ENSG00000157557

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360938 ENSG00000157557 HEK293_OSMI2_2hA HEK293_TMG_2hB ETS2 protein_coding protein_coding 10.80877 10.61954 11.83782 0.2802169 0.1339124 0.156543 7.178411 5.584253 9.4771828 0.6345947 0.1288685 0.7620342 0.6631667 0.5249667 0.80066667 0.27570000 6.436016e-05 4.200801e-24 FALSE TRUE
ENST00000456966 ENSG00000157557 HEK293_OSMI2_2hA HEK293_TMG_2hB ETS2 protein_coding protein_coding 10.80877 10.61954 11.83782 0.2802169 0.1339124 0.156543 0.520519 0.000000 0.9344908 0.0000000 0.1135010 6.5614648 0.0464125 0.0000000 0.07873333 0.07873333 2.136966e-13 4.200801e-24 FALSE FALSE
ENST00000662305 ENSG00000157557 HEK293_OSMI2_2hA HEK293_TMG_2hB ETS2 protein_coding protein_coding 10.80877 10.61954 11.83782 0.2802169 0.1339124 0.156543 2.140900 4.554925 0.0000000 0.6508082 0.0000000 -8.8344474 0.2003792 0.4287333 0.00000000 -0.42873333 4.200801e-24 4.200801e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157557 E001 0.5159433 0.2094571758 6.354840e-01 7.497792e-01 21 38805183 38805257 75 + 0.213 0.127 -0.900
ENSG00000157557 E002 1.0663419 0.4153337554 8.549632e-01 9.102927e-01 21 38805258 38805440 183 + 0.290 0.312 0.148
ENSG00000157557 E003 0.5901394 0.3893201379 6.476535e-01 7.592810e-01 21 38805441 38805616 176 + 0.119 0.231 1.145
ENSG00000157557 E004 6.7539183 0.0486230983 4.406360e-01 5.823190e-01 21 38805895 38805928 34 + 0.935 0.829 -0.405
ENSG00000157557 E005 12.6554088 0.0043926398 1.391671e-05 8.944187e-05 21 38805929 38805950 22 + 1.301 0.886 -1.505
ENSG00000157557 E006 17.9819770 0.0053629316 4.009621e-05 2.310392e-04 21 38805951 38805970 20 + 1.421 1.081 -1.196
ENSG00000157557 E007 17.7732067 0.0011008594 1.824105e-07 1.761501e-06 21 38805971 38805982 12 + 1.441 1.029 -1.456
ENSG00000157557 E008 38.8808531 0.0005780108 2.197096e-07 2.089525e-06 21 38805983 38806120 138 + 1.721 1.454 -0.913
ENSG00000157557 E009 3.0773790 0.0143927084 4.404403e-02 9.846601e-02 21 38806451 38806690 240 + 0.735 0.427 -1.405
ENSG00000157557 E010 2.4442514 0.0060546150 1.676211e-03 6.206939e-03 21 38806691 38806808 118 + 0.735 0.222 -2.730
ENSG00000157557 E011 1.9658720 0.0086219130 1.100447e-03 4.304606e-03 21 38808094 38808263 170 + 0.681 0.125 -3.507
ENSG00000157557 E012 0.6299079 0.0195449143 3.138314e-01 4.564609e-01 21 38809403 38809449 47 + 0.290 0.125 -1.507
ENSG00000157557 E013 1.5606566 0.0251620251 5.889865e-02 1.247490e-01 21 38809636 38809796 161 + 0.549 0.222 -1.922
ENSG00000157557 E014 49.4163672 0.0004496736 2.988007e-03 1.022856e-02 21 38810035 38810106 72 + 1.764 1.641 -0.414
ENSG00000157557 E015 81.4745954 0.0004081276 1.100073e-02 3.116392e-02 21 38813003 38813114 112 + 1.953 1.878 -0.250
ENSG00000157557 E016 98.5413368 0.0020588586 1.698745e-01 2.880495e-01 21 38814273 38814392 120 + 2.013 1.981 -0.108
ENSG00000157557 E017 132.7626821 0.0002902472 1.867701e-02 4.862377e-02 21 38814781 38814981 201 + 2.151 2.105 -0.155
ENSG00000157557 E018 89.8504115 0.0002908375 4.282688e-02 9.622752e-02 21 38817008 38817091 84 + 1.984 1.934 -0.167
ENSG00000157557 E019 155.6109912 0.0002834587 4.193740e-03 1.368830e-02 21 38818425 38818646 222 + 2.223 2.169 -0.184
ENSG00000157557 E020 188.8622181 0.0002246596 4.087239e-01 5.523443e-01 21 38819503 38819766 264 + 2.256 2.301 0.149
ENSG00000157557 E021 0.3729606 0.0283187246 1.000000e+00 1.000000e+00 21 38819767 38819871 105 + 0.120 0.125 0.080
ENSG00000157557 E022 117.8485988 0.0002469257 3.706945e-02 8.560192e-02 21 38821586 38821704 119 + 2.025 2.115 0.303
ENSG00000157557 E023 608.7118287 0.0014715432 4.271908e-14 1.280226e-12 21 38822674 38824955 2282 + 2.699 2.849 0.498