ENSG00000157483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288235 ENSG00000157483 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO1E protein_coding protein_coding 8.089974 9.699449 8.945162 0.95581 1.035097 -0.1166699 2.0620126 2.6825989 2.0864970 0.1301904 0.03466831 -0.3610186 0.27106250 0.2798667 0.23920000 -0.04066667 6.367208e-01 2.438797e-07 FALSE TRUE
ENST00000558182 ENSG00000157483 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO1E protein_coding processed_transcript 8.089974 9.699449 8.945162 0.95581 1.035097 -0.1166699 0.2153482 0.0000000 0.6460066 0.0000000 0.64600661 6.0356384 0.02261667 0.0000000 0.06040000 0.06040000 8.181231e-01 2.438797e-07 FALSE FALSE
ENST00000559269 ENSG00000157483 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO1E protein_coding protein_coding 8.089974 9.699449 8.945162 0.95581 1.035097 -0.1166699 0.7878787 0.2594418 1.9197706 0.2594418 0.30559028 2.8403836 0.09465833 0.0245000 0.21700000 0.19250000 4.714173e-02 2.438797e-07 FALSE FALSE
ENST00000559412 ENSG00000157483 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO1E protein_coding protein_coding 8.089974 9.699449 8.945162 0.95581 1.035097 -0.1166699 2.0146616 4.0951814 0.9469313 0.5383336 0.51554231 -2.1009588 0.22937917 0.4210000 0.09466667 -0.32633333 2.414520e-01 2.438797e-07 FALSE FALSE
ENST00000560749 ENSG00000157483 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO1E protein_coding protein_coding 8.089974 9.699449 8.945162 0.95581 1.035097 -0.1166699 0.5488080 1.3039028 0.0000000 0.4198210 0.00000000 -7.0377148 0.05978750 0.1369333 0.00000000 -0.13693333 2.438797e-07 2.438797e-07 FALSE TRUE
MSTRG.10938.4 ENSG00000157483 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO1E protein_coding   8.089974 9.699449 8.945162 0.95581 1.035097 -0.1166699 2.4206322 1.3583241 3.3459567 0.4772979 0.15957082 1.2943141 0.31628750 0.1376667 0.38876667 0.25110000 1.974044e-02 2.438797e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157483 E001 20.4538307 0.0192702410 6.434841e-01 7.560211e-01 15 59132434 59136365 3932 - 1.343 1.301 -0.149
ENSG00000157483 E002 70.8485798 0.0116229644 1.288619e-09 1.871837e-08 15 59136366 59136777 412 - 1.563 1.988 1.439
ENSG00000157483 E003 183.1192124 0.0013942828 5.397991e-11 9.962331e-10 15 59136778 59137456 679 - 2.132 2.339 0.691
ENSG00000157483 E004 56.4253880 0.0006989216 2.990268e-02 7.176938e-02 15 59138198 59138291 94 - 1.693 1.803 0.374
ENSG00000157483 E005 48.5712830 0.0006448568 1.502124e-01 2.619632e-01 15 59138292 59138367 76 - 1.648 1.728 0.272
ENSG00000157483 E006 86.3751301 0.0003130098 5.678786e-01 6.946300e-01 15 59153590 59153791 202 - 1.921 1.950 0.096
ENSG00000157483 E007 54.9738031 0.0004266107 3.993154e-01 5.430505e-01 15 59158287 59158379 93 - 1.765 1.733 -0.108
ENSG00000157483 E008 56.5170720 0.0004087966 8.742587e-01 9.231497e-01 15 59161073 59161230 158 - 1.750 1.764 0.049
ENSG00000157483 E009 43.5395849 0.0005427373 2.924162e-02 7.047204e-02 15 59163157 59163218 62 - 1.571 1.695 0.422
ENSG00000157483 E010 54.9613515 0.0004866743 4.713969e-02 1.040726e-01 15 59163219 59163303 85 - 1.680 1.782 0.345
ENSG00000157483 E011 73.0614936 0.0019991246 1.389050e-01 2.465904e-01 15 59171897 59172042 146 - 1.823 1.897 0.249
ENSG00000157483 E012 73.8552932 0.0018115054 5.995201e-01 7.208968e-01 15 59173746 59173915 170 - 1.855 1.886 0.104
ENSG00000157483 E013 53.9124962 0.0008498556 7.479653e-01 8.353610e-01 15 59174126 59174240 115 - 1.725 1.748 0.077
ENSG00000157483 E014 32.6688463 0.0006630925 2.947446e-01 4.358533e-01 15 59178393 59178423 31 - 1.482 1.553 0.243
ENSG00000157483 E015 51.3283111 0.0007983692 3.828937e-01 5.270665e-01 15 59178424 59178537 114 - 1.690 1.740 0.172
ENSG00000157483 E016 50.1451716 0.0004940716 4.124335e-01 5.559775e-01 15 59188118 59188216 99 - 1.725 1.692 -0.111
ENSG00000157483 E017 40.1801139 0.0006299310 8.562012e-02 1.683875e-01 15 59195461 59195496 36 - 1.658 1.571 -0.296
ENSG00000157483 E018 40.1926856 0.0006317521 8.560050e-02 1.683616e-01 15 59195497 59195567 71 - 1.658 1.571 -0.296
ENSG00000157483 E019 38.7009796 0.0063562084 8.212733e-01 8.873236e-01 15 59202326 59202407 82 - 1.579 1.597 0.062
ENSG00000157483 E020 34.9643207 0.0018660263 2.807660e-01 4.206427e-01 15 59205400 59205485 86 - 1.506 1.578 0.248
ENSG00000157483 E021 0.4428904 0.6601151374 3.929972e-01 5.368938e-01 15 59206706 59206761 56 - 0.000 0.220 10.806
ENSG00000157483 E022 40.3866660 0.0011987353 3.209925e-01 4.641783e-01 15 59208681 59208808 128 - 1.575 1.637 0.213
ENSG00000157483 E023 22.9200246 0.0102970679 8.498148e-01 9.068089e-01 15 59208809 59208848 40 - 1.382 1.369 -0.043
ENSG00000157483 E024 0.1482932 0.0414597451 5.451085e-01   15 59208849 59209000 152 - 0.000 0.116 11.219
ENSG00000157483 E025 31.6566520 0.0024382241 4.056207e-01 5.492966e-01 15 59210514 59210600 87 - 1.541 1.496 -0.155
ENSG00000157483 E026 27.9512560 0.0007565210 2.751989e-01 4.144785e-01 15 59214228 59214314 87 - 1.496 1.433 -0.218
ENSG00000157483 E027 24.9289220 0.0023598973 8.375329e-01 8.984211e-01 15 59214640 59214720 81 - 1.400 1.423 0.077
ENSG00000157483 E028 44.5480004 0.0005590300 1.367776e-02 3.749020e-02 15 59217891 59218060 170 - 1.722 1.602 -0.408
ENSG00000157483 E029 26.3912250 0.0007810431 4.525482e-02 1.006574e-01 15 59218061 59218087 27 - 1.506 1.381 -0.431
ENSG00000157483 E030 0.0000000       15 59218227 59218296 70 -      
ENSG00000157483 E031 51.4252899 0.0004583488 2.959338e-05 1.763677e-04 15 59223059 59223191 133 - 1.818 1.625 -0.656
ENSG00000157483 E032 52.8754997 0.0037099997 7.890905e-04 3.220328e-03 15 59224689 59224823 135 - 1.821 1.643 -0.600
ENSG00000157483 E033 26.6366182 0.0007780642 3.791310e-02 8.718241e-02 15 59227459 59227482 24 - 1.510 1.381 -0.447
ENSG00000157483 E034 38.1958625 0.0031229120 1.005008e-02 2.888461e-02 15 59227483 59227590 108 - 1.668 1.518 -0.510
ENSG00000157483 E035 32.9029313 0.0006752654 1.687515e-02 4.465674e-02 15 59231702 59231791 90 - 1.598 1.462 -0.467
ENSG00000157483 E036 31.0617602 0.0006832648 4.621603e-03 1.487965e-02 15 59236585 59236672 88 - 1.586 1.418 -0.578
ENSG00000157483 E037 35.0280308 0.0059495929 2.589825e-02 6.373532e-02 15 59256284 59256378 95 - 1.627 1.481 -0.502
ENSG00000157483 E038 34.2363472 0.0056394181 8.394524e-04 3.399785e-03 15 59261420 59261509 90 - 1.655 1.433 -0.757
ENSG00000157483 E039 0.0000000       15 59264903 59264997 95 -      
ENSG00000157483 E040 0.1482932 0.0414597451 5.451085e-01   15 59272246 59272305 60 - 0.000 0.116 11.219
ENSG00000157483 E041 37.4580917 0.0006613475 1.272449e-05 8.252903e-05 15 59272306 59272449 144 - 1.702 1.462 -0.819
ENSG00000157483 E042 37.7782738 0.0104537502 1.077077e-03 4.224967e-03 15 59372498 59372871 374 - 1.704 1.470 -0.799