ENSG00000157514

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372382 ENSG00000157514 HEK293_OSMI2_2hA HEK293_TMG_2hB TSC22D3 protein_coding protein_coding 68.88696 130.8009 37.62646 10.83797 0.9252366 -1.79728 2.890096 4.185111 3.545210 0.6843729 0.3280070 -0.2387741 0.05069583 0.03193333 0.09390000 0.06196667 7.683277e-07 6.676707e-11 FALSE TRUE
ENST00000372383 ENSG00000157514 HEK293_OSMI2_2hA HEK293_TMG_2hB TSC22D3 protein_coding protein_coding 68.88696 130.8009 37.62646 10.83797 0.9252366 -1.79728 3.921102 5.932687 3.376884 0.2491953 0.2280369 -0.8111570 0.06271250 0.04570000 0.09013333 0.04443333 1.253288e-04 6.676707e-11 FALSE TRUE
ENST00000372397 ENSG00000157514 HEK293_OSMI2_2hA HEK293_TMG_2hB TSC22D3 protein_coding protein_coding 68.88696 130.8009 37.62646 10.83797 0.9252366 -1.79728 50.937636 100.028952 22.646144 7.4551492 0.6941080 -2.1425876 0.71649167 0.76590000 0.60190000 -0.16400000 6.676707e-11 6.676707e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157514 E001 7.2395223 0.1399747761 5.887243e-02 1.247004e-01 X 107713221 107713223 3 - 0.349 0.898 2.483
ENSG00000157514 E002 2172.4208808 0.0034074827 5.018605e-06 3.571599e-05 X 107713224 107713999 776 - 3.107 3.254 0.490
ENSG00000157514 E003 1490.2338811 0.0010795893 8.783962e-02 1.718432e-01 X 107714000 107714369 370 - 3.013 3.080 0.223
ENSG00000157514 E004 794.9603575 0.0001000319 9.155301e-01 9.505394e-01 X 107714370 107714486 117 - 2.764 2.806 0.139
ENSG00000157514 E005 909.3030977 0.0001442359 5.768909e-01 7.022441e-01 X 107714487 107714676 190 - 2.816 2.864 0.160
ENSG00000157514 E006 504.7495820 0.0002650993 1.394889e-01 2.473214e-01 X 107714677 107714749 73 - 2.592 2.602 0.031
ENSG00000157514 E007 6.4430895 0.0026596604 5.525949e-01 6.818652e-01 X 107715773 107715897 125 - 0.816 0.764 -0.205
ENSG00000157514 E008 2.2778815 0.0480865303 1.724244e-01 2.913630e-01 X 107715898 107715898 1 - 0.611 0.378 -1.152
ENSG00000157514 E009 263.8313797 0.0032440225 3.096636e-01 4.520016e-01 X 107715899 107715902 4 - 2.320 2.316 -0.013
ENSG00000157514 E010 300.2892749 0.0022786151 1.647181e-01 2.813194e-01 X 107715903 107715911 9 - 2.382 2.371 -0.036
ENSG00000157514 E011 295.0676693 0.0025455852 1.047163e-01 1.976901e-01 X 107715912 107715922 11 - 2.382 2.361 -0.069
ENSG00000157514 E012 354.7242396 0.0023368385 2.425053e-02 6.033000e-02 X 107715923 107715950 28 - 2.474 2.438 -0.121
ENSG00000157514 E013 21.7970740 0.0011787622 8.290569e-02 1.640955e-01 X 107715951 107716314 364 - 1.342 1.230 -0.391
ENSG00000157514 E014 12.6407012 0.0013812197 1.117262e-01 2.080952e-01 X 107716315 107716545 231 - 1.144 1.012 -0.481
ENSG00000157514 E015 569.0343192 0.0046877587 1.882181e-01 3.114969e-01 X 107716690 107717135 446 - 2.580 2.663 0.277
ENSG00000157514 E016 49.5034955 0.0059558051 2.166166e-10 3.604829e-09 X 107721859 107722272 414 - 1.871 1.503 -1.250
ENSG00000157514 E017 0.0000000       X 107759496 107759686 191 -      
ENSG00000157514 E018 67.1898034 0.0004018233 6.638247e-09 8.460114e-08 X 107775100 107775117 18 - 1.916 1.677 -0.806
ENSG00000157514 E019 92.2978971 0.0003305092 1.277645e-12 3.079466e-11 X 107775118 107775166 49 - 2.058 1.806 -0.848
ENSG00000157514 E020 91.1666437 0.0013249904 4.552752e-11 8.506808e-10 X 107775167 107775245 79 - 2.051 1.799 -0.847
ENSG00000157514 E021 73.7041041 0.0022319294 4.466100e-08 4.864539e-07 X 107775246 107775294 49 - 1.950 1.711 -0.807
ENSG00000157514 E022 121.7253706 0.0013286245 9.429124e-08 9.618865e-07 X 107775295 107775511 217 - 2.122 1.946 -0.588
ENSG00000157514 E023 32.2927139 0.0006621547 6.152840e-04 2.589269e-03 X 107775512 107775525 14 - 1.573 1.374 -0.682
ENSG00000157514 E024 48.9094112 0.0004862107 1.016693e-06 8.418617e-06 X 107775526 107775779 254 - 1.775 1.540 -0.799
ENSG00000157514 E025 43.2065590 0.0112348123 8.216310e-03 2.433182e-02 X 107775780 107775988 209 - 1.674 1.501 -0.590
ENSG00000157514 E026 1.2554477 0.0100698012 6.367389e-02 1.328169e-01 X 107776003 107776145 143 - 0.540 0.227 -1.845
ENSG00000157514 E027 1.6585973 0.0091320969 1.584931e-01 2.731081e-01 X 107776146 107776343 198 - 0.540 0.308 -1.258
ENSG00000157514 E028 2.1713303 0.0072438620 8.020537e-01 8.738924e-01 X 107776344 107776388 45 - 0.455 0.434 -0.107
ENSG00000157514 E029 0.8898608 0.2545919223 4.179009e-01 5.612152e-01 X 107776583 107776598 16 - 0.349 0.219 -0.908
ENSG00000157514 E030 0.7383454 0.4351890131 8.245996e-01 8.895173e-01 X 107776599 107776714 116 - 0.208 0.216 0.066
ENSG00000157514 E031 1.8402886 0.0077851382 2.217323e-01 3.524658e-01 X 107776970 107777019 50 - 0.540 0.343 -1.036
ENSG00000157514 E032 6.7047844 0.1057349872 5.322680e-02 1.148951e-01 X 107777020 107777184 165 - 1.035 0.721 -1.209
ENSG00000157514 E033 1.2940426 0.0104911184 2.645878e-01 4.025552e-01 X 107777185 107777271 87 - 0.455 0.269 -1.108
ENSG00000157514 E034 1.0694769 0.0121989077 3.407848e-02 7.991028e-02 X 107777272 107777342 71 - 0.540 0.180 -2.260