ENSG00000157578

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358268 ENSG00000157578 HEK293_OSMI2_2hA HEK293_TMG_2hB LCA5L protein_coding protein_coding 0.6758904 0.2256492 1.110037 0.0350923 0.0806936 2.248833 0.01411910 0.00000000 0.07700284 0.000000000 0.07700284 3.121062 0.01494167 0.00000000 0.06080000 0.06080000 1.00000000 0.03203359 FALSE TRUE
ENST00000380671 ENSG00000157578 HEK293_OSMI2_2hA HEK293_TMG_2hB LCA5L protein_coding protein_coding 0.6758904 0.2256492 1.110037 0.0350923 0.0806936 2.248833 0.04161099 0.01847901 0.05538628 0.009568024 0.05538628 1.199089 0.06377083 0.08963333 0.05196667 -0.03766667 0.68015050 0.03203359 FALSE TRUE
ENST00000459939 ENSG00000157578 HEK293_OSMI2_2hA HEK293_TMG_2hB LCA5L protein_coding processed_transcript 0.6758904 0.2256492 1.110037 0.0350923 0.0806936 2.248833 0.04734479 0.00000000 0.11902786 0.000000000 0.05957139 3.689611 0.04268750 0.00000000 0.10696667 0.10696667 0.60837318 0.03203359 FALSE FALSE
ENST00000480612 ENSG00000157578 HEK293_OSMI2_2hA HEK293_TMG_2hB LCA5L protein_coding retained_intron 0.6758904 0.2256492 1.110037 0.0350923 0.0806936 2.248833 0.02822580 0.01882791 0.00000000 0.018827910 0.00000000 -1.527466 0.06998333 0.07480000 0.00000000 -0.07480000 0.33701684 0.03203359   FALSE
ENST00000485895 ENSG00000157578 HEK293_OSMI2_2hA HEK293_TMG_2hB LCA5L protein_coding protein_coding 0.6758904 0.2256492 1.110037 0.0350923 0.0806936 2.248833 0.20478345 0.17406312 0.36592532 0.020651078 0.05830742 1.030246 0.38747083 0.78246667 0.33656667 -0.44590000 0.03203359 0.03203359 FALSE TRUE
ENST00000490184 ENSG00000157578 HEK293_OSMI2_2hA HEK293_TMG_2hB LCA5L protein_coding processed_transcript 0.6758904 0.2256492 1.110037 0.0350923 0.0806936 2.248833 0.04298161 0.00000000 0.12920303 0.000000000 0.06914260 3.799119 0.03992917 0.00000000 0.10950000 0.10950000 0.62772660 0.03203359   FALSE
ENST00000491625 ENSG00000157578 HEK293_OSMI2_2hA HEK293_TMG_2hB LCA5L protein_coding retained_intron 0.6758904 0.2256492 1.110037 0.0350923 0.0806936 2.248833 0.15763388 0.01427916 0.22798329 0.014279161 0.03991438 3.293070 0.16912500 0.05306667 0.20393333 0.15086667 0.43858681 0.03203359 FALSE TRUE
ENST00000495240 ENSG00000157578 HEK293_OSMI2_2hA HEK293_TMG_2hB LCA5L protein_coding processed_transcript 0.6758904 0.2256492 1.110037 0.0350923 0.0806936 2.248833 0.02548454 0.00000000 0.06588582 0.000000000 0.06588582 2.923830 0.03414167 0.00000000 0.06603333 0.06603333 1.00000000 0.03203359 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157578 E001 0.0000000       21 39405728 39405843 116 -      
ENSG00000157578 E002 0.0000000       21 39405844 39405859 16 -      
ENSG00000157578 E003 0.4427912 0.098817575 0.5561997844 0.684912610 21 39405860 39405977 118 - 0.131 0.203 0.756
ENSG00000157578 E004 2.3709856 0.058191477 0.4695811608 0.608807253 21 39405978 39406612 635 - 0.541 0.341 -1.053
ENSG00000157578 E005 0.9557277 0.015275307 0.9231689973 0.955550804 21 39409979 39410096 118 - 0.275 0.204 -0.556
ENSG00000157578 E006 0.8042123 0.098303406 0.9832239280 0.993582100 21 39410264 39410367 104 - 0.232 0.205 -0.223
ENSG00000157578 E007 0.0000000       21 39411033 39411147 115 -      
ENSG00000157578 E008 0.8042123 0.098303406 0.9832239280 0.993582100 21 39411718 39411802 85 - 0.232 0.205 -0.223
ENSG00000157578 E009 0.8772652 0.024430887 0.2433488256 0.378099770 21 39420706 39420843 138 - 0.314 0.000 -13.623
ENSG00000157578 E010 7.2482429 0.003149446 0.0005086925 0.002192126 21 39421560 39422411 852 - 0.774 1.093 1.203
ENSG00000157578 E011 8.7622518 0.038693250 0.4460268216 0.587574097 21 39422412 39422975 564 - 0.934 0.947 0.049
ENSG00000157578 E012 3.1385776 0.008553424 0.9446369614 0.969249983 21 39422976 39422987 12 - 0.602 0.531 -0.325
ENSG00000157578 E013 4.0221975 0.004557949 0.7351447169 0.825960379 21 39422988 39423083 96 - 0.673 0.662 -0.045
ENSG00000157578 E014 5.4753590 0.006806204 0.6975392750 0.797645606 21 39423084 39423239 156 - 0.774 0.763 -0.045
ENSG00000157578 E015 2.0013715 0.020629570 0.7641889647 0.847321238 21 39423240 39423244 5 - 0.442 0.447 0.026
ENSG00000157578 E016 5.0606553 0.003665071 0.8329165762 0.895324734 21 39423245 39423419 175 - 0.761 0.663 -0.406
ENSG00000157578 E017 2.9078821 0.006234174 0.6677347828 0.774887298 21 39423420 39423490 71 - 0.583 0.447 -0.650
ENSG00000157578 E018 0.7406253 0.017267182 0.3246963964 0.468112249 21 39427759 39427905 147 - 0.275 0.000 -13.420
ENSG00000157578 E019 0.8900644 0.167929092 0.2880180557 0.428559194 21 39428172 39428207 36 - 0.314 0.000 -13.613
ENSG00000157578 E020 0.7385489 0.106486536 0.3550506854 0.499393327 21 39428208 39428209 2 - 0.275 0.000 -13.416
ENSG00000157578 E021 0.5870335 0.128197992 0.5004684747 0.636725045 21 39428210 39428214 5 - 0.232 0.000 -13.170
ENSG00000157578 E022 0.4418608 0.031787186 0.6811581833 0.784923934 21 39428215 39428221 7 - 0.185 0.000 -12.850
ENSG00000157578 E023 1.0383575 0.101912075 0.7509381842 0.837508698 21 39428222 39428284 63 - 0.314 0.203 -0.830
ENSG00000157578 E024 0.8931848 0.103315519 0.9125275397 0.948562670 21 39428285 39428304 20 - 0.275 0.203 -0.568
ENSG00000157578 E025 1.0769655 0.015520014 0.5722579552 0.698394588 21 39428305 39428401 97 - 0.275 0.342 0.441
ENSG00000157578 E026 0.7728905 0.016030230 1.0000000000 1.000000000 21 39428402 39428461 60 - 0.232 0.204 -0.235
ENSG00000157578 E027 0.4439371 0.022373576 0.6789264384 0.783269695 21 39428462 39428503 42 - 0.185 0.000 -12.849
ENSG00000157578 E028 0.0000000       21 39428504 39428522 19 -      
ENSG00000157578 E029 1.7703363 0.009218955 0.2835680577 0.423708220 21 39429131 39429187 57 - 0.469 0.204 -1.696
ENSG00000157578 E030 1.6177767 0.014627766 0.0602926445 0.127108907 21 39429188 39429211 24 - 0.469 0.000 -14.331
ENSG00000157578 E031 0.0000000       21 39429212 39429394 183 -      
ENSG00000157578 E032 0.7384352 0.016648859 0.3260172855 0.469461368 21 39435420 39435542 123 - 0.275 0.000 -13.420
ENSG00000157578 E033 0.1451727 0.047428625 1.0000000000   21 39435543 39435573 31 - 0.071 0.000 -11.564
ENSG00000157578 E034 0.0000000       21 39436097 39436167 71 -      
ENSG00000157578 E035 0.0000000       21 39438684 39438718 35 -      
ENSG00000157578 E036 0.0000000       21 39438719 39438936 218 -      
ENSG00000157578 E037 0.0000000       21 39439634 39439773 140 -      
ENSG00000157578 E038 0.3332198 0.032117087 0.2949095019   21 39443459 39444134 676 - 0.071 0.204 1.764
ENSG00000157578 E039 0.7405115 0.260369635 0.4476874812 0.589057238 21 39444135 39444201 67 - 0.275 0.000 -13.409
ENSG00000157578 E040 0.8856842 0.031862812 0.2450104563 0.380039431 21 39444644 39444745 102 - 0.314 0.000 -13.623
ENSG00000157578 E041 0.4427912 0.098817575 0.5561997844 0.684912610 21 39445450 39445724 275 - 0.131 0.203 0.756
ENSG00000157578 E042 0.6674587 0.021166629 0.7794334646 0.858166817 21 39445725 39445805 81 - 0.185 0.204 0.181