ENSG00000157538

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309117 ENSG00000157538 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS26C protein_coding protein_coding 17.30782 14.19309 20.89808 1.496604 0.1582052 0.5578562 13.91957 12.1705 16.28256 1.330413 0.3237551 0.4196397 0.8076708 0.8569667 0.7792333 -0.07773333 0.02794436 0.02794436 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157538 E001 3.3587846 0.0775783210 2.526578e-01 3.890472e-01 21 37220117 37220157 41 - 0.520 0.754 1.014
ENSG00000157538 E002 5.2107290 0.0048441148 2.920651e-01 4.330030e-01 21 37220158 37220323 166 - 0.728 0.879 0.597
ENSG00000157538 E003 1.4393170 0.0092331742 4.845098e-01 6.224920e-01 21 37223420 37223421 2 - 0.437 0.322 -0.663
ENSG00000157538 E004 485.8448326 0.0022082255 1.153015e-05 7.552561e-05 21 37223422 37224404 983 - 2.630 2.747 0.392
ENSG00000157538 E005 393.2097888 0.0008541845 7.985498e-02 1.593387e-01 21 37224405 37225298 894 - 2.576 2.625 0.161
ENSG00000157538 E006 165.2898791 0.0002627133 1.635159e-01 2.797201e-01 21 37225299 37225471 173 - 2.236 2.211 -0.083
ENSG00000157538 E007 100.7460966 0.0003381100 2.587328e-01 3.960410e-01 21 37225472 37225515 44 - 2.023 1.997 -0.088
ENSG00000157538 E008 101.1320991 0.0009043498 9.538850e-01 9.751224e-01 21 37225516 37225543 28 - 2.005 2.014 0.031
ENSG00000157538 E009 120.0506453 0.0035580850 6.380763e-01 7.518076e-01 21 37225544 37225626 83 - 2.090 2.076 -0.046
ENSG00000157538 E010 13.1431762 0.0092719340 1.139265e-02 3.210138e-02 21 37225627 37227653 2027 - 1.257 1.006 -0.903
ENSG00000157538 E011 159.2862700 0.0002185242 5.276429e-01 6.606634e-01 21 37227654 37227806 153 - 2.211 2.207 -0.013
ENSG00000157538 E012 70.9334082 0.0005085368 3.718833e-01 5.163640e-01 21 37228223 37228241 19 - 1.876 1.852 -0.080
ENSG00000157538 E013 161.5122069 0.0002746124 5.540576e-03 1.739235e-02 21 37228242 37228373 132 - 2.246 2.183 -0.212
ENSG00000157538 E014 2.3844462 0.0436344773 6.853457e-01 7.881214e-01 21 37228374 37229144 771 - 0.481 0.554 0.349
ENSG00000157538 E015 0.5169874 0.0203051583 4.554751e-01 5.959966e-01 21 37229145 37229222 78 - 0.110 0.238 1.337
ENSG00000157538 E016 1.1081736 0.0124666130 3.798696e-01 5.241301e-01 21 37229223 37229483 261 - 0.389 0.238 -0.985
ENSG00000157538 E017 1.5801467 0.0153229149 1.215001e-01 2.220748e-01 21 37230518 37230818 301 - 0.272 0.551 1.555
ENSG00000157538 E018 2.4293097 0.0064516380 2.511273e-01 3.872887e-01 21 37231493 37231590 98 - 0.437 0.632 0.921
ENSG00000157538 E019 2.3366520 0.0103253256 7.091844e-01 8.066334e-01 21 37231591 37231975 385 - 0.481 0.552 0.337
ENSG00000157538 E020 146.0155849 0.0002451681 1.101354e-03 4.307532e-03 21 37232377 37232451 75 - 2.209 2.127 -0.273
ENSG00000157538 E021 3.5020975 0.0044195143 7.057562e-01 8.040762e-01 21 37232452 37232645 194 - 0.678 0.633 -0.194
ENSG00000157538 E022 0.9694574 0.0638494314 5.930811e-01 7.155431e-01 21 37233292 37233361 70 - 0.334 0.239 -0.663
ENSG00000157538 E023 130.3469089 0.0003080628 2.532028e-01 3.896996e-01 21 37233362 37233442 81 - 2.133 2.111 -0.073
ENSG00000157538 E024 1.5023550 0.3906450422 2.877042e-02 6.954348e-02 21 37238205 37238355 151 - 0.593 0.000 -13.404
ENSG00000157538 E025 1.1972479 0.0747686973 7.344754e-03 2.211446e-02 21 37238356 37238459 104 - 0.521 0.000 -13.978
ENSG00000157538 E026 174.9527621 0.0002459398 1.979797e-01 3.236960e-01 21 37238460 37238609 150 - 2.261 2.241 -0.068
ENSG00000157538 E027 142.9051603 0.0051282980 9.475071e-01 9.709841e-01 21 37240496 37240639 144 - 2.156 2.166 0.034
ENSG00000157538 E028 19.9064990 0.0020113351 2.139865e-03 7.658423e-03 21 37261082 37261937 856 - 1.423 1.193 -0.803
ENSG00000157538 E029 0.0000000       21 37266792 37266847 56 -      
ENSG00000157538 E030 0.1472490 0.0438016460 6.020531e-01   21 37266848 37267153 306 - 0.110 0.000 -11.275
ENSG00000157538 E031 159.0484486 0.0120405665 7.939637e-01 8.683361e-01 21 37267238 37267919 682 - 2.213 2.195 -0.058