ENSG00000157540

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398960 ENSG00000157540 HEK293_OSMI2_2hA HEK293_TMG_2hB DYRK1A protein_coding protein_coding 7.244024 2.123533 11.21917 0.2399352 0.4285089 2.395936 0.4025999 1.1332257 0.00000000 0.13920857 0.00000000 -6.836966 0.12767083 0.5607667 0.000000000 -0.560766667 6.599293e-12 6.599293e-12 FALSE TRUE
ENST00000643624 ENSG00000157540 HEK293_OSMI2_2hA HEK293_TMG_2hB DYRK1A protein_coding protein_coding 7.244024 2.123533 11.21917 0.2399352 0.4285089 2.395936 0.3491844 0.0000000 0.05713299 0.00000000 0.05713299 2.747022 0.08036250 0.0000000 0.004733333 0.004733333 1.000000e+00 6.599293e-12 FALSE TRUE
ENST00000643854 ENSG00000157540 HEK293_OSMI2_2hA HEK293_TMG_2hB DYRK1A protein_coding protein_coding 7.244024 2.123533 11.21917 0.2399352 0.4285089 2.395936 2.4580078 0.2934016 5.18454281 0.29340164 0.46694571 4.097696 0.27032083 0.1133667 0.465700000 0.352333333 1.134298e-01 6.599293e-12 FALSE TRUE
ENST00000644367 ENSG00000157540 HEK293_OSMI2_2hA HEK293_TMG_2hB DYRK1A protein_coding processed_transcript 7.244024 2.123533 11.21917 0.2399352 0.4285089 2.395936 1.0443097 0.0000000 0.99830794 0.00000000 0.54554338 6.655792 0.10411250 0.0000000 0.086733333 0.086733333 4.309271e-01 6.599293e-12 FALSE TRUE
ENST00000645424 ENSG00000157540 HEK293_OSMI2_2hA HEK293_TMG_2hB DYRK1A protein_coding protein_coding 7.244024 2.123533 11.21917 0.2399352 0.4285089 2.395936 0.9195207 0.0000000 1.31492646 0.00000000 0.17820251 7.049768 0.09008333 0.0000000 0.116366667 0.116366667 7.937313e-07 6.599293e-12 FALSE TRUE
ENST00000647188 ENSG00000157540 HEK293_OSMI2_2hA HEK293_TMG_2hB DYRK1A protein_coding protein_coding 7.244024 2.123533 11.21917 0.2399352 0.4285089 2.395936 1.2510640 0.3832876 2.38157709 0.06354496 0.09797243 2.604306 0.19681250 0.1805333 0.212966667 0.032433333 7.655526e-01 6.599293e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157540 E001 0.0000000       21 37365573 37365789 217 +      
ENSG00000157540 E002 0.0000000       21 37365790 37365834 45 +      
ENSG00000157540 E003 0.3289534 0.0314567382 5.419980e-01   21 37365835 37366185 351 + 0.072 0.202 1.724
ENSG00000157540 E004 5.0961428 0.0048976036 1.183154e-01 2.175236e-01 21 37366773 37366933 161 + 0.766 0.658 -0.446
ENSG00000157540 E005 9.6591500 0.0635919473 1.144386e-01 2.120173e-01 21 37366934 37367100 167 + 1.013 0.876 -0.514
ENSG00000157540 E006 14.5842757 0.0256058242 4.657391e-04 2.029042e-03 21 37367101 37367382 282 + 1.210 0.876 -1.223
ENSG00000157540 E007 13.9057700 0.0071025974 8.702856e-06 5.862985e-05 21 37367383 37367556 174 + 1.201 0.801 -1.482
ENSG00000157540 E008 7.9345626 0.0036093628 1.579913e-03 5.893548e-03 21 37367557 37367580 24 + 0.966 0.658 -1.215
ENSG00000157540 E009 12.3883013 0.0014048859 4.382989e-05 2.503827e-04 21 37367581 37367628 48 + 1.143 0.801 -1.276
ENSG00000157540 E010 0.0000000       21 37368016 37368058 43 +      
ENSG00000157540 E011 0.0000000       21 37368059 37368132 74 +      
ENSG00000157540 E012 0.1472490 0.0438468456 1.000000e+00   21 37375094 37375117 24 + 0.072 0.000 -10.460
ENSG00000157540 E013 0.4418608 0.0266089447 3.108591e-01 4.532961e-01 21 37410570 37410609 40 + 0.187 0.000 -12.137
ENSG00000157540 E014 0.4418608 0.0266089447 3.108591e-01 4.532961e-01 21 37410610 37410670 61 + 0.187 0.000 -12.137
ENSG00000157540 E015 0.1472490 0.0438468456 1.000000e+00   21 37415490 37415565 76 + 0.072 0.000 -10.460
ENSG00000157540 E016 0.1472490 0.0438468456 1.000000e+00   21 37418905 37420298 1394 + 0.072 0.000 -10.460
ENSG00000157540 E017 9.1000837 0.0018344345 1.751631e-04 8.576038e-04 21 37420299 37420311 13 + 1.028 0.658 -1.447
ENSG00000157540 E018 11.3467216 0.0015416341 2.493121e-04 1.172287e-03 21 37420312 37420327 16 + 1.102 0.801 -1.129
ENSG00000157540 E019 14.5146569 0.0012615778 5.693100e-04 2.418904e-03 21 37420328 37420374 47 + 1.185 0.968 -0.791
ENSG00000157540 E020 8.8951058 0.0019393114 6.151742e-02 1.291864e-01 21 37420375 37420384 10 + 0.966 0.875 -0.340
ENSG00000157540 E021 1.6994589 0.0867124374 9.831166e-01 9.934896e-01 21 37421774 37421866 93 + 0.353 0.448 0.526
ENSG00000157540 E022 0.4439371 0.0215583846 3.090424e-01 4.513336e-01 21 37425690 37425781 92 + 0.187 0.000 -12.188
ENSG00000157540 E023 0.2966881 0.0270542012 5.423700e-01   21 37428867 37428908 42 + 0.133 0.000 -11.573
ENSG00000157540 E024 1.2651013 0.0150275104 2.425515e-01 3.771486e-01 21 37430269 37430400 132 + 0.353 0.202 -1.083
ENSG00000157540 E025 1.6533754 0.0116618143 9.853653e-01 9.948863e-01 21 37456130 37456308 179 + 0.353 0.444 0.504
ENSG00000157540 E026 30.1311072 0.0008828922 4.572780e-05 2.601265e-04 21 37472684 37472779 96 + 1.475 1.325 -0.520
ENSG00000157540 E027 38.2033429 0.0008192388 1.437426e-06 1.154077e-05 21 37472780 37472880 101 + 1.581 1.412 -0.578
ENSG00000157540 E028 4.2553952 0.0038851274 7.437581e-01 8.323092e-01 21 37478181 37478207 27 + 0.626 0.801 0.723
ENSG00000157540 E029 35.2148227 0.0006503426 6.019507e-07 5.242633e-06 21 37478208 37478284 77 + 1.553 1.359 -0.667
ENSG00000157540 E030 23.3355451 0.0008032707 1.678523e-04 8.259297e-04 21 37478285 37478300 16 + 1.376 1.214 -0.565
ENSG00000157540 E031 53.5836732 0.0004726461 3.851694e-06 2.812673e-05 21 37480638 37480826 189 + 1.712 1.615 -0.329
ENSG00000157540 E032 0.0000000       21 37480827 37481649 823 +      
ENSG00000157540 E033 0.0000000       21 37486148 37486466 319 +      
ENSG00000157540 E034 57.0428342 0.0004305719 4.364455e-07 3.905313e-06 21 37486467 37486614 148 + 1.741 1.627 -0.386
ENSG00000157540 E035 0.4439371 0.0215583846 3.090424e-01 4.513336e-01 21 37486615 37486639 25 + 0.187 0.000 -12.188
ENSG00000157540 E036 0.5954526 0.0183254329 1.874529e-01 3.105315e-01 21 37486640 37486667 28 + 0.235 0.000 -12.614
ENSG00000157540 E037 3.8074097 0.0045723694 1.019835e-01 1.935297e-01 21 37486668 37488127 1460 + 0.678 0.527 -0.669
ENSG00000157540 E038 0.8083650 0.1439150384 6.608371e-01 7.694373e-01 21 37488785 37488863 79 + 0.234 0.203 -0.260
ENSG00000157540 E039 87.8072143 0.0003692338 3.948726e-10 6.304883e-09 21 37490175 37490461 287 + 1.925 1.812 -0.380
ENSG00000157540 E040 57.8564686 0.0004538810 1.302530e-04 6.599458e-04 21 37493017 37493163 147 + 1.731 1.689 -0.142
ENSG00000157540 E041 0.0000000       21 37496091 37496117 27 +      
ENSG00000157540 E042 54.4835648 0.0004540954 4.290335e-04 1.886220e-03 21 37496118 37496258 141 + 1.700 1.668 -0.108
ENSG00000157540 E043 0.7425998 0.0637118187 6.777666e-01 7.823976e-01 21 37501326 37505282 3957 + 0.187 0.337 1.127
ENSG00000157540 E044 71.0908554 0.0006686795 4.021057e-06 2.923166e-05 21 37505283 37505589 307 + 1.818 1.753 -0.221
ENSG00000157540 E045 42.3055495 0.0005441457 9.121435e-06 6.119081e-05 21 37506099 37506223 125 + 1.614 1.494 -0.412
ENSG00000157540 E046 0.1515154 0.0430540531 1.000000e+00   21 37506224 37506270 47 + 0.072 0.000 -10.466
ENSG00000157540 E047 0.1515154 0.0430540531 1.000000e+00   21 37506271 37506354 84 + 0.072 0.000 -10.466
ENSG00000157540 E048 850.0210406 0.0039364329 2.036363e-36 5.472097e-34 21 37511911 37526358 14448 + 2.754 3.101 1.155