ENSG00000157570

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340160 ENSG00000157570 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN18 protein_coding protein_coding 4.55735 6.739309 5.027232 0.3534048 0.09195102 -0.4221086 3.4105799 5.3872313 3.4419734 0.07292685 0.21939564 -0.6447982 0.75919167 0.8032333 0.6855 -0.1177333 0.314904055 0.001832853 FALSE TRUE
ENST00000520358 ENSG00000157570 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN18 protein_coding protein_coding 4.55735 6.739309 5.027232 0.3534048 0.09195102 -0.4221086 0.6573034 0.3780695 1.0682185 0.37806952 0.21461594 1.4742625 0.14166667 0.0515000 0.2124 0.1609000 0.138653947 0.001832853 FALSE TRUE
MSTRG.5433.5 ENSG00000157570 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN18 protein_coding   4.55735 6.739309 5.027232 0.3534048 0.09195102 -0.4221086 0.2628818 0.9276229 0.0950382 0.11799239 0.05178218 -3.1580937 0.05286667 0.1386000 0.0192 -0.1194000 0.001832853 0.001832853 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157570 E001 0.0000000       11 44726465 44726513 49 +      
ENSG00000157570 E002 0.0000000       11 44726811 44726881 71 +      
ENSG00000157570 E003 1.0373134 0.0122874714 0.0008423130 0.0034099853 11 44726962 44727102 141 + 0.558 0.000 -12.685
ENSG00000157570 E004 2.0565526 0.1290498285 0.0806179568 0.1605199385 11 44727103 44727158 56 + 0.639 0.331 -1.559
ENSG00000157570 E005 3.4110749 0.0718482082 0.1919995904 0.3162661170 11 44727159 44727173 15 + 0.739 0.552 -0.803
ENSG00000157570 E006 10.5005978 0.0254569107 0.2082487056 0.3363837259 11 44727174 44727287 114 + 1.112 0.995 -0.427
ENSG00000157570 E007 18.7561075 0.0040847480 0.2630988699 0.4009564045 11 44764426 44764512 87 + 1.310 1.257 -0.187
ENSG00000157570 E008 0.0000000       11 44859603 44859740 138 +      
ENSG00000157570 E009 31.2589647 0.0147325442 0.5394898923 0.6707492198 11 44860328 44860469 142 + 1.495 1.492 -0.008
ENSG00000157570 E010 5.9478851 0.0029713522 0.0128341745 0.0355259475 11 44897752 44897828 77 + 0.558 0.938 1.551
ENSG00000157570 E011 21.9674132 0.0196737445 0.9873797232 0.9961769277 11 44906407 44906479 73 + 1.318 1.363 0.158
ENSG00000157570 E012 0.2924217 0.0290785164 0.1191230038   11 44909523 44909704 182 + 0.242 0.000 -12.729
ENSG00000157570 E013 38.5402208 0.0006431859 0.0032731113 0.0110710977 11 44909705 44909899 195 + 1.654 1.530 -0.421
ENSG00000157570 E014 0.1482932 0.0420934838 0.6747918660   11 44917582 44917971 390 + 0.000 0.108 10.206
ENSG00000157570 E015 37.6639493 0.0053183473 0.0099433182 0.0286194440 11 44917972 44918046 75 + 1.643 1.518 -0.427
ENSG00000157570 E016 42.3617765 0.0090274970 0.0364174055 0.0843759491 11 44919214 44919312 99 + 1.678 1.579 -0.337
ENSG00000157570 E017 0.0000000       11 44919313 44919321 9 +      
ENSG00000157570 E018 0.1472490 0.0429505569 0.3458825070   11 44919666 44919673 8 + 0.138 0.000 -11.614
ENSG00000157570 E019 0.1472490 0.0429505569 0.3458825070   11 44919674 44919816 143 + 0.138 0.000 -11.614
ENSG00000157570 E020 47.7530351 0.0123346483 0.1513920402 0.2635615498 11 44919817 44919999 183 + 1.705 1.650 -0.184
ENSG00000157570 E021 0.4847352 0.2334980250 0.4373122678 0.5792846940 11 44925717 44925799 83 + 0.243 0.109 -1.398
ENSG00000157570 E022 0.5202097 0.0205863381 0.3759567873 0.5203381464 11 44926367 44926673 307 + 0.242 0.109 -1.395
ENSG00000157570 E023 33.9715532 0.0008237886 0.0288457093 0.0696961162 11 44926674 44926757 84 + 1.580 1.488 -0.312
ENSG00000157570 E024 295.3467094 0.0009880764 0.3604279284 0.5047344438 11 44929131 44930861 1731 + 2.445 2.468 0.076
ENSG00000157570 E025 275.2781915 0.0119414074 0.0001823394 0.0008879202 11 44930862 44932423 1562 + 2.296 2.497 0.668