ENSG00000157637

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288439 ENSG00000157637 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A10 protein_coding protein_coding 54.11813 81.12633 31.8054 5.821361 0.976202 -1.350623 20.53153 26.23133 14.012176 3.6512814 0.9436581 -0.9041308 0.3956083 0.3205000 0.4397333 0.11923333 4.831191e-02 4.104333e-06 FALSE TRUE
ENST00000374759 ENSG00000157637 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A10 protein_coding protein_coding 54.11813 81.12633 31.8054 5.821361 0.976202 -1.350623 14.78590 25.58412 9.441255 1.7295818 0.5672576 -1.4372348 0.2659625 0.3168667 0.2970000 -0.01986667 8.184008e-01 4.104333e-06 FALSE TRUE
ENST00000573058 ENSG00000157637 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A10 protein_coding retained_intron 54.11813 81.12633 31.8054 5.821361 0.976202 -1.350623 12.73269 21.89149 5.332037 0.6960198 0.1346157 -2.0355671 0.2244333 0.2716000 0.1677000 -0.10390000 4.104333e-06 4.104333e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157637 E001 0.1451727 0.0428188740 1.677875e-01   17 81243354 81243881 528 - 0.190 0.000 -10.835
ENSG00000157637 E002 0.6224193 0.0181065051 3.167536e-01 4.595499e-01 17 81243882 81244810 929 - 0.321 0.142 -1.506
ENSG00000157637 E003 2.6130879 0.0060551622 2.272822e-01 3.591513e-01 17 81244811 81245003 193 - 0.322 0.545 1.195
ENSG00000157637 E004 785.6972360 0.0048035678 3.878996e-02 8.879456e-02 17 81245004 81246177 1174 - 2.759 2.833 0.246
ENSG00000157637 E005 175.2853723 0.0019825588 9.020439e-01 9.415900e-01 17 81246178 81246240 63 - 2.165 2.168 0.008
ENSG00000157637 E006 122.2300973 0.0002581950 9.099342e-01 9.467348e-01 17 81246241 81246271 31 - 2.015 2.006 -0.029
ENSG00000157637 E007 318.4375825 0.0001713175 1.273553e-02 3.529002e-02 17 81246272 81246614 343 - 2.377 2.433 0.186
ENSG00000157637 E008 120.2431620 0.0002617018 4.750928e-02 1.047507e-01 17 81246615 81246673 59 - 1.943 2.016 0.245
ENSG00000157637 E009 13.8002569 0.0016025619 1.869025e-01 3.098366e-01 17 81246674 81246884 211 - 1.199 1.065 -0.479
ENSG00000157637 E010 187.2157281 0.0002136801 2.173335e-01 3.471747e-01 17 81246885 81247058 174 - 2.165 2.199 0.113
ENSG00000157637 E011 72.3080211 0.0010769320 9.631914e-01 9.807462e-01 17 81247059 81247061 3 - 1.784 1.782 -0.004
ENSG00000157637 E012 36.5044136 0.0073154366 4.555466e-01 5.960737e-01 17 81247062 81247635 574 - 1.454 1.510 0.192
ENSG00000157637 E013 7.6180553 0.0131836246 2.968313e-01 4.381012e-01 17 81250070 81250093 24 - 0.731 0.882 0.593
ENSG00000157637 E014 282.8474886 0.0016136977 1.348319e-08 1.622324e-07 17 81250877 81251195 319 - 2.224 2.409 0.617
ENSG00000157637 E015 337.4043327 0.0005298239 2.067719e-08 2.404095e-07 17 81251196 81251492 297 - 2.331 2.474 0.476
ENSG00000157637 E016 348.7834376 0.0008386746 5.361741e-04 2.295101e-03 17 81251493 81251612 120 - 2.392 2.481 0.296
ENSG00000157637 E017 205.4191962 0.0012240173 4.352485e-09 5.732118e-08 17 81251613 81252194 582 - 2.069 2.275 0.687
ENSG00000157637 E018 251.0821288 0.0002288153 1.721324e-01 2.909681e-01 17 81252195 81252242 48 - 2.294 2.326 0.108
ENSG00000157637 E019 310.7738267 0.0013142037 6.203711e-03 1.915063e-02 17 81252243 81252315 73 - 2.353 2.430 0.259
ENSG00000157637 E020 898.2652112 0.0017229521 2.226978e-02 5.623383e-02 17 81252316 81252683 368 - 2.833 2.886 0.174
ENSG00000157637 E021 686.1105711 0.0017475337 8.039226e-01 8.752342e-01 17 81253073 81253240 168 - 2.752 2.758 0.020
ENSG00000157637 E022 568.1624652 0.0002197527 7.054965e-02 1.442524e-01 17 81260238 81260360 123 - 2.699 2.664 -0.119
ENSG00000157637 E023 338.3741425 0.0001859494 3.178807e-02 7.544196e-02 17 81260361 81260394 34 - 2.488 2.436 -0.174
ENSG00000157637 E024 442.4859883 0.0001697586 2.012915e-01 3.278050e-01 17 81270918 81271024 107 - 2.587 2.558 -0.097
ENSG00000157637 E025 361.6827853 0.0020952801 4.070634e-01 5.506780e-01 17 81272516 81272627 112 - 2.501 2.475 -0.088
ENSG00000157637 E026 444.7189070 0.0003513297 4.457333e-04 1.950406e-03 17 81275969 81276151 183 - 2.625 2.550 -0.250
ENSG00000157637 E027 345.6480092 0.0044746064 1.153035e-01 2.132911e-01 17 81277031 81277133 103 - 2.509 2.447 -0.209
ENSG00000157637 E028 19.0379520 0.0010185556 3.378440e-01 4.817293e-01 17 81279699 81280160 462 - 1.151 1.236 0.303
ENSG00000157637 E029 343.1351824 0.0009000622 5.406868e-03 1.703274e-02 17 81280609 81280733 125 - 2.512 2.438 -0.246
ENSG00000157637 E030 342.4684181 0.0006434374 1.931749e-02 5.002105e-02 17 81282189 81282332 144 - 2.502 2.441 -0.202
ENSG00000157637 E031 262.7723079 0.0020019947 2.043579e-03 7.361245e-03 17 81283409 81283502 94 - 2.418 2.317 -0.339
ENSG00000157637 E032 211.7449468 0.0002551689 8.794822e-06 5.920520e-05 17 81284850 81284895 46 - 2.341 2.214 -0.423
ENSG00000157637 E033 1.8079346 0.0096910562 9.375736e-01 9.647574e-01 17 81284896 81285714 819 - 0.422 0.405 -0.092
ENSG00000157637 E034 2.5422000 0.0059380381 2.826817e-01 4.227106e-01 17 81288733 81288945 213 - 0.322 0.521 1.081
ENSG00000157637 E035 262.1755669 0.0029283962 3.560684e-04 1.603654e-03 17 81289691 81289808 118 - 2.435 2.308 -0.426
ENSG00000157637 E036 340.5733062 0.0105360882 1.596418e-05 1.012725e-04 17 81294823 81295307 485 - 2.615 2.393 -0.739
ENSG00000157637 E037 0.1817044 0.0393992407 1.000000e+00   17 81295422 81295547 126 - 0.000 0.077 7.585