ENSG00000157379

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288111 ENSG00000157379 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS1 protein_coding protein_coding 20.38776 28.85957 12.97733 0.7303708 1.075913 -1.152445 12.714317 22.7333566 6.8850574 0.43758249 0.44918691 -1.72181072 0.60057083 0.78853333 0.54070000 -0.24783333 0.009435761 4.985306e-06 FALSE TRUE
ENST00000559483 ENSG00000157379 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS1 protein_coding processed_transcript 20.38776 28.85957 12.97733 0.7303708 1.075913 -1.152445 1.040035 0.9829975 1.7292610 0.50885536 0.60288900 0.80861247 0.06032500 0.03323333 0.12683333 0.09360000 0.425962495 4.985306e-06 FALSE TRUE
ENST00000561273 ENSG00000157379 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS1 protein_coding retained_intron 20.38776 28.85957 12.97733 0.7303708 1.075913 -1.152445 1.002204 0.6617512 0.6113773 0.07780133 0.07228844 -0.11245745 0.05553333 0.02280000 0.04876667 0.02596667 0.091488401 4.985306e-06 TRUE TRUE
ENST00000561281 ENSG00000157379 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS1 protein_coding retained_intron 20.38776 28.85957 12.97733 0.7303708 1.075913 -1.152445 1.370422 0.8272419 0.7902737 0.30787375 0.23747251 -0.06515106 0.07225000 0.02840000 0.05883333 0.03043333 0.404353609 4.985306e-06   FALSE
MSTRG.9254.2 ENSG00000157379 HEK293_OSMI2_2hA HEK293_TMG_2hB DHRS1 protein_coding   20.38776 28.85957 12.97733 0.7303708 1.075913 -1.152445 1.245057 2.0056950 0.4486908 0.26416553 0.27605068 -2.13568332 0.05501667 0.06986667 0.03846667 -0.03140000 0.572917861 4.985306e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157379 E001 0.3030308 0.3878423060 8.042903e-02   14 24289220 24290597 1378 - 0.324 0.000 -12.370
ENSG00000157379 E002 3.3806773 0.0047781208 1.945927e-02 5.032970e-02 14 24290598 24290599 2 - 0.191 0.649 2.649
ENSG00000157379 E003 3.3806773 0.0047781208 1.945927e-02 5.032970e-02 14 24290600 24290602 3 - 0.191 0.649 2.649
ENSG00000157379 E004 12.7749700 0.0016869757 4.731290e-02 1.043923e-01 14 24290603 24290635 33 - 0.882 1.117 0.870
ENSG00000157379 E005 225.0123615 0.0060112513 3.798690e-03 1.257800e-02 14 24290636 24290995 360 - 2.170 2.303 0.441
ENSG00000157379 E006 2.9579253 0.0052333753 8.861778e-02 1.730125e-01 14 24290996 24291125 130 - 0.733 0.465 -1.199
ENSG00000157379 E007 130.9226477 0.0038460003 1.716546e-01 2.903738e-01 14 24291139 24291219 81 - 1.991 2.058 0.223
ENSG00000157379 E008 17.6551578 0.0584389640 1.366771e-02 3.746809e-02 14 24291220 24291555 336 - 1.439 1.097 -1.204
ENSG00000157379 E009 80.4874908 0.0024149305 7.175949e-02 1.462762e-01 14 24291556 24291625 70 - 1.753 1.851 0.328
ENSG00000157379 E010 11.3554132 0.0489832639 7.700387e-03 2.302677e-02 14 24291626 24291921 296 - 1.271 0.921 -1.269
ENSG00000157379 E011 84.9552047 0.0047971532 3.074551e-01 4.496857e-01 14 24292184 24292211 28 - 1.805 1.866 0.205
ENSG00000157379 E012 158.2499371 0.0002969146 6.954928e-02 1.426180e-01 14 24292212 24292330 119 - 2.069 2.133 0.215
ENSG00000157379 E013 16.1769511 0.0011369004 2.508616e-09 3.454352e-08 14 24292331 24292620 290 - 1.488 0.993 -1.752
ENSG00000157379 E014 6.5093432 0.0025957496 1.129272e-05 7.412158e-05 14 24292621 24292651 31 - 1.153 0.630 -2.019
ENSG00000157379 E015 109.9576903 0.0003087605 4.588519e-01 5.991023e-01 14 24292652 24292701 50 - 1.939 1.973 0.113
ENSG00000157379 E016 128.6814458 0.0002502959 1.412803e-01 2.498005e-01 14 24292702 24292784 83 - 1.986 2.044 0.194
ENSG00000157379 E017 22.3741596 0.0008511401 1.206962e-23 1.150178e-21 14 24292785 24294656 1872 - 1.718 1.001 -2.505
ENSG00000157379 E018 135.7631710 0.0002466047 3.886721e-01 5.327524e-01 14 24296509 24296588 80 - 2.029 2.063 0.116
ENSG00000157379 E019 0.3030308 0.3878423060 8.042903e-02   14 24296662 24296737 76 - 0.324 0.000 -14.241
ENSG00000157379 E020 178.7976036 0.0002647386 6.477789e-01 7.594079e-01 14 24296738 24296881 144 - 2.180 2.171 -0.030
ENSG00000157379 E021 0.3030308 0.3878423060 8.042903e-02   14 24298711 24298956 246 - 0.324 0.000 -14.241
ENSG00000157379 E022 183.6163195 0.0002404909 2.354405e-01 3.688861e-01 14 24298957 24299130 174 - 2.208 2.178 -0.100
ENSG00000157379 E023 0.1515154 0.0431688286 1.618893e-01   14 24299216 24299580 365 - 0.191 0.000 -14.614
ENSG00000157379 E024 141.6705179 0.0002747907 2.080232e-02 5.317470e-02 14 24299581 24299780 200 - 2.127 2.056 -0.238