ENSG00000157613

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000530518 ENSG00000157613 HEK293_OSMI2_2hA HEK293_TMG_2hB CREB3L1 protein_coding protein_coding 0.8903899 1.578405 0.573916 0.07963952 0.02383581 -1.443746 0.1085276 0.2994867 0.000000 0.1461605 0.00000000 -4.9518055 0.09474583 0.1933333 0 -0.1933333 0.0437393329 0.0005512287 FALSE FALSE
ENST00000621158 ENSG00000157613 HEK293_OSMI2_2hA HEK293_TMG_2hB CREB3L1 protein_coding protein_coding 0.8903899 1.578405 0.573916 0.07963952 0.02383581 -1.443746 0.7402616 1.1371206 0.573916 0.1236279 0.02383581 -0.9741843 0.86827083 0.7196000 1 0.2804000 0.0005512287 0.0005512287 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157613 E001 9.2517687 0.002146932 0.008605453 0.0253019 11 46277662 46278213 552 + 1.135 0.859 -1.021
ENSG00000157613 E002 0.1817044 0.039303531 1.000000000   11 46295126 46295333 208 + 0.000 0.080 10.026
ENSG00000157613 E003 9.7683254 0.004669733 0.324929346 0.4683533 11 46299935 46300163 229 + 1.042 0.937 -0.388
ENSG00000157613 E004 5.8662134 0.012467304 0.378020653 0.5223170 11 46307816 46307939 124 + 0.671 0.808 0.558
ENSG00000157613 E005 3.1508287 0.044763722 0.949033346 0.9720457 11 46307940 46308000 61 + 0.560 0.580 0.089
ENSG00000157613 E006 4.6987842 0.004492820 0.582036140 0.7064601 11 46309989 46310067 79 + 0.759 0.683 -0.313
ENSG00000157613 E007 0.0000000       11 46310914 46311031 118 +      
ENSG00000157613 E008 5.9133200 0.003253633 0.133088946 0.2384282 11 46311032 46311156 125 + 0.923 0.734 -0.739
ENSG00000157613 E009 5.9541181 0.003038917 0.250681367 0.3867521 11 46311157 46311189 33 + 0.895 0.750 -0.568
ENSG00000157613 E010 11.6401099 0.001659338 0.642101378 0.7549678 11 46312325 46312474 150 + 0.998 1.051 0.194
ENSG00000157613 E011 6.5703688 0.065109441 0.645356059 0.7574641 11 46312612 46312623 12 + 0.760 0.850 0.358
ENSG00000157613 E012 7.6808066 0.036323106 0.666031682 0.7735788 11 46312624 46312670 47 + 0.923 0.868 -0.209
ENSG00000157613 E013 10.7878859 0.005440797 0.268288876 0.4067336 11 46312851 46312919 69 + 0.895 1.028 0.497
ENSG00000157613 E014 0.8480291 0.015048375 0.150080356 0.2617808 11 46315171 46315387 217 + 0.000 0.302 12.345
ENSG00000157613 E015 0.1817044 0.039303531 1.000000000   11 46315479 46315660 182 + 0.000 0.080 10.026
ENSG00000157613 E016 0.3697384 0.027274753 0.620750608 0.7378365 11 46315661 46316080 420 + 0.000 0.147 11.026
ENSG00000157613 E017 0.1482932 0.042028539 1.000000000   11 46316081 46316285 205 + 0.000 0.079 10.022
ENSG00000157613 E018 13.9680723 0.001762842 0.126941341 0.2298909 11 46316286 46316385 100 + 0.975 1.136 0.588
ENSG00000157613 E019 11.6525420 0.001701223 0.332045086 0.4756626 11 46317361 46317487 127 + 0.950 1.059 0.403
ENSG00000157613 E020 7.1228931 0.003525094 0.656067541 0.7658025 11 46320264 46320299 36 + 0.797 0.859 0.243
ENSG00000157613 E021 9.9545710 0.002070616 0.373205523 0.5176495 11 46320300 46320528 229 + 0.895 1.002 0.400
ENSG00000157613 E022 17.4416059 0.027749859 0.538518945 0.6699333 11 46320710 46321409 700 + 1.240 1.178 -0.217