ENSG00000157353

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288078 ENSG00000157353 HEK293_OSMI2_2hA HEK293_TMG_2hB FCSK protein_coding protein_coding 9.105745 11.18739 5.764996 0.599595 0.4474687 -0.9552705 2.3290501 5.1218003 1.3321366 0.64946705 0.2377150 -1.9349335 0.25012500 0.45730000 0.23296667 -0.22433333 0.03593790 0.02839489 FALSE TRUE
ENST00000485034 ENSG00000157353 HEK293_OSMI2_2hA HEK293_TMG_2hB FCSK protein_coding retained_intron 9.105745 11.18739 5.764996 0.599595 0.4474687 -0.9552705 1.6449136 1.6058003 0.9259795 0.11873011 0.1555785 -0.7877001 0.17937500 0.14320000 0.16243333 0.01923333 0.88660392 0.02839489 TRUE FALSE
ENST00000498702 ENSG00000157353 HEK293_OSMI2_2hA HEK293_TMG_2hB FCSK protein_coding nonsense_mediated_decay 9.105745 11.18739 5.764996 0.599595 0.4474687 -0.9552705 0.8165737 1.3974029 0.6068946 0.57350994 0.2952011 -1.1899394 0.08269583 0.12350000 0.10430000 -0.01920000 0.92466858 0.02839489 FALSE TRUE
ENST00000571487 ENSG00000157353 HEK293_OSMI2_2hA HEK293_TMG_2hB FCSK protein_coding retained_intron 9.105745 11.18739 5.764996 0.599595 0.4474687 -0.9552705 0.8192870 0.6978060 0.6069476 0.07319145 0.1460531 -0.1982060 0.09522500 0.06220000 0.10286667 0.04066667 0.27149304 0.02839489 TRUE TRUE
ENST00000573832 ENSG00000157353 HEK293_OSMI2_2hA HEK293_TMG_2hB FCSK protein_coding retained_intron 9.105745 11.18739 5.764996 0.599595 0.4474687 -0.9552705 0.7365708 0.1722087 0.7153856 0.11041804 0.2092344 1.9931565 0.08000000 0.01473333 0.11993333 0.10520000 0.02839489 0.02839489 FALSE TRUE
MSTRG.12931.1 ENSG00000157353 HEK293_OSMI2_2hA HEK293_TMG_2hB FCSK protein_coding   9.105745 11.18739 5.764996 0.599595 0.4474687 -0.9552705 0.5971796 0.8662505 0.2132704 0.10468201 0.2132704 -1.9725516 0.05630000 0.07740000 0.04283333 -0.03456667 0.31689311 0.02839489 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000157353 E001 0.9567719 0.0629260915 5.015632e-02 1.094381e-01 16 70454566 70454580 15 + 0.503 0.142 -2.493
ENSG00000157353 E002 0.9933036 0.0132956264 2.184769e-01 3.485749e-01 16 70454581 70454594 14 + 0.421 0.199 -1.495
ENSG00000157353 E003 1.1448190 0.0121940421 8.756507e-02 1.714424e-01 16 70454595 70454602 8 + 0.503 0.199 -1.910
ENSG00000157353 E004 13.0820469 0.0245310117 8.451405e-03 2.491392e-02 16 70454603 70454630 28 + 1.279 0.976 -1.089
ENSG00000157353 E005 0.6664265 0.0176958489 3.135409e-01 4.561546e-01 16 70454727 70454805 79 + 0.321 0.142 -1.495
ENSG00000157353 E006 0.9640450 0.0145841589 2.187233e-01 3.488770e-01 16 70454806 70454940 135 + 0.421 0.199 -1.496
ENSG00000157353 E007 0.2998086 0.0297152519 4.476677e-01   16 70457913 70457975 63 + 0.189 0.077 -1.498
ENSG00000157353 E008 0.0000000       16 70462173 70462292 120 +      
ENSG00000157353 E009 26.7927115 0.0145837670 5.249589e-02 1.136048e-01 16 70463169 70463272 104 + 1.484 1.316 -0.584
ENSG00000157353 E010 46.1576596 0.0005369707 6.407692e-02 1.334827e-01 16 70463623 70463774 152 + 1.671 1.567 -0.355
ENSG00000157353 E011 0.6696487 0.0287024547 4.515883e-02 1.004840e-01 16 70465030 70465125 96 + 0.422 0.077 -3.078
ENSG00000157353 E012 33.8011110 0.0009305682 4.062489e-01 5.499060e-01 16 70465126 70465176 51 + 1.507 1.452 -0.189
ENSG00000157353 E013 45.0013494 0.0004960130 2.401332e-01 3.742945e-01 16 70466132 70466257 126 + 1.634 1.567 -0.230
ENSG00000157353 E014 1.0361649 0.0134938490 6.982595e-01 7.982618e-01 16 70466258 70466544 287 + 0.321 0.249 -0.495
ENSG00000157353 E015 32.0126464 0.0006687087 1.882451e-01 3.115252e-01 16 70466882 70466954 73 + 1.507 1.418 -0.305
ENSG00000157353 E016 20.5580668 0.0065845929 2.711291e-01 4.098315e-01 16 70466955 70467373 419 + 1.327 1.229 -0.342
ENSG00000157353 E017 32.5368756 0.0006718050 9.759882e-01 9.890135e-01 16 70467374 70467471 98 + 1.444 1.446 0.010
ENSG00000157353 E018 14.1753600 0.0031157345 1.730308e-03 6.378176e-03 16 70467472 70467885 414 + 1.315 1.021 -1.050
ENSG00000157353 E019 30.1330280 0.0007258324 5.534015e-01 6.825715e-01 16 70467886 70467966 81 + 1.444 1.402 -0.143
ENSG00000157353 E020 43.9099284 0.0029308959 4.712882e-01 6.104213e-01 16 70468849 70468968 120 + 1.529 1.578 0.168
ENSG00000157353 E021 0.3332198 0.0284524394 4.489868e-01   16 70468969 70468974 6 + 0.189 0.077 -1.495
ENSG00000157353 E022 40.0195964 0.0014832334 6.586788e-02 1.364901e-01 16 70469152 70469323 172 + 1.426 1.554 0.437
ENSG00000157353 E023 34.6601038 0.0006531469 5.073930e-02 1.104862e-01 16 70470314 70470426 113 + 1.359 1.500 0.487
ENSG00000157353 E024 28.2938526 0.0059464575 5.765287e-02 1.225983e-01 16 70470971 70471072 102 + 1.254 1.420 0.580
ENSG00000157353 E025 17.0208321 0.0030657674 5.844843e-01 7.083922e-01 16 70471182 70471197 16 + 1.132 1.187 0.194
ENSG00000157353 E026 41.9540209 0.0008128765 8.452500e-01 9.037273e-01 16 70471198 70471352 155 + 1.543 1.555 0.044
ENSG00000157353 E027 0.6245948 0.0366879939 3.994872e-01 5.432335e-01 16 70472514 70472540 27 + 0.000 0.200 9.364
ENSG00000157353 E028 34.7043369 0.0006489547 2.967641e-01 4.380294e-01 16 70472541 70472605 65 + 1.529 1.461 -0.232
ENSG00000157353 E029 60.1079944 0.0004388247 2.218453e-02 5.605666e-02 16 70472983 70473353 371 + 1.790 1.677 -0.382
ENSG00000157353 E030 14.5539636 0.0043658374 4.833920e-01 6.213930e-01 16 70474129 70474134 6 + 1.166 1.096 -0.253
ENSG00000157353 E031 55.0858778 0.0202223168 8.757485e-01 9.242009e-01 16 70474135 70474339 205 + 1.681 1.670 -0.035
ENSG00000157353 E032 40.1814007 0.0007055337 3.603492e-03 1.202033e-02 16 70474528 70474624 97 + 1.369 1.571 0.695
ENSG00000157353 E033 22.6606839 0.0012385019 1.032156e-02 2.956037e-02 16 70474625 70474625 1 + 1.096 1.334 0.842
ENSG00000157353 E034 41.6439862 0.0005614345 2.259129e-02 5.690083e-02 16 70474626 70474694 69 + 1.426 1.578 0.521
ENSG00000157353 E035 3.6589195 0.0210256595 4.918122e-01 6.290625e-01 16 70474789 70474789 1 + 0.684 0.571 -0.491
ENSG00000157353 E036 53.4104421 0.0004609619 6.813563e-01 7.850634e-01 16 70474790 70475011 222 + 1.671 1.650 -0.073
ENSG00000157353 E037 28.3080516 0.0198670866 2.330710e-01 3.660637e-01 16 70475350 70475415 66 + 1.477 1.361 -0.400
ENSG00000157353 E038 25.2851168 0.1196806740 9.462169e-01 9.702396e-01 16 70475416 70475493 78 + 1.392 1.331 -0.210
ENSG00000157353 E039 43.2926906 0.0063163850 5.624287e-01 6.900220e-01 16 70475648 70475767 120 + 1.536 1.579 0.146
ENSG00000157353 E040 3.1323446 0.0051050905 4.059704e-03 1.330912e-02 16 70475768 70475853 86 + 0.846 0.407 -1.954
ENSG00000157353 E041 5.6571600 0.0034275000 7.403013e-06 5.066758e-05 16 70476187 70476334 148 + 1.115 0.547 -2.254
ENSG00000157353 E042 34.5762449 0.0054252894 2.547696e-03 8.905701e-03 16 70477358 70478271 914 + 1.623 1.411 -0.726
ENSG00000157353 E043 77.3512358 0.0020450030 2.627051e-02 6.449144e-02 16 70478272 70478459 188 + 1.724 1.840 0.395
ENSG00000157353 E044 68.8168674 0.0023478492 2.644604e-01 4.024323e-01 16 70478551 70478650 100 + 1.715 1.777 0.212
ENSG00000157353 E045 5.5530292 0.0030271070 8.851271e-01 9.305638e-01 16 70478651 70478796 146 + 0.772 0.752 -0.081
ENSG00000157353 E046 15.7697192 0.0011648556 8.730582e-01 9.224151e-01 16 70478797 70479179 383 + 1.166 1.152 -0.052
ENSG00000157353 E047 102.5637503 0.0017349592 7.996555e-02 1.595076e-01 16 70479180 70479403 224 + 1.877 1.956 0.265
ENSG00000157353 E048 205.9608839 0.0039551678 5.172095e-02 1.122200e-01 16 70479579 70480285 707 + 2.178 2.256 0.262