ENSG00000157796

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399820 ENSG00000157796 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR19 protein_coding protein_coding 7.200465 2.954119 8.878073 0.348673 0.1743285 1.584268 3.4052460 0.5036685 5.0795486 0.2461478 0.1480732 3.3086281 0.41377083 0.1752333 0.57210000 0.3968667 0.007075158 0.005353112 FALSE TRUE
ENST00000506869 ENSG00000157796 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR19 protein_coding nonsense_mediated_decay 7.200465 2.954119 8.878073 0.348673 0.1743285 1.584268 0.1906528 0.5287246 0.0000000 0.3001569 0.0000000 -5.7514760 0.04351667 0.1926333 0.00000000 -0.1926333 0.075990348 0.005353112 FALSE TRUE
ENST00000512534 ENSG00000157796 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR19 protein_coding retained_intron 7.200465 2.954119 8.878073 0.348673 0.1743285 1.584268 1.3394348 0.7336133 1.4092003 0.1138805 0.1088175 0.9324538 0.20533333 0.2614333 0.15933333 -0.1021000 0.425474618 0.005353112 FALSE FALSE
ENST00000512588 ENSG00000157796 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR19 protein_coding retained_intron 7.200465 2.954119 8.878073 0.348673 0.1743285 1.584268 0.8282506 0.9754962 0.3810913 0.5311441 0.2734842 -1.3333447 0.17479583 0.2988000 0.04296667 -0.2558333 0.550673817 0.005353112 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157796 E001 1.9176990 0.0074086543 1.619618e-01 2.776783e-01 4 39182504 39182523 20 + 0.487 0.208 -1.751
ENSG00000157796 E002 2.2175076 0.0066596325 3.826944e-01 5.268727e-01 4 39182524 39182528 5 + 0.511 0.348 -0.867
ENSG00000157796 E003 2.2175076 0.0066596325 3.826944e-01 5.268727e-01 4 39182529 39182530 2 + 0.511 0.348 -0.867
ENSG00000157796 E004 8.3769870 0.0019835376 2.812602e-01 4.211501e-01 4 39182531 39182547 17 + 0.951 0.815 -0.519
ENSG00000157796 E005 11.4245278 0.0018608533 6.397769e-01 7.531087e-01 4 39182548 39182563 16 + 1.055 1.009 -0.166
ENSG00000157796 E006 17.3261189 0.0024397194 9.171245e-02 1.778076e-01 4 39185726 39185817 92 + 1.244 1.081 -0.581
ENSG00000157796 E007 16.2786795 0.0011361748 6.544190e-03 2.003907e-02 4 39186539 39186604 66 + 1.240 0.954 -1.035
ENSG00000157796 E008 19.5344295 0.0010019692 8.888463e-03 2.600205e-02 4 39189656 39189781 126 + 1.307 1.059 -0.886
ENSG00000157796 E009 16.1645672 0.0119487573 1.752403e-04 8.579373e-04 4 39194544 39194659 116 + 1.260 0.772 -1.808
ENSG00000157796 E010 0.0000000       4 39194660 39194781 122 +      
ENSG00000157796 E011 19.8402753 0.0492260607 2.263007e-01 3.579616e-01 4 39199478 39199593 116 + 1.295 1.129 -0.587
ENSG00000157796 E012 17.0830462 0.0043370083 5.062919e-01 6.419444e-01 4 39203642 39203722 81 + 1.175 1.246 0.253
ENSG00000157796 E013 0.0000000       4 39203723 39203727 5 +      
ENSG00000157796 E014 19.3074988 0.0321372859 3.203023e-01 4.634011e-01 4 39205154 39205266 113 + 1.209 1.334 0.439
ENSG00000157796 E015 25.6388600 0.0007242531 3.505839e-01 4.947673e-01 4 39205563 39205736 174 + 1.382 1.315 -0.232
ENSG00000157796 E016 0.0000000       4 39205737 39206115 379 +      
ENSG00000157796 E017 18.6905453 0.0009915908 1.847129e-01 3.071151e-01 4 39214601 39214671 71 + 1.261 1.143 -0.417
ENSG00000157796 E018 16.7061758 0.0010595446 6.373205e-01 7.512348e-01 4 39215841 39215881 41 + 1.199 1.162 -0.132
ENSG00000157796 E019 28.7021776 0.0007212220 9.906716e-01 9.983285e-01 4 39215882 39216013 132 + 1.409 1.418 0.032
ENSG00000157796 E020 26.1699993 0.0007459132 7.645270e-01 8.475770e-01 4 39216096 39216210 115 + 1.366 1.397 0.109
ENSG00000157796 E021 22.4461941 0.0016102210 1.937597e-01 3.185062e-01 4 39217134 39217240 107 + 1.336 1.230 -0.371
ENSG00000157796 E022 9.6640737 0.0182445650 1.598505e-01 2.749144e-01 4 39217983 39217986 4 + 1.013 0.816 -0.746
ENSG00000157796 E023 21.4801415 0.0019442465 1.953025e-02 5.047883e-02 4 39217987 39218105 119 + 1.336 1.124 -0.750
ENSG00000157796 E024 2.3261472 0.0063997401 3.837288e-01 5.279284e-01 4 39218106 39219133 1028 + 0.511 0.348 -0.865
ENSG00000157796 E025 21.8780325 0.0008984249 6.262481e-04 2.629393e-03 4 39224884 39225033 150 + 1.360 1.035 -1.154
ENSG00000157796 E026 26.6619939 0.0007765904 4.727583e-02 1.043282e-01 4 39228210 39228357 148 + 1.415 1.260 -0.538
ENSG00000157796 E027 15.2509773 0.0012366676 6.245986e-01 7.408763e-01 4 39228486 39228530 45 + 1.165 1.124 -0.147
ENSG00000157796 E028 13.8087396 0.0015214107 4.734289e-01 6.123668e-01 4 39228531 39228554 24 + 1.127 1.059 -0.248
ENSG00000157796 E029 12.4758840 0.0016817355 6.305805e-01 7.457412e-01 4 39228555 39228557 3 + 1.080 1.035 -0.165
ENSG00000157796 E030 23.9455529 0.0008238481 2.020542e-01 3.287632e-01 4 39228558 39228690 133 + 1.360 1.260 -0.346
ENSG00000157796 E031 23.6393650 0.0008451958 2.159324e-01 3.455251e-01 4 39231797 39231956 160 + 1.356 1.260 -0.336
ENSG00000157796 E032 13.1432289 0.0013410890 6.582486e-01 7.674328e-01 4 39232162 39232189 28 + 1.098 1.059 -0.144
ENSG00000157796 E033 20.9523018 0.0008792096 4.741081e-02 1.045652e-01 4 39232190 39232272 83 + 1.318 1.143 -0.618
ENSG00000157796 E034 0.8804994 0.0196941418 7.468514e-01 8.345105e-01 4 39232273 39232308 36 + 0.270 0.208 -0.489
ENSG00000157796 E035 10.2578142 0.0132590594 1.846376e-01 3.070276e-01 4 39234766 39234766 1 + 1.028 0.855 -0.647
ENSG00000157796 E036 22.9251543 0.0008378970 6.840535e-02 1.407307e-01 4 39234767 39234875 109 + 1.350 1.197 -0.534
ENSG00000157796 E037 0.0000000       4 39237680 39237994 315 +      
ENSG00000157796 E038 18.8367778 0.0010058532 5.982436e-02 1.263142e-01 4 39240277 39240334 58 + 1.277 1.103 -0.618
ENSG00000157796 E039 21.2713089 0.0009822469 3.533659e-01 4.976037e-01 4 39244248 39244388 141 + 1.304 1.230 -0.259
ENSG00000157796 E040 19.9198900 0.0010526694 6.311928e-01 7.462567e-01 4 39244470 39244552 83 + 1.265 1.230 -0.122
ENSG00000157796 E041 23.6163825 0.0007947329 4.532559e-01 5.939995e-01 4 39245369 39245452 84 + 1.343 1.289 -0.189
ENSG00000157796 E042 32.3219461 0.0006546018 1.584760e-01 2.730934e-01 4 39253146 39253292 147 + 1.481 1.387 -0.326
ENSG00000157796 E043 27.6102889 0.0039203375 4.667491e-01 6.063014e-01 4 39253906 39254030 125 + 1.403 1.354 -0.172
ENSG00000157796 E044 33.2730836 0.0006869744 6.149723e-01 7.333610e-01 4 39255848 39255960 113 + 1.459 1.502 0.148
ENSG00000157796 E045 26.6588527 0.0028088426 3.437046e-01 4.877621e-01 4 39257486 39257554 69 + 1.397 1.328 -0.239
ENSG00000157796 E046 21.0366740 0.0485858752 5.825585e-01 7.069040e-01 4 39266063 39266140 78 + 1.303 1.240 -0.222
ENSG00000157796 E047 19.7933311 0.0426976852 6.440579e-01 7.564636e-01 4 39267995 39268091 97 + 1.245 1.320 0.265
ENSG00000157796 E048 19.2481775 0.0009934090 3.520622e-01 4.963027e-01 4 39269976 39270052 77 + 1.227 1.315 0.311
ENSG00000157796 E049 15.5279692 0.0011833849 9.534347e-01 9.748636e-01 4 39270053 39270100 48 + 1.160 1.162 0.008
ENSG00000157796 E050 19.8583277 0.0009639410 5.622837e-01 6.899289e-01 4 39272980 39273061 82 + 1.244 1.302 0.204
ENSG00000157796 E051 52.7444154 0.0040348911 5.324093e-07 4.684999e-06 4 39273062 39274807 1746 + 1.570 1.868 1.008
ENSG00000157796 E052 37.2416026 0.0025436546 3.469314e-02 8.106105e-02 4 39274808 39274958 151 + 1.479 1.626 0.502
ENSG00000157796 E053 1.2608349 0.0108647759 4.856985e-01 6.235437e-01 4 39274959 39275339 381 + 0.344 0.208 -0.972
ENSG00000157796 E054 0.9275265 0.0147078783 5.387048e-01 6.701117e-01 4 39276962 39276963 2 + 0.228 0.348 0.833
ENSG00000157796 E055 1.9196972 0.2278755781 1.318155e-01 2.366481e-01 4 39276964 39277019 56 + 0.309 0.667 1.813
ENSG00000157796 E056 38.4242429 0.0006032910 5.892345e-06 4.128097e-05 4 39277020 39277143 124 + 1.451 1.726 0.940
ENSG00000157796 E057 0.1451727 0.0426762711 1.000000e+00   4 39277144 39277158 15 + 0.069 0.000 -8.256
ENSG00000157796 E058 33.5648893 0.0006495327 5.617005e-06 3.952621e-05 4 39278131 39278207 77 + 1.385 1.679 1.005
ENSG00000157796 E059 0.4439371 0.0215743828 5.164594e-01 6.510332e-01 4 39278271 39278538 268 + 0.181 0.000 -9.842
ENSG00000157796 E060 37.8738840 0.0218735481 8.799851e-03 2.578343e-02 4 39278539 39278663 125 + 1.451 1.708 0.877
ENSG00000157796 E061 37.6961265 0.0041392979 1.464022e-06 1.173441e-05 4 39285487 39285810 324 + 1.423 1.745 1.098