440 120903494 55 - 0.154 0.096 -0.773
ENSG00000157837 E031 155.1405320 0.0162658768 2.993686e-11 5.767770e-10 12 120903845 120904358 514 - 2.412 1.961 -1.508