ENSG00000157500

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288266 ENSG00000157500 HEK293_OSMI2_2hA HEK293_TMG_2hB APPL1 protein_coding protein_coding 16.10701 4.278382 27.19216 0.07791744 0.9796503 2.665216 9.6955283 3.34073464 16.279404 0.23946370 0.7767345 2.281384 0.65772083 0.78336667 0.59826667 -0.18510000 1.442624e-01 4.378e-08 FALSE TRUE
MSTRG.23134.3 ENSG00000157500 HEK293_OSMI2_2hA HEK293_TMG_2hB APPL1 protein_coding   16.10701 4.278382 27.19216 0.07791744 0.9796503 2.665216 0.8663739 0.26742621 2.663005 0.18905812 0.3012368 3.268286 0.05190000 0.06126667 0.09750000 0.03623333 5.890800e-01 4.378e-08 FALSE TRUE
MSTRG.23134.4 ENSG00000157500 HEK293_OSMI2_2hA HEK293_TMG_2hB APPL1 protein_coding   16.10701 4.278382 27.19216 0.07791744 0.9796503 2.665216 1.0974306 0.06664075 1.962257 0.06664075 1.9622568 4.685592 0.05385000 0.01603333 0.06813333 0.05210000 8.306650e-01 4.378e-08 FALSE TRUE
MSTRG.23134.6 ENSG00000157500 HEK293_OSMI2_2hA HEK293_TMG_2hB APPL1 protein_coding   16.10701 4.278382 27.19216 0.07791744 0.9796503 2.665216 0.8903300 0.00000000 2.774705 0.00000000 0.3649646 8.121381 0.03974583 0.00000000 0.10320000 0.10320000 4.378000e-08 4.378e-08 FALSE TRUE
MSTRG.23134.8 ENSG00000157500 HEK293_OSMI2_2hA HEK293_TMG_2hB APPL1 protein_coding   16.10701 4.278382 27.19216 0.07791744 0.9796503 2.665216 2.6428089 0.36337145 2.766889 0.20654161 1.4408316 2.894786 0.11940417 0.08326667 0.10563333 0.02236667 1.000000e+00 4.378e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157500 E001 0.0000000       3 57227726 57227728 3 +      
ENSG00000157500 E002 3.3894863 0.0050113823 9.776029e-03 2.821149e-02 3 57227729 57227788 60 + 0.606 0.000 -15.538
ENSG00000157500 E003 13.0553864 0.0016741446 1.130775e-03 4.407043e-03 3 57227789 57227830 42 + 1.078 0.624 -1.774
ENSG00000157500 E004 13.8022406 0.0022355704 6.074958e-04 2.560532e-03 3 57227831 57227838 8 + 1.101 0.624 -1.858
ENSG00000157500 E005 24.5984749 0.0022288224 3.765710e-03 1.248408e-02 3 57227839 57227873 35 + 1.318 1.058 -0.927
ENSG00000157500 E006 23.9030279 0.0008238935 1.112511e-02 3.146545e-02 3 57227874 57227875 2 + 1.302 1.087 -0.762
ENSG00000157500 E007 42.3647317 0.0046602106 1.121458e-02 3.168113e-02 3 57227876 57227937 62 + 1.534 1.371 -0.561
ENSG00000157500 E008 4.4498668 0.0073209116 2.737677e-03 9.485958e-03 3 57230714 57230767 54 + 0.696 0.000 -15.916
ENSG00000157500 E009 62.7070317 0.0047354453 2.123296e-03 7.606146e-03 3 57235566 57235664 99 + 1.702 1.530 -0.584
ENSG00000157500 E010 57.9962471 0.0012192001 1.908219e-03 6.941498e-03 3 57237492 57237551 60 + 1.668 1.509 -0.545
ENSG00000157500 E011 68.7786030 0.0003718614 1.474298e-04 7.360496e-04 3 57238045 57238116 72 + 1.744 1.559 -0.627
ENSG00000157500 E012 0.0000000       3 57238117 57238205 89 +      
ENSG00000157500 E013 86.5274105 0.0003509226 8.818689e-05 4.664733e-04 3 57240465 57240552 88 + 1.840 1.676 -0.553
ENSG00000157500 E014 67.4183428 0.0004266923 2.457536e-05 1.493561e-04 3 57242101 57242142 42 + 1.739 1.519 -0.746
ENSG00000157500 E015 84.9471024 0.0003538770 1.972130e-07 1.891430e-06 3 57242856 57242914 59 + 1.840 1.587 -0.856
ENSG00000157500 E016 123.7997392 0.0002674218 1.834032e-07 1.770636e-06 3 57246076 57246222 147 + 1.995 1.803 -0.647
ENSG00000157500 E017 89.6137867 0.0013948572 3.662323e-06 2.689209e-05 3 57247395 57247477 83 + 1.859 1.639 -0.744
ENSG00000157500 E018 132.9199740 0.0063606633 1.136227e-03 4.425013e-03 3 57248193 57248351 159 + 2.019 1.880 -0.465
ENSG00000157500 E019 140.1983355 0.0013783965 3.493729e-02 8.153497e-02 3 57249360 57249548 189 + 2.028 1.988 -0.134
ENSG00000157500 E020 67.2945323 0.0004052383 2.036371e-01 3.307618e-01 3 57252269 57252311 43 + 1.712 1.691 -0.070
ENSG00000157500 E021 64.1296277 0.0004290727 3.841568e-01 5.283292e-01 3 57253682 57253738 57 + 1.689 1.691 0.008
ENSG00000157500 E022 76.7762033 0.0003816413 9.434741e-01 9.685405e-01 3 57256957 57257051 95 + 1.758 1.808 0.169
ENSG00000157500 E023 127.6057803 0.0015844358 7.745519e-01 8.546996e-01 3 57257246 57257428 183 + 1.969 2.036 0.222
ENSG00000157500 E024 0.3030308 0.3935861950 1.000000e+00   3 57258763 57259027 265 + 0.102 0.000 -12.017
ENSG00000157500 E025 86.9806497 0.0033102320 1.929142e-01 3.174302e-01 3 57259028 57259080 53 + 1.821 1.798 -0.078
ENSG00000157500 E026 0.1515154 0.0432905346 1.000000e+00   3 57259793 57259844 52 + 0.054 0.000 -11.010
ENSG00000157500 E027 132.3152268 0.0002544788 7.961255e-01 8.698311e-01 3 57259845 57260019 175 + 1.986 2.051 0.216
ENSG00000157500 E028 86.9157592 0.0003088374 5.286560e-01 6.615672e-01 3 57260117 57260153 37 + 1.803 1.887 0.285
ENSG00000157500 E029 0.9212829 0.0233104517 2.630100e-02 6.455237e-02 3 57260154 57260439 286 + 0.102 0.533 3.191
ENSG00000157500 E030 154.8139969 0.0008356670 4.880682e-01 6.256844e-01 3 57260628 57260774 147 + 2.052 2.132 0.270
ENSG00000157500 E031 116.3515207 0.0004221838 1.457819e-02 3.954064e-02 3 57267742 57267792 51 + 1.914 2.069 0.518
ENSG00000157500 E032 1.4790604 0.0091177338 1.308458e-01 2.353265e-01 3 57267793 57268021 229 + 0.366 0.000 -14.331
ENSG00000157500 E033 147.8161978 0.0002551121 1.011927e-02 2.905526e-02 3 57268398 57268487 90 + 2.020 2.167 0.493
ENSG00000157500 E034 155.0155265 0.0003268582 7.445569e-03 2.237533e-02 3 57269541 57269700 160 + 2.036 2.186 0.500
ENSG00000157500 E035 86.2119534 0.0047163836 2.897825e-02 6.996371e-02 3 57269701 57269751 51 + 1.776 1.952 0.595
ENSG00000157500 E036 881.6720108 0.0161121000 2.466345e-03 8.663050e-03 3 57269752 57273471 3720 + 2.778 2.977 0.661
ENSG00000157500 E037 1.9970920 0.0068614373 4.969587e-01 6.335280e-01 3 57276304 57276459 156 + 0.366 0.532 0.863
ENSG00000157500 E038 9.7234810 0.0017935670 5.206086e-02 1.128219e-01 3 57277793 57278105 313 + 0.858 1.140 1.045
ENSG00000157500 E039 6.9386334 0.0024664870 3.120165e-03 1.061975e-02 3 57287597 57287770 174 + 0.684 1.115 1.649