ENSG00000157800

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326232 ENSG00000157800 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC37A3 protein_coding protein_coding 31.89458 25.07532 32.47313 2.39839 0.5057526 0.3728475 14.539945 7.491004 17.9893591 0.7100888 0.62621370 1.2627898 0.43723750 0.30116667 0.553666667 0.25250000 3.588186e-08 3.366595e-12 FALSE TRUE
ENST00000340308 ENSG00000157800 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC37A3 protein_coding protein_coding 31.89458 25.07532 32.47313 2.39839 0.5057526 0.3728475 3.838056 2.117009 3.9805444 0.7469394 0.68619619 0.9077593 0.11429167 0.08146667 0.122900000 0.04143333 5.999743e-01 3.366595e-12 FALSE TRUE
ENST00000469636 ENSG00000157800 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC37A3 protein_coding protein_coding 31.89458 25.07532 32.47313 2.39839 0.5057526 0.3728475 2.051071 4.272686 0.1359795 0.6173255 0.08332811 -4.8746778 0.07929167 0.17353333 0.004166667 -0.16936667 5.938091e-07 3.366595e-12   FALSE
MSTRG.30811.29 ENSG00000157800 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC37A3 protein_coding   31.89458 25.07532 32.47313 2.39839 0.5057526 0.3728475 4.799922 7.529378 2.0521833 1.0113307 0.30863372 -1.8702730 0.16596667 0.29923333 0.062933333 -0.23630000 3.366595e-12 3.366595e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157800 E001 1.0726991 0.0117265251 6.062192e-01 7.264205e-01 7 140293693 140295352 1660 - 0.351 0.267 -0.548
ENSG00000157800 E002 0.4815130 0.0205163556 3.205702e-01 4.637134e-01 7 140295985 140296137 153 - 0.097 0.267 1.773
ENSG00000157800 E003 0.4502799 0.0288924552 1.974228e-01 3.230029e-01 7 140297300 140297523 224 - 0.242 0.000 -11.605
ENSG00000157800 E004 0.8082883 0.0154207140 3.849106e-03 1.271804e-02 7 140333752 140333753 2 - 0.000 0.495 12.983
ENSG00000157800 E005 27.4239464 0.0100883286 1.013841e-03 4.006533e-03 7 140333754 140333790 37 - 1.310 1.589 0.961
ENSG00000157800 E006 604.3422426 0.0024145208 1.891919e-09 2.661457e-08 7 140333791 140334869 1079 - 2.703 2.866 0.543
ENSG00000157800 E007 108.9100843 0.0004817313 2.640848e-02 6.476385e-02 7 140334870 140334890 21 - 1.999 2.096 0.324
ENSG00000157800 E008 164.7207274 0.0003088185 8.245385e-03 2.440610e-02 7 140334891 140334988 98 - 2.177 2.270 0.312
ENSG00000157800 E009 167.8286709 0.0013431486 2.226841e-01 3.535872e-01 7 140334989 140335104 116 - 2.199 2.256 0.190
ENSG00000157800 E010 185.0271942 0.0030586623 7.144275e-01 8.106452e-01 7 140335105 140335289 185 - 2.252 2.279 0.089
ENSG00000157800 E011 79.5333265 0.0038626738 5.172331e-01 6.516564e-01 7 140335290 140335320 31 - 1.908 1.890 -0.061
ENSG00000157800 E012 132.7670445 0.0006086730 2.715679e-01 4.103405e-01 7 140335321 140335436 116 - 2.130 2.112 -0.060
ENSG00000157800 E013 75.6930712 0.0003522724 3.499027e-01 4.941004e-01 7 140335437 140335439 3 - 1.890 1.870 -0.066
ENSG00000157800 E014 74.8640703 0.0003408137 2.180683e-01 3.480843e-01 7 140335440 140335454 15 - 1.890 1.858 -0.109
ENSG00000157800 E015 71.4576147 0.0003743567 2.202120e-01 3.506792e-01 7 140335455 140335471 17 - 1.870 1.837 -0.113
ENSG00000157800 E016 79.0502261 0.0003719140 2.599486e-01 3.974375e-01 7 140335472 140335504 33 - 1.912 1.885 -0.090
ENSG00000157800 E017 103.9949519 0.0006198997 1.263670e-02 3.505460e-02 7 140337284 140337349 66 - 2.048 1.976 -0.243
ENSG00000157800 E018 5.0811633 0.1407942642 7.862523e-01 8.631001e-01 7 140337350 140337825 476 - 0.793 0.776 -0.067
ENSG00000157800 E019 107.0609086 0.0022988883 5.972199e-01 7.190163e-01 7 140343412 140343563 152 - 2.032 2.028 -0.014
ENSG00000157800 E020 4.7058150 0.0890421071 5.510268e-01 6.805611e-01 7 140343564 140344086 523 - 0.795 0.683 -0.457
ENSG00000157800 E021 60.6563684 0.0069502216 8.735886e-01 9.227604e-01 7 140345216 140345263 48 - 1.783 1.790 0.023
ENSG00000157800 E022 76.7099440 0.0043974028 2.555546e-01 3.924583e-01 7 140345869 140345970 102 - 1.902 1.860 -0.143
ENSG00000157800 E023 1.0466748 0.2616439962 9.310350e-01 9.605700e-01 7 140348458 140348625 168 - 0.301 0.349 0.301
ENSG00000157800 E024 139.9087856 0.0002454554 3.430613e-03 1.152564e-02 7 140348626 140348767 142 - 2.173 2.102 -0.238
ENSG00000157800 E025 128.9533917 0.0002393689 3.947707e-09 5.241302e-08 7 140351273 140351360 88 - 2.174 2.001 -0.581
ENSG00000157800 E026 120.6989195 0.0002937137 8.303997e-04 3.367729e-03 7 140351361 140351430 70 - 2.117 2.024 -0.311
ENSG00000157800 E027 88.8204744 0.0003478977 1.768174e-03 6.498065e-03 7 140351431 140351451 21 - 1.988 1.885 -0.346
ENSG00000157800 E028 6.5255856 0.0363955481 1.764987e-01 2.966969e-01 7 140351452 140351519 68 - 0.776 0.978 0.774
ENSG00000157800 E029 12.0488089 0.0743409802 4.952535e-01 6.320858e-01 7 140351520 140351788 269 - 1.059 1.161 0.370
ENSG00000157800 E030 5.9565633 0.1047824154 9.622738e-01 9.802055e-01 7 140351789 140351875 87 - 0.827 0.827 0.002
ENSG00000157800 E031 2.1984780 0.0660865454 2.628751e-01 4.006959e-01 7 140351876 140351888 13 - 0.572 0.359 -1.089
ENSG00000157800 E032 4.2655143 0.0060369268 6.686131e-02 1.381543e-01 7 140351889 140351969 81 - 0.811 0.551 -1.100
ENSG00000157800 E033 126.3977767 0.0002496021 8.680928e-08 8.918524e-07 7 140352062 140352146 85 - 2.159 2.001 -0.529
ENSG00000157800 E034 4.5928839 0.0035391396 9.202491e-02 1.782711e-01 7 140352147 140352181 35 - 0.828 0.600 -0.942
ENSG00000157800 E035 121.9845690 0.0004429026 1.725991e-07 1.675379e-06 7 140355668 140355764 97 - 2.148 1.989 -0.532
ENSG00000157800 E036 136.1938668 0.0002868476 2.900625e-09 3.948797e-08 7 140358640 140358785 146 - 2.198 2.027 -0.571
ENSG00000157800 E037 86.9788815 0.0002991050 6.738365e-04 2.803046e-03 7 140364408 140364458 51 - 1.985 1.870 -0.385
ENSG00000157800 E038 94.1802355 0.0013619432 2.192091e-05 1.346274e-04 7 140364459 140364491 33 - 2.033 1.875 -0.533
ENSG00000157800 E039 113.7154112 0.0007865226 1.533141e-06 1.223064e-05 7 140369590 140369682 93 - 2.117 1.961 -0.522
ENSG00000157800 E040 28.7280844 0.0089534486 1.033042e-17 5.067494e-16 7 140375533 140375654 122 - 1.029 1.756 2.531
ENSG00000157800 E041 6.7063705 0.0024654432 8.758608e-03 2.568086e-02 7 140379214 140379258 45 - 0.718 1.050 1.271
ENSG00000157800 E042 6.7932521 0.0025129812 3.371614e-03 1.135481e-02 7 140379259 140379307 49 - 0.697 1.066 1.418
ENSG00000157800 E043 7.5554554 0.0023352000 3.533912e-05 2.063944e-04 7 140379308 140379471 164 - 0.652 1.152 1.921
ENSG00000157800 E044 4.0587386 0.0042450862 4.072545e-01 5.508421e-01 7 140379878 140380281 404 - 0.652 0.785 0.550
ENSG00000157800 E045 166.0919966 0.0002941903 1.363318e-03 5.187525e-03 7 140380282 140380390 109 - 2.175 2.283 0.362
ENSG00000157800 E046 115.3271097 0.0003037762 6.005489e-04 2.535144e-03 7 140382438 140382482 45 - 2.003 2.136 0.444
ENSG00000157800 E047 129.5408172 0.0002866121 7.858414e-06 5.347340e-05 7 140382483 140382596 114 - 2.041 2.200 0.530
ENSG00000157800 E048 60.4605058 0.0024654379 1.872798e-02 4.873906e-02 7 140398416 140398550 135 - 1.724 1.859 0.456
ENSG00000157800 E049 0.0000000       7 140398599 140398681 83 -      
ENSG00000157800 E050 0.0000000       7 140400336 140402601 2266 -      
ENSG00000157800 E051 0.0000000       7 140402602 140402822 221 -      
ENSG00000157800 E052 0.0000000       7 140404185 140404433 249 -