ENSG00000157426

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000205214 ENSG00000157426 HEK293_OSMI2_2hA HEK293_TMG_2hB AASDH protein_coding protein_coding 3.774728 1.038036 6.516306 0.02760399 0.5607631 2.638578 0.9822586 0.5188344 1.4650515 0.109414315 0.47830763 1.4798772 0.36709167 0.49510000 0.23556667 -0.25953333 1.849180e-01 1.280778e-05 FALSE TRUE
ENST00000502617 ENSG00000157426 HEK293_OSMI2_2hA HEK293_TMG_2hB AASDH protein_coding protein_coding 3.774728 1.038036 6.516306 0.02760399 0.5607631 2.638578 0.2880206 0.0158840 0.5148373 0.009495001 0.09774482 4.3417381 0.06714167 0.01483333 0.08056667 0.06573333 6.317298e-02 1.280778e-05 FALSE TRUE
ENST00000513376 ENSG00000157426 HEK293_OSMI2_2hA HEK293_TMG_2hB AASDH protein_coding protein_coding 3.774728 1.038036 6.516306 0.02760399 0.5607631 2.638578 0.6235013 0.1889620 0.9255180 0.101523630 0.46549582 2.2332724 0.15595833 0.18740000 0.13470000 -0.05270000 9.495087e-01 1.280778e-05 FALSE TRUE
ENST00000514796 ENSG00000157426 HEK293_OSMI2_2hA HEK293_TMG_2hB AASDH protein_coding retained_intron 3.774728 1.038036 6.516306 0.02760399 0.5607631 2.638578 0.2320075 0.0000000 0.4724777 0.000000000 0.47247770 5.5923904 0.02928750 0.00000000 0.06210000 0.06210000 1.000000e+00 1.280778e-05 FALSE FALSE
ENST00000602986 ENSG00000157426 HEK293_OSMI2_2hA HEK293_TMG_2hB AASDH protein_coding protein_coding 3.774728 1.038036 6.516306 0.02760399 0.5607631 2.638578 0.5089569 0.0000000 0.9662431 0.000000000 0.15110501 6.6091685 0.09436667 0.00000000 0.14693333 0.14693333 5.843707e-05 1.280778e-05 FALSE TRUE
MSTRG.24922.1 ENSG00000157426 HEK293_OSMI2_2hA HEK293_TMG_2hB AASDH protein_coding   3.774728 1.038036 6.516306 0.02760399 0.5607631 2.638578 0.2488903 0.0000000 0.5744000 0.000000000 0.14246988 5.8688843 0.06152500 0.00000000 0.09046667 0.09046667 1.481685e-02 1.280778e-05 FALSE TRUE
MSTRG.24922.2 ENSG00000157426 HEK293_OSMI2_2hA HEK293_TMG_2hB AASDH protein_coding   3.774728 1.038036 6.516306 0.02760399 0.5607631 2.638578 0.1877480 0.2503973 0.1984049 0.020995684 0.12327023 -0.3213252 0.07100417 0.24176667 0.03273333 -0.20903333 4.161407e-02 1.280778e-05 TRUE TRUE
MSTRG.24922.8 ENSG00000157426 HEK293_OSMI2_2hA HEK293_TMG_2hB AASDH protein_coding   3.774728 1.038036 6.516306 0.02760399 0.5607631 2.638578 0.4841176 0.0000000 1.0235586 0.000000000 0.04179553 6.6914763 0.10207917 0.00000000 0.15823333 0.15823333 1.280778e-05 1.280778e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157426 E001 0.4439371 0.0215831779 7.649004e-01 8.478372e-01 4 56338156 56338276 121 - 0.161 0.001 -7.964
ENSG00000157426 E002 0.1515154 0.0433554353 1.000000e+00   4 56338277 56338286 10 - 0.060 0.000 -8.392
ENSG00000157426 E003 0.6653823 0.0172671820 6.888832e-01 7.909075e-01 4 56338287 56338289 3 - 0.161 0.233 0.664
ENSG00000157426 E004 0.6611159 0.0295212869 6.890686e-01 7.910360e-01 4 56338290 56338292 3 - 0.161 0.233 0.666
ENSG00000157426 E005 3.4579635 0.0704380659 2.864419e-02 6.929583e-02 4 56338293 56338391 99 - 0.468 0.865 1.708
ENSG00000157426 E006 53.3457533 0.0005279544 1.038010e-09 1.534992e-08 4 56338392 56338604 213 - 1.561 1.877 1.072
ENSG00000157426 E007 70.2183147 0.0004637479 2.789518e-06 2.103012e-05 4 56338605 56338791 187 - 1.709 1.927 0.736
ENSG00000157426 E008 48.1308038 0.0006010048 1.389059e-02 3.797833e-02 4 56342835 56342966 132 - 1.566 1.710 0.490
ENSG00000157426 E009 34.7876265 0.0007790292 9.687776e-05 5.074291e-04 4 56343562 56343684 123 - 1.396 1.653 0.879
ENSG00000157426 E010 31.8103212 0.0006938671 3.192772e-03 1.083437e-02 4 56345127 56345290 164 - 1.372 1.578 0.709
ENSG00000157426 E011 9.6321767 0.0077363846 3.128937e-02 7.446363e-02 4 56348928 56349262 335 - 0.992 0.657 -1.314
ENSG00000157426 E012 134.4171796 0.0002429269 8.135992e-01 8.818335e-01 4 56349263 56350058 796 - 2.036 2.045 0.029
ENSG00000157426 E013 30.5982369 0.0020106157 3.577338e-02 8.314411e-02 4 56351342 56351457 116 - 1.438 1.256 -0.635
ENSG00000157426 E014 26.6286013 0.0007673817 1.132255e-01 2.102304e-01 4 56353404 56353511 108 - 1.378 1.238 -0.487
ENSG00000157426 E015 20.4633570 0.0009262071 1.147386e-01 2.124505e-01 4 56353512 56353596 85 - 1.274 1.116 -0.561
ENSG00000157426 E016 47.4977821 0.0021824232 2.395813e-03 8.447571e-03 4 56354039 56354211 173 - 1.632 1.412 -0.755
ENSG00000157426 E017 41.4402014 0.0006090116 5.416898e-02 1.165478e-01 4 56354705 56354811 107 - 1.561 1.424 -0.472
ENSG00000157426 E018 40.9419197 0.0026222585 1.071119e-01 2.012759e-01 4 56355182 56355299 118 - 1.554 1.435 -0.408
ENSG00000157426 E019 44.7528970 0.0005396079 6.870734e-04 2.852159e-03 4 56355300 56355423 124 - 1.608 1.361 -0.849
ENSG00000157426 E020 57.3175348 0.0004886272 7.805168e-06 5.314926e-05 4 56371451 56371643 193 - 1.719 1.424 -1.009
ENSG00000157426 E021 52.1468697 0.0005749162 1.987098e-02 5.121812e-02 4 56378148 56378464 317 - 1.658 1.508 -0.512
ENSG00000157426 E022 0.2998086 0.0289557301 2.578586e-01   4 56381759 56382423 665 - 0.060 0.232 2.244
ENSG00000157426 E023 0.2998086 0.0289557301 2.578586e-01   4 56382424 56382476 53 - 0.060 0.232 2.244
ENSG00000157426 E024 19.2618350 0.0009904208 3.286145e-01 4.721154e-01 4 56382477 56382597 121 - 1.198 1.289 0.318
ENSG00000157426 E025 31.0484334 0.0006940203 1.600431e-01 2.751607e-01 4 56384070 56384341 272 - 1.434 1.319 -0.396
ENSG00000157426 E026 23.5388486 0.0010092127 8.405539e-02 1.658927e-01 4 56387362 56389584 2223 - 1.326 1.161 -0.581