ENSG00000157470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288228 ENSG00000157470 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM81A protein_coding protein_coding 3.124678 3.717914 3.663909 0.2928843 0.4068027 -0.02105257 0.8328556 0.5346780 0.9699285 0.04539372 0.11266358 0.8472729 0.26914167 0.1468000 0.26480000 0.118000000 0.03649369 0.03649369 FALSE TRUE
ENST00000557895 ENSG00000157470 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM81A protein_coding processed_transcript 3.124678 3.717914 3.663909 0.2928843 0.4068027 -0.02105257 0.1845221 0.3911268 0.2766349 0.17515078 0.18399690 -0.4848443 0.05388333 0.1095333 0.08403333 -0.025500000 0.78829982 0.03649369   FALSE
ENST00000558513 ENSG00000157470 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM81A protein_coding retained_intron 3.124678 3.717914 3.663909 0.2928843 0.4068027 -0.02105257 0.3772238 0.5844375 0.4622839 0.07697359 0.07002699 -0.3318708 0.11856667 0.1563000 0.12523333 -0.031066667 0.67588368 0.03649369 FALSE TRUE
ENST00000558900 ENSG00000157470 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM81A protein_coding retained_intron 3.124678 3.717914 3.663909 0.2928843 0.4068027 -0.02105257 0.4112271 0.5577249 0.5016465 0.23464767 0.18724838 -0.1500448 0.12965833 0.1425333 0.13626667 -0.006266667 0.96715578 0.03649369 FALSE FALSE
ENST00000559628 ENSG00000157470 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM81A protein_coding protein_coding 3.124678 3.717914 3.663909 0.2928843 0.4068027 -0.02105257 0.2342130 0.4813552 0.4218454 0.09322191 0.12236597 -0.1862515 0.07342083 0.1272333 0.11066667 -0.016566667 0.84182492 0.03649369   FALSE
ENST00000560118 ENSG00000157470 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM81A protein_coding processed_transcript 3.124678 3.717914 3.663909 0.2928843 0.4068027 -0.02105257 0.6515442 0.9671366 0.4959580 0.19301611 0.06901013 -0.9495428 0.21947917 0.2662333 0.13590000 -0.130333333 0.23432344 0.03649369   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157470 E001 0.5858876 0.020405458 0.3378691597 0.481747151 15 59372693 59372779 87 + 0.293 0.124 -1.547
ENSG00000157470 E002 0.1482932 0.041706870 0.4658142567   15 59372995 59373091 97 + 0.000 0.124 9.958
ENSG00000157470 E003 0.0000000       15 59402276 59402358 83 +      
ENSG00000157470 E004 1.4360948 0.009561799 0.7979343710 0.871079543 15 59438186 59438200 15 + 0.416 0.365 -0.283
ENSG00000157470 E005 1.7660924 0.008162342 0.7043315402 0.802892439 15 59438201 59438204 4 + 0.416 0.474 0.302
ENSG00000157470 E006 4.2653319 0.004057410 0.1936699983 0.318394586 15 59438205 59438230 26 + 0.624 0.798 0.717
ENSG00000157470 E007 5.7025726 0.002995949 0.5119502726 0.646877711 15 59438231 59438244 14 + 0.788 0.861 0.287
ENSG00000157470 E008 6.8128476 0.002577171 0.4356497470 0.577859853 15 59438245 59438260 16 + 0.851 0.934 0.314
ENSG00000157470 E009 7.2922842 0.002473176 0.3598986624 0.504212072 15 59438261 59438282 22 + 0.870 0.966 0.360
ENSG00000157470 E010 0.1472490 0.047585273 0.5124456409   15 59438464 59438495 32 + 0.121 0.000 -10.705
ENSG00000157470 E011 0.1472490 0.047585273 0.5124456409   15 59438496 59438630 135 + 0.121 0.000 -10.705
ENSG00000157470 E012 5.1092956 0.003449044 0.0480128792 0.105656889 15 59439024 59439064 41 + 0.624 0.881 1.040
ENSG00000157470 E013 0.0000000       15 59439954 59439954 1 +      
ENSG00000157470 E014 7.4512843 0.006390857 0.0516450396 0.112084841 15 59439955 59440033 79 + 0.788 1.010 0.847
ENSG00000157470 E015 9.6280018 0.002129184 0.0528156511 0.114162435 15 59440034 59440123 90 + 0.906 1.099 0.710
ENSG00000157470 E016 1.0027668 0.013545017 0.3806666249 0.524943041 15 59443990 59444310 321 + 0.215 0.365 1.038
ENSG00000157470 E017 0.6632174 0.019153182 0.2907253935 0.431523625 15 59445106 59445148 43 + 0.121 0.299 1.623
ENSG00000157470 E018 0.8115105 0.015307589 0.1546606239 0.267959131 15 59445149 59445163 15 + 0.121 0.365 2.037
ENSG00000157470 E019 2.1723624 0.006990159 0.1391915683 0.246950974 15 59445164 59445208 45 + 0.359 0.599 1.209
ENSG00000157470 E020 6.8825844 0.002653481 0.0004441582 0.001944307 15 59445209 59445262 54 + 0.624 1.050 1.671
ENSG00000157470 E021 4.8126100 0.003649382 0.2883389036 0.428915326 15 59445263 59445568 306 + 0.686 0.820 0.542
ENSG00000157470 E022 3.7986813 0.004527528 0.2458738517 0.381107186 15 59446432 59446564 133 + 0.590 0.749 0.676
ENSG00000157470 E023 6.2247412 0.006125785 0.0235502032 0.058884677 15 59446565 59446681 117 + 0.686 0.966 1.098
ENSG00000157470 E024 5.2391600 0.003305072 0.2828885845 0.422950029 15 59458550 59458617 68 + 0.870 0.723 -0.583
ENSG00000157470 E025 4.5212350 0.003974508 0.6132800265 0.732019654 15 59458618 59458646 29 + 0.714 0.774 0.245
ENSG00000157470 E026 16.6382666 0.001388287 0.5249572915 0.658379954 15 59459933 59460206 274 + 1.278 1.218 -0.213
ENSG00000157470 E027 8.7368947 0.002006468 0.0315180404 0.074915602 15 59460207 59460640 434 + 0.851 1.075 0.836
ENSG00000157470 E028 8.0039286 0.002310479 0.2667598627 0.405004413 15 59492271 59492389 119 + 1.013 0.881 -0.496
ENSG00000157470 E029 7.7898466 0.002410563 0.0470037800 0.103833587 15 59507213 59507342 130 + 1.052 0.820 -0.873
ENSG00000157470 E030 9.2185848 0.002053844 0.0004361947 0.001913530 15 59508863 59508969 107 + 1.180 0.798 -1.421
ENSG00000157470 E031 9.7828267 0.001797263 0.0025219568 0.008828247 15 59514289 59514424 136 + 1.180 0.861 -1.173
ENSG00000157470 E032 9.4211541 0.048582746 0.0479445029 0.105533390 15 59516645 59516840 196 + 1.152 0.843 -1.144
ENSG00000157470 E033 40.4603559 0.007989881 0.0911986085 0.177005223 15 59521254 59523555 2302 + 1.671 1.557 -0.387