ENSG00000157764

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000469930 ENSG00000157764 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAF protein_coding protein_coding 5.215004 2.916844 6.51645 0.1262081 0.1386552 1.156952 0.4993367 0.6068687 0.4864825 0.01587988 0.009482213 -0.3132207 0.11699583 0.2085667 0.07470000 -0.1338667 1.970692e-04 4.118809e-09 FALSE TRUE
ENST00000496384 ENSG00000157764 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAF protein_coding protein_coding 5.215004 2.916844 6.51645 0.1262081 0.1386552 1.156952 2.4870614 1.0838603 3.5663293 0.02220976 0.093129485 1.7090510 0.47384583 0.3735333 0.54823333 0.1747000 1.631195e-02 4.118809e-09 FALSE TRUE
ENST00000642228 ENSG00000157764 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAF protein_coding nonsense_mediated_decay 5.215004 2.916844 6.51645 0.1262081 0.1386552 1.156952 0.3039178 0.4815334 0.1728956 0.27114331 0.087469906 -1.4262692 0.06947917 0.1640667 0.02616667 -0.1379000 6.072994e-01 4.118809e-09 FALSE TRUE
ENST00000647434 ENSG00000157764 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAF protein_coding nonsense_mediated_decay 5.215004 2.916844 6.51645 0.1262081 0.1386552 1.156952 0.7784598 0.6102179 0.6723394 0.30668412 0.148010689 0.1377145 0.14559583 0.2077333 0.10240000 -0.1053333 9.253806e-01 4.118809e-09 TRUE TRUE
MSTRG.30832.5 ENSG00000157764 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAF protein_coding   5.215004 2.916844 6.51645 0.1262081 0.1386552 1.156952 0.7502155 0.0000000 1.0617273 0.00000000 0.138872323 6.7437941 0.11971667 0.0000000 0.16350000 0.1635000 4.118809e-09 4.118809e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157764 E001 0.1482932 0.0409092879 2.005058e-01   7 140719327 140719336 10 - 0.000 0.172 10.151
ENSG00000157764 E002 341.3043644 0.0064433853 5.586865e-04 2.379958e-03 7 140719337 140725144 5808 - 2.560 2.411 -0.497
ENSG00000157764 E003 17.3531032 0.0010673639 6.364905e-01 7.505086e-01 7 140725145 140725324 180 - 1.243 1.257 0.047
ENSG00000157764 E004 7.2784423 0.0089123519 6.195291e-03 1.912900e-02 7 140725325 140725429 105 - 0.778 1.086 1.162
ENSG00000157764 E005 81.6664489 0.0030204193 2.822612e-01 4.222317e-01 7 140725430 140726516 1087 - 1.927 1.848 -0.265
ENSG00000157764 E006 1.4714701 0.3450489659 9.584057e-01 9.779179e-01 7 140730665 140732562 1898 - 0.400 0.380 -0.116
ENSG00000157764 E007 6.7578344 0.0025033298 9.114075e-01 9.477540e-01 7 140732563 140734313 1751 - 0.876 0.866 -0.040
ENSG00000157764 E008 2.9453431 0.0820469046 5.962063e-01 7.181793e-01 7 140734314 140734485 172 - 0.556 0.641 0.377
ENSG00000157764 E009 1.3963409 0.0556283119 3.867823e-01 5.309522e-01 7 140734486 140734486 1 - 0.319 0.468 0.838
ENSG00000157764 E010 1.9906475 0.0302917826 5.262129e-01 6.594698e-01 7 140734487 140734520 34 - 0.437 0.535 0.482
ENSG00000157764 E011 2.8513621 0.0322349537 3.857475e-02 8.840878e-02 7 140734521 140734557 37 - 0.437 0.766 1.477
ENSG00000157764 E012 5.6545749 0.0090288961 2.696998e-05 1.622232e-04 7 140734558 140734596 39 - 0.557 1.085 2.099
ENSG00000157764 E013 5.9103857 0.0282918431 6.466899e-08 6.815011e-07 7 140734597 140734616 20 - 0.402 1.174 3.196
ENSG00000157764 E014 31.6200356 0.0007230319 1.345117e-06 1.086642e-05 7 140734617 140734770 154 - 1.381 1.652 0.930
ENSG00000157764 E015 30.0389371 0.0007057203 1.950109e-03 7.072019e-03 7 140739812 140739946 135 - 1.404 1.575 0.588
ENSG00000157764 E016 0.0000000       7 140739947 140741717 1771 -      
ENSG00000157764 E017 0.2998086 0.0287408901 5.230494e-01   7 140747366 140747447 82 - 0.085 0.172 1.164
ENSG00000157764 E018 0.1472490 0.0428491989 1.000000e+00   7 140748932 140749052 121 - 0.085 0.000 -11.632
ENSG00000157764 E019 25.6271743 0.0008067646 5.088650e-02 1.107494e-01 7 140749287 140749418 132 - 1.365 1.474 0.377
ENSG00000157764 E020 23.4565935 0.0008584657 6.117087e-03 1.891467e-02 7 140753275 140753393 119 - 1.304 1.474 0.589
ENSG00000157764 E021 0.9244060 0.0133290483 4.777505e-01 6.162665e-01 7 140753394 140754186 793 - 0.319 0.172 -1.155
ENSG00000157764 E022 19.1087441 0.0010343995 7.956984e-02 1.588601e-01 7 140754187 140754233 47 - 1.238 1.351 0.397
ENSG00000157764 E023 0.0000000       7 140758100 140758290 191 -      
ENSG00000157764 E024 0.1451727 0.0430457753 1.000000e+00   7 140773267 140773406 140 - 0.085 0.000 -11.631
ENSG00000157764 E025 36.2115004 0.0005739381 2.980318e-01 4.394246e-01 7 140776912 140777088 177 - 1.540 1.575 0.119
ENSG00000157764 E026 28.3875051 0.0007330010 5.589375e-01 6.870959e-01 7 140777991 140778075 85 - 1.472 1.404 -0.234
ENSG00000157764 E027 0.0000000       7 140779807 140779928 122 -      
ENSG00000157764 E028 0.1515154 0.0430306008 1.000000e+00   7 140780359 140781575 1217 - 0.085 0.000 -11.632
ENSG00000157764 E029 40.2109135 0.0005904744 4.125007e-01 5.560562e-01 7 140781576 140781693 118 - 1.622 1.546 -0.259
ENSG00000157764 E030 38.4160740 0.0005878001 8.055241e-01 8.763553e-01 7 140783021 140783157 137 - 1.594 1.551 -0.144
ENSG00000157764 E031 0.0000000       7 140783158 140783464 307 -      
ENSG00000157764 E032 0.3030308 0.3432361933 6.797116e-01   7 140785689 140785808 120 - 0.157 0.000 -11.809
ENSG00000157764 E033 24.5453127 0.0008014961 9.826944e-01 9.932536e-01 7 140787548 140787584 37 - 1.404 1.378 -0.087
ENSG00000157764 E034 36.2772565 0.0005532619 8.103980e-01 8.796774e-01 7 140794308 140794415 108 - 1.559 1.546 -0.044
ENSG00000157764 E035 23.9151809 0.0008545958 8.080795e-01 8.780412e-01 7 140794416 140794467 52 - 1.396 1.351 -0.156
ENSG00000157764 E036 1.0987354 0.0872116090 4.847452e-01 6.226972e-01 7 140799054 140800361 1308 - 0.271 0.391 0.749
ENSG00000157764 E037 29.1661489 0.0007045579 3.033313e-01 4.452389e-01 7 140800362 140800462 101 - 1.494 1.396 -0.338
ENSG00000157764 E038 15.3149525 0.0012592936 5.264899e-01 6.597212e-01 7 140800463 140800481 19 - 1.221 1.136 -0.303
ENSG00000157764 E039 0.0000000       7 140801020 140801411 392 -      
ENSG00000157764 E040 29.4539607 0.0007618291 7.087575e-01 8.063269e-01 7 140801412 140801560 149 - 1.482 1.429 -0.182
ENSG00000157764 E041 25.9715126 0.0008535771 1.203410e-01 2.204683e-01 7 140807960 140808062 103 - 1.463 1.322 -0.488
ENSG00000157764 E042 0.4460135 0.0274057593 3.324194e-01 4.760708e-01 7 140808063 140808236 174 - 0.218 0.000 -13.257
ENSG00000157764 E043 1.3318114 0.0096066587 2.455430e-02 6.096046e-02 7 140808237 140808316 80 - 0.471 0.000 -14.803
ENSG00000157764 E044 0.1472490 0.0428491989 1.000000e+00   7 140808317 140808338 22 - 0.085 0.000 -11.632
ENSG00000157764 E045 0.9965258 0.0142797951 8.347043e-01 8.965286e-01 7 140808883 140808891 9 - 0.272 0.296 0.168
ENSG00000157764 E046 31.6729157 0.0007212022 6.752718e-01 7.805975e-01 7 140808892 140808995 104 - 1.520 1.466 -0.186
ENSG00000157764 E047 1.0717687 0.0790260248 3.889228e-01 5.329995e-01 7 140822385 140822452 68 - 0.362 0.173 -1.418
ENSG00000157764 E048 0.1451727 0.0430457753 1.000000e+00   7 140823533 140824398 866 - 0.085 0.000 -11.631
ENSG00000157764 E049 0.0000000       7 140833969 140833971 3 -      
ENSG00000157764 E050 13.3802718 0.0012919182 2.733416e-09 3.742141e-08 7 140833972 140834608 637 - 0.888 1.404 1.856
ENSG00000157764 E051 35.4725898 0.0006487224 5.501741e-01 6.798301e-01 7 140834609 140834703 95 - 1.543 1.552 0.030
ENSG00000157764 E052 35.2905242 0.0006083045 8.206511e-01 8.868992e-01 7 140834704 140834872 169 - 1.556 1.514 -0.142
ENSG00000157764 E053 0.1482932 0.0409092879 2.005058e-01   7 140834873 140836233 1361 - 0.000 0.172 12.361
ENSG00000157764 E054 20.4896811 0.0011206861 4.594370e-01 5.995905e-01 7 140850111 140850212 102 - 1.344 1.257 -0.305
ENSG00000157764 E055 14.7412302 0.0012153916 7.573722e-01 8.422177e-01 7 140924566 140924929 364 - 1.192 1.136 -0.199