ENSG00000157502

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337685 ENSG00000157502 HEK293_OSMI2_2hA HEK293_TMG_2hB PWWP3B protein_coding protein_coding 0.9783214 0.3671628 1.462769 0.009029657 0.09280661 1.965272 0.06208122 0.1219919 0.08728429 0.1219919 0.08728429 -0.440171 0.11915000 0.3333333 0.05556667 -0.27776667 0.893674472 0.007594944 FALSE TRUE
ENST00000357175 ENSG00000157502 HEK293_OSMI2_2hA HEK293_TMG_2hB PWWP3B protein_coding protein_coding 0.9783214 0.3671628 1.462769 0.009029657 0.09280661 1.965272 0.62329858 0.0000000 0.89286447 0.0000000 0.27823533 6.496438 0.49421250 0.0000000 0.60013333 0.60013333 0.007594944 0.007594944 FALSE TRUE
ENST00000372552 ENSG00000157502 HEK293_OSMI2_2hA HEK293_TMG_2hB PWWP3B protein_coding protein_coding 0.9783214 0.3671628 1.462769 0.009029657 0.09280661 1.965272 0.12079917 0.2451709 0.07914562 0.1229161 0.07914562 -1.517228 0.19615833 0.6666667 0.06193333 -0.60473333 0.329281155 0.007594944 FALSE TRUE
MSTRG.34670.3 ENSG00000157502 HEK293_OSMI2_2hA HEK293_TMG_2hB PWWP3B protein_coding   0.9783214 0.3671628 1.462769 0.009029657 0.09280661 1.965272 0.10139484 0.0000000 0.36982490 0.0000000 0.18622449 5.247263 0.09524167 0.0000000 0.26050000 0.26050000 0.424999322 0.007594944 FALSE TRUE
MSTRG.34670.4 ENSG00000157502 HEK293_OSMI2_2hA HEK293_TMG_2hB PWWP3B protein_coding   0.9783214 0.3671628 1.462769 0.009029657 0.09280661 1.965272 0.07074763 0.0000000 0.03364973 0.0000000 0.03364973 2.125973 0.09523750 0.0000000 0.02186667 0.02186667 1.000000000 0.007594944 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157502 E001 0.2966881 0.0290785164 1.000000000   X 106168305 106168318 14 + 0.124 0.000 -9.485
ENSG00000157502 E002 2.2393793 0.0262417765 0.143257266 0.25245960 X 106168319 106168366 48 + 0.521 0.214 -1.862
ENSG00000157502 E003 2.7177718 0.0392948841 0.316156398 0.45891270 X 106168367 106168425 59 + 0.563 0.358 -1.053
ENSG00000157502 E004 5.1058230 0.0033531321 0.166129931 0.28317153 X 106171012 106171139 128 + 0.777 0.551 -0.964
ENSG00000157502 E005 0.5149242 0.1653480366 0.110816759 0.20674278 X 106177224 106177359 136 + 0.067 0.358 2.948
ENSG00000157502 E006 0.1482932 0.0421905708 0.112693847   X 106201736 106201769 34 + 0.000 0.214 11.679
ENSG00000157502 E007 1.9367272 0.0130456698 0.201274316 0.32778144 X 106203985 106203989 5 + 0.476 0.214 -1.643
ENSG00000157502 E008 6.2664254 0.0029352401 0.013555304 0.03720465 X 106203990 106204170 181 + 0.873 0.465 -1.757
ENSG00000157502 E009 83.8187508 0.0005215405 0.001448139 0.00546734 X 106205219 106208956 3738 + 1.845 1.904 0.198