ENSG00000157833

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000401533 ENSG00000157833 HEK293_OSMI2_2hA HEK293_TMG_2hB GAREM2 protein_coding protein_coding 8.850223 15.8648 6.805525 1.00114 0.3063043 -1.219842 4.0211207 5.562020 4.4082788 0.8624058 0.01440942 -0.3347158 0.50416667 0.3491000 0.6501333 0.30103333 0.0003807972 0.0003807972 FALSE TRUE
ENST00000496070 ENSG00000157833 HEK293_OSMI2_2hA HEK293_TMG_2hB GAREM2 protein_coding processed_transcript 8.850223 15.8648 6.805525 1.00114 0.3063043 -1.219842 0.8265908 2.397803 0.2766545 0.6045014 0.16614834 -3.0703325 0.06533333 0.1484333 0.0387000 -0.10973333 0.2106325683 0.0003807972 FALSE FALSE
MSTRG.18089.3 ENSG00000157833 HEK293_OSMI2_2hA HEK293_TMG_2hB GAREM2 protein_coding   8.850223 15.8648 6.805525 1.00114 0.3063043 -1.219842 1.2564522 1.817045 0.6660242 0.3199137 0.18901666 -1.4343657 0.13800000 0.1130333 0.1006000 -0.01243333 0.8671004612 0.0003807972 FALSE TRUE
MSTRG.18089.5 ENSG00000157833 HEK293_OSMI2_2hA HEK293_TMG_2hB GAREM2 protein_coding   8.850223 15.8648 6.805525 1.00114 0.3063043 -1.219842 2.6371966 5.950692 1.3534790 0.4380017 0.29780829 -2.1281875 0.27883333 0.3805667 0.1959667 -0.18460000 0.0437498348 0.0003807972 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157833 E001 0.8794552 0.0416354558 1.094098e-03 4.284056e-03 2 26173088 26173098 11 + 0.560 0.000 -11.764
ENSG00000157833 E002 2.0920165 0.0082874183 6.619482e-06 4.583986e-05 2 26173099 26173115 17 + 0.826 0.094 -4.562
ENSG00000157833 E003 33.1728716 0.0045193726 3.163981e-02 7.515036e-02 2 26173116 26173332 217 + 1.583 1.450 -0.458
ENSG00000157833 E004 65.8637964 0.0029136198 8.768886e-02 1.716209e-01 2 26176344 26176484 141 + 1.839 1.766 -0.246
ENSG00000157833 E005 12.5107638 0.0054799040 1.999762e-03 7.225252e-03 2 26176770 26176969 200 + 0.826 1.189 1.343
ENSG00000157833 E006 0.7771569 0.0143392507 4.114348e-02 9.314997e-02 2 26180716 26182493 1778 + 0.440 0.094 -2.862
ENSG00000157833 E007 62.5162271 0.0004800910 5.822383e-03 1.814334e-02 2 26182967 26183097 131 + 1.842 1.728 -0.385
ENSG00000157833 E008 118.8602918 0.0051816455 6.885791e-07 5.921168e-06 2 26184233 26185231 999 + 2.170 1.967 -0.679
ENSG00000157833 E009 23.4155669 0.0086505158 7.683538e-01 8.503198e-01 2 26185232 26185276 45 + 1.317 1.356 0.137
ENSG00000157833 E010 40.9722140 0.0005888971 6.175425e-02 1.295774e-01 2 26186189 26186358 170 + 1.495 1.617 0.415
ENSG00000157833 E011 40.7772735 0.0006059972 1.614631e-01 2.770114e-01 2 26187231 26187315 85 + 1.519 1.611 0.316
ENSG00000157833 E012 92.6766266 0.0003581247 2.530500e-02 6.250351e-02 2 26187316 26187714 399 + 1.863 1.961 0.329
ENSG00000157833 E013 105.1765224 0.0003923175 9.956941e-01 1.000000e+00 2 26187715 26188068 354 + 1.979 1.990 0.036
ENSG00000157833 E014 103.4541147 0.0003138292 8.229858e-01 8.884139e-01 2 26188069 26188291 223 + 1.969 1.987 0.062
ENSG00000157833 E015 415.9524225 0.0057864133 4.029354e-03 1.322412e-02 2 26188292 26189663 1372 + 2.519 2.615 0.319
ENSG00000157833 E016 2.7928984 0.0056862638 2.531068e-04 1.188183e-03 2 26190479 26190579 101 + 0.854 0.294 -2.669