ENSG00000157510

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296721 ENSG00000157510 HEK293_OSMI2_2hA HEK293_TMG_2hB AFAP1L1 protein_coding protein_coding 2.809195 4.222978 2.36348 0.3682769 0.2663366 -0.8346692 1.47357251 1.897358 1.3554868 0.1258693 0.06612469 -0.4821606 0.56158750 0.4524667 0.59290000 0.14043333 0.469509168 0.008756389 FALSE TRUE
ENST00000455574 ENSG00000157510 HEK293_OSMI2_2hA HEK293_TMG_2hB AFAP1L1 protein_coding retained_intron 2.809195 4.222978 2.36348 0.3682769 0.2663366 -0.8346692 1.18547742 2.266648 0.5461187 0.2956209 0.22266543 -2.0334465 0.37452917 0.5335667 0.21660000 -0.31696667 0.008756389 0.008756389 FALSE TRUE
ENST00000508444 ENSG00000157510 HEK293_OSMI2_2hA HEK293_TMG_2hB AFAP1L1 protein_coding retained_intron 2.809195 4.222978 2.36348 0.3682769 0.2663366 -0.8346692 0.06297073 0.000000 0.2310752 0.0000000 0.11554060 4.5914114 0.02500417 0.0000000 0.09243333 0.09243333 0.090590987 0.008756389   FALSE
ENST00000522492 ENSG00000157510 HEK293_OSMI2_2hA HEK293_TMG_2hB AFAP1L1 protein_coding processed_transcript 2.809195 4.222978 2.36348 0.3682769 0.2663366 -0.8346692 0.04005272 0.000000 0.1858508 0.0000000 0.09759365 4.2916833 0.01854583 0.0000000 0.08140000 0.08140000 0.113057018 0.008756389 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157510 E001 2.0253064 0.0069812466 0.0003288566 0.001496359 5 149271859 149271870 12 + 0.764 0.172 -3.309
ENSG00000157510 E002 3.3830509 0.0110160692 0.0013657788 0.005195324 5 149271871 149271894 24 + 0.878 0.390 -2.169
ENSG00000157510 E003 5.4008897 0.0972267971 0.1574480351 0.271710053 5 149271895 149271918 24 + 0.926 0.675 -0.991
ENSG00000157510 E004 9.2401536 0.0020897681 0.3593307353 0.503670794 5 149271919 149271984 66 + 1.043 0.942 -0.373
ENSG00000157510 E005 19.8411540 0.0085662166 0.8836469426 0.929584157 5 149299509 149299637 129 + 1.277 1.285 0.028
ENSG00000157510 E006 21.8033612 0.0008625956 0.3792176740 0.523493647 5 149300271 149300354 84 + 1.287 1.353 0.232
ENSG00000157510 E007 19.7720596 0.0100800818 0.7876710198 0.863972716 5 149301133 149301190 58 + 1.277 1.302 0.087
ENSG00000157510 E008 17.3428672 0.0304289508 0.5968417159 0.718711648 5 149301191 149301230 40 + 1.277 1.220 -0.203
ENSG00000157510 E009 28.5533896 0.0045107603 0.6027295236 0.723656283 5 149302418 149302526 109 + 1.468 1.430 -0.133
ENSG00000157510 E010 0.4741261 0.0210624966 0.2841458813 0.424354054 5 149302527 149302668 142 + 0.273 0.094 -1.850
ENSG00000157510 E011 0.2987644 0.0273324090 0.0857107429   5 149304271 149304320 50 + 0.273 0.000 -12.220
ENSG00000157510 E012 22.1567554 0.0267071266 0.9742303597 0.987930002 5 149306306 149306404 99 + 1.333 1.341 0.027
ENSG00000157510 E013 39.0400132 0.0009510871 0.0228965394 0.057525870 5 149307402 149307613 212 + 1.475 1.610 0.463
ENSG00000157510 E014 45.5426641 0.0014281958 0.0099059033 0.028531928 5 149309956 149310135 180 + 1.534 1.679 0.493
ENSG00000157510 E015 31.4167042 0.0008538020 0.7434321347 0.832066529 5 149312112 149312204 93 + 1.500 1.478 -0.074
ENSG00000157510 E016 6.3006594 0.0245471592 0.0003707438 0.001661258 5 149312205 149312375 171 + 0.364 0.971 2.673
ENSG00000157510 E017 0.5911862 0.0184130766 0.0084195137 0.024837303 5 149315640 149315820 181 + 0.439 0.000 -13.204
ENSG00000157510 E018 17.8139869 0.0011385918 0.0107920489 0.030667206 5 149315821 149315914 94 + 1.375 1.171 -0.718
ENSG00000157510 E019 19.7581712 0.0015771063 0.0543092023 0.116787163 5 149316151 149316303 153 + 1.391 1.242 -0.519
ENSG00000157510 E020 21.3700953 0.0227049722 0.0955778413 0.183759593 5 149317729 149317940 212 + 1.428 1.264 -0.570
ENSG00000157510 E021 18.9401892 0.0075195341 0.3368532738 0.480714732 5 149319582 149319727 146 + 1.324 1.237 -0.306
ENSG00000157510 E022 12.7139812 0.0026901959 0.3624133105 0.506817903 5 149320391 149320463 73 + 1.043 1.134 0.326
ENSG00000157510 E023 15.5419484 0.0011872196 0.5812646685 0.705826706 5 149322606 149322717 112 + 1.163 1.211 0.172
ENSG00000157510 E024 27.6230378 0.0007803510 0.4474783065 0.588859873 5 149329666 149329830 165 + 1.391 1.442 0.176
ENSG00000157510 E025 28.6803962 0.0141379929 0.6875206790 0.789850579 5 149332695 149332873 179 + 1.421 1.452 0.108
ENSG00000157510 E026 29.0733191 0.0039442768 0.7935638803 0.868008462 5 149335594 149335722 129 + 1.462 1.441 -0.071
ENSG00000157510 E027 148.4119454 0.0076346812 0.7033065587 0.802002880 5 149340007 149343637 3631 + 2.135 2.150 0.050