ENSG00000157600

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372068 ENSG00000157600 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM164 protein_coding protein_coding 25.21665 33.89315 20.26775 2.300406 0.3718966 -0.7415218 8.282130 7.993036 9.032043 1.1646470 0.4830623 0.1761014 0.34456250 0.23406667 0.44523333 0.211166667 3.421237e-06 1.238157e-07 FALSE TRUE
ENST00000372072 ENSG00000157600 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM164 protein_coding protein_coding 25.21665 33.89315 20.26775 2.300406 0.3718966 -0.7415218 9.104420 18.014442 4.336763 0.7567104 0.3926175 -2.0519412 0.33255417 0.53603333 0.21400000 -0.322033333 1.238157e-07 1.238157e-07 FALSE FALSE
ENST00000372073 ENSG00000157600 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM164 protein_coding protein_coding 25.21665 33.89315 20.26775 2.300406 0.3718966 -0.7415218 2.774189 2.820602 1.755585 0.5458311 0.9763769 -0.6809622 0.11393333 0.08260000 0.08796667 0.005366667 8.965537e-01 1.238157e-07 FALSE TRUE
ENST00000497754 ENSG00000157600 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM164 protein_coding processed_transcript 25.21665 33.89315 20.26775 2.300406 0.3718966 -0.7415218 2.164103 1.814714 1.885166 0.9436611 0.2045896 0.0546536 0.09166667 0.05003333 0.09273333 0.042700000 7.106964e-01 1.238157e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157600 E001 2.9914398 0.0050716844 1.559385e-02 4.183313e-02 X 110002411 110002625 215 + 0.742 0.472 -1.201
ENSG00000157600 E002 0.5891098 0.0183234159 8.008177e-03 2.379841e-02 X 110002626 110002630 5 + 0.399 0.000 -34.020
ENSG00000157600 E003 0.9159869 0.0140125261 1.711022e-02 4.518434e-02 X 110002631 110002634 4 + 0.460 0.108 -2.744
ENSG00000157600 E004 0.9159869 0.0140125261 1.711022e-02 4.518434e-02 X 110002635 110002635 1 + 0.460 0.108 -2.744
ENSG00000157600 E005 7.6675737 0.0031533711 1.735929e-03 6.395817e-03 X 110002636 110002686 51 + 1.048 0.803 -0.927
ENSG00000157600 E006 25.0304728 0.0100159307 1.202820e-02 3.359735e-02 X 110002687 110002772 86 + 1.443 1.364 -0.274
ENSG00000157600 E007 0.4407149 0.0214421922 2.774931e-01 4.170619e-01 X 110003054 110003060 7 + 0.244 0.107 -1.424
ENSG00000157600 E008 0.6224193 0.0172671820 5.547432e-01 6.836902e-01 X 110003061 110003062 2 + 0.244 0.194 -0.423
ENSG00000157600 E009 7.3119276 0.0061070304 3.953360e-02 9.016459e-02 X 110003063 110003094 32 + 0.985 0.856 -0.486
ENSG00000157600 E010 14.6376681 0.0073055725 1.035701e-01 1.959381e-01 X 110003095 110003113 19 + 1.196 1.163 -0.117
ENSG00000157600 E011 15.1621441 0.0026161310 5.732241e-02 1.220230e-01 X 110003114 110003114 1 + 1.216 1.170 -0.163
ENSG00000157600 E012 33.6319235 0.0108713821 2.081477e-02 5.320150e-02 X 110003115 110003156 42 + 1.557 1.505 -0.176
ENSG00000157600 E013 25.9032409 0.0116560108 1.120179e-01 2.085073e-01 X 110003157 110003178 22 + 1.419 1.412 -0.024
ENSG00000157600 E014 68.4946597 0.0144034389 1.566031e-03 5.849482e-03 X 110003501 110003585 85 + 1.883 1.789 -0.315
ENSG00000157600 E015 108.5898185 0.0051400104 4.087318e-08 4.487829e-07 X 110003586 110003782 197 + 2.100 1.971 -0.431
ENSG00000157600 E016 75.0391276 0.0006782880 8.911362e-09 1.108782e-07 X 110003783 110003882 100 + 1.929 1.820 -0.370
ENSG00000157600 E017 44.3156413 0.0022262577 6.444226e-05 3.531545e-04 X 110003883 110003885 3 + 1.699 1.603 -0.324
ENSG00000157600 E018 161.7721907 0.0002087553 1.865909e-11 3.716652e-10 X 110003886 110004164 279 + 2.231 2.174 -0.191
ENSG00000157600 E019 0.2955422 0.0292333780 6.603947e-01   X 110065101 110065523 423 + 0.139 0.107 -0.425
ENSG00000157600 E020 101.5954673 0.0003875166 2.536072e-05 1.535478e-04 X 110067347 110067396 50 + 2.007 1.986 -0.068
ENSG00000157600 E021 116.9359333 0.0058293619 4.450184e-02 9.928747e-02 X 110109080 110109146 67 + 2.034 2.069 0.117
ENSG00000157600 E022 111.1501897 0.0005170811 5.494674e-03 1.727287e-02 X 110144798 110144854 57 + 2.012 2.045 0.113
ENSG00000157600 E023 84.5838460 0.0045924635 2.970729e-02 7.138364e-02 X 110144855 110144876 22 + 1.902 1.925 0.080
ENSG00000157600 E024 156.5453022 0.0009599649 1.371097e-04 6.907885e-04 X 110171420 110171520 101 + 2.173 2.185 0.038
ENSG00000157600 E025 235.8609358 0.0034281072 1.046683e-02 2.990093e-02 X 110173245 110173453 209 + 2.332 2.376 0.147
ENSG00000157600 E026 3057.2120433 0.0065731062 1.120005e-08 1.368207e-07 X 110173454 110177788 4335 + 3.326 3.544 0.723
ENSG00000157600 E027 15.0563151 0.0028041616 2.076949e-02 5.310081e-02 X 110182306 110182734 429 + 1.236 1.153 -0.292