ENSG00000157734

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000560945 ENSG00000157734 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX22 protein_coding retained_intron 4.883766 8.7342 2.494557 0.3739065 0.06448152 -1.803771 0.2747441 0.3145834 0.1195908 0.09538429 0.06366876 -1.3246258 0.06217917 0.03660000 0.04836667 0.01176667 0.96473465 0.01275833 TRUE  
ENST00000561334 ENSG00000157734 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX22 protein_coding retained_intron 4.883766 8.7342 2.494557 0.3739065 0.06448152 -1.803771 0.2999389 0.2024332 0.2183435 0.04209022 0.04623020 0.1041965 0.07085417 0.02293333 0.08760000 0.06466667 0.01275833 0.01275833 FALSE  
MSTRG.11012.1 ENSG00000157734 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX22 protein_coding   4.883766 8.7342 2.494557 0.3739065 0.06448152 -1.803771 1.7954429 4.3458104 0.7118866 0.35452238 0.19637991 -2.5930971 0.32736667 0.49613333 0.28176667 -0.21436667 0.12007381 0.01275833    
MSTRG.11012.2 ENSG00000157734 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX22 protein_coding   4.883766 8.7342 2.494557 0.3739065 0.06448152 -1.803771 0.5185935 1.0435284 0.4456947 0.52706542 0.29277832 -1.2090898 0.11714167 0.12470000 0.18253333 0.05783333 0.98877635 0.01275833 TRUE  
MSTRG.11012.3 ENSG00000157734 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX22 protein_coding   4.883766 8.7342 2.494557 0.3739065 0.06448152 -1.803771 1.7177640 2.0935878 0.8527953 0.49545679 0.22839725 -1.2857619 0.36736250 0.23606667 0.34093333 0.10486667 0.62027992 0.01275833 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157734 E001 0.0000000       15 64151686 64151690 5 +      
ENSG00000157734 E002 0.6234634 0.0188526442 8.922820e-01 9.351783e-01 15 64151691 64151714 24 + 0.207 0.182 -0.223
ENSG00000157734 E003 3.2782838 0.0070698115 2.456071e-01 3.807716e-01 15 64151715 64151729 15 + 0.720 0.536 -0.807
ENSG00000157734 E004 3.4599882 0.0066953654 3.016069e-01 4.434258e-01 15 64151730 64151730 1 + 0.720 0.557 -0.707
ENSG00000157734 E005 9.1247869 0.0020578416 3.135099e-01 4.561224e-01 15 64151731 64151738 8 + 0.811 0.946 0.519
ENSG00000157734 E006 9.7472061 0.0021003899 5.478868e-01 6.778660e-01 15 64151739 64151740 2 + 0.886 0.963 0.292
ENSG00000157734 E007 11.1801910 0.0015928915 6.183004e-01 7.359909e-01 15 64151741 64151743 3 + 0.949 1.010 0.225
ENSG00000157734 E008 28.8451165 0.0009694673 8.505622e-01 9.072897e-01 15 64151744 64151850 107 + 1.393 1.380 -0.044
ENSG00000157734 E009 3.1594105 0.0134365008 1.261794e-01 2.288303e-01 15 64151851 64152242 392 + 0.720 0.466 -1.144
ENSG00000157734 E010 3.0549210 0.0082442844 6.400573e-01 7.533779e-01 15 64152243 64152326 84 + 0.451 0.537 0.423
ENSG00000157734 E011 6.3097380 0.0042714548 1.764534e-03 6.486476e-03 15 64152327 64152634 308 + 1.054 0.652 -1.565
ENSG00000157734 E012 7.3579436 0.0024430120 2.280488e-01 3.600954e-01 15 64152635 64152637 3 + 0.949 0.794 -0.595
ENSG00000157734 E013 44.5286612 0.0005510747 5.751946e-02 1.223655e-01 15 64152638 64152742 105 + 1.645 1.535 -0.374
ENSG00000157734 E014 5.1306076 0.0032458999 1.306305e-06 1.058266e-05 15 64152743 64153244 502 + 1.119 0.490 -2.539
ENSG00000157734 E015 40.0304595 0.0007003045 1.406005e-01 2.488495e-01 15 64153245 64153339 95 + 1.433 1.535 0.348
ENSG00000157734 E016 0.9868722 0.0194446599 7.466009e-01 8.343073e-01 15 64153340 64153386 47 + 0.206 0.272 0.518
ENSG00000157734 E017 0.9525055 0.0617635169 2.825714e-02 6.851710e-02 15 64153387 64153479 93 + 0.535 0.130 -2.799
ENSG00000157734 E018 3.8299025 0.0042113263 7.121457e-02 1.453563e-01 15 64153480 64153651 172 + 0.811 0.537 -1.165
ENSG00000157734 E019 30.7797467 0.0078491518 1.619727e-02 4.315847e-02 15 64153652 64153684 33 + 1.209 1.431 0.773
ENSG00000157734 E020 4.0534622 0.0059134889 4.347766e-01 5.770740e-01 15 64153685 64153934 250 + 0.721 0.598 -0.522
ENSG00000157734 E021 44.1143806 0.0005179475 1.303612e-02 3.599659e-02 15 64153935 64154002 68 + 1.414 1.581 0.575
ENSG00000157734 E022 6.9454285 0.0276303857 6.734842e-01 7.791627e-01 15 64154003 64154386 384 + 0.850 0.786 -0.249
ENSG00000157734 E023 95.8774862 0.0004537226 5.417049e-02 1.165497e-01 15 64154387 64154752 366 + 1.816 1.899 0.280
ENSG00000157734 E024 17.5700503 0.0077039978 9.426229e-01 9.679662e-01 15 64154753 64154903 151 + 1.175 1.170 -0.020
ENSG00000157734 E025 8.1769271 0.0021149228 8.503043e-01 9.071371e-01 15 64154904 64155106 203 + 0.886 0.862 -0.091
ENSG00000157734 E026 22.6829258 0.0009922849 1.440618e-02 3.914638e-02 15 64155107 64155390 284 + 1.424 1.231 -0.671
ENSG00000157734 E027 163.9759471 0.0061631838 6.911324e-01 7.926772e-01 15 64155391 64157481 2091 + 2.101 2.117 0.054